Devil's Claw: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Devil's claw (Harpagophytum procumbens) is an herb. It has been used by mouth for back pain and arthritis, but there is little evidence to support these uses.

Devil's claw is native to south Africa, including the Kalahari Desert, where it's been used traditionally for many conditions. Devil's claw contains chemicals that might decrease swelling. Because of this, it is often used to treat conditions that involve both pain and inflammation.

Devil's claw is most commonly used for back pain and osteoarthritis. It is also used for rheumatoid arthritis (RA) and other conditions, but there is no good scientific evidence to support these uses. There is also no good evidence to support using devil's claw for COVID-19.

Uses & Effectiveness

Possibly Effective for

Back pain. Taking devil's claw by mouth seems to reduce lower back pain. Devil's claw seems to work about as well as some non-steroidal anti-inflammatory drugs (NSAIDs).
Osteoarthritis. Taking devil's claw by mouth alone, with other ingredients, or along with nonsteroidal anti-inflammatory drugs (NSAIDs) seems to help reduce osteoarthritis pain. Some people taking devil's claw seem to be able to lower the dose of NSAIDs taken for pain relief.

There is interest in using devil's claw for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Devil's claw is possibly safe for most adults when taken for up 12 weeks. The most common side effects are diarrhea and indigestion. Devil's claw may also cause allergic skin reactions.

When applied to the skin: There isn't enough reliable information to know if devil's claw is safe or what the side effects might be.

Special Precautions and Warnings

Pregnancy: Devil's claw is possibly unsafe when used during pregnancy. It might harm the developing fetus. Avoid use.

Breast-feeding: There isn't enough reliable information to know if devil's claw is safe to use when breast-feeding. Stay on the safe side and avoid use.

Heart and circulation problems: Devil's claw may affect heart rate, heartbeat, and blood pressure. It might harm people with disorders of the heart and circulation. If you have one of these conditions, talk with your healthcare provider before starting devil's claw.

Gallstones: Devil's claw might increase bile production. This could be a problem for people with gallstones. Avoid using devil's claw.

Low levels of sodium in the body: Devil's claw might decrease levels of sodium in the body. This might worsen symptoms in people who already have low levels of sodium.

Peptic ulcer disease: Devil's claw might increase the production of stomach acids, which might harm people with stomach ulcers. Avoid using devil's claw.

Interactions

Moderate Interaction

Be cautious with this combination

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with Devil's Claw
Some medications are changed and broken down by the liver. Devil's claw might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Warfarin (Coumadin) interacts with Devil's Claw
Warfarin is used to slow blood clotting. Devil's claw might increase its effects and the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin might need to be changed.
Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates) interacts with Devil's Claw
Some medications are changed and broken down by the liver. Devil's claw might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with Devil's Claw
Some medications are changed and broken down by the liver. Devil's claw might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Minor Interaction

Be watchful with this combination

Medications moved by pumps in cells (P-glycoprotein Substrates) interacts with Devil's Claw
Some medications are moved in and out of cells by pumps. Devil's claw might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
Medications that decrease stomach acid (H2-blockers) interacts with Devil's Claw
H2-blockers are used to decrease stomach acid. Devil's claw can increase stomach acid. Taking Devil's claw might decrease the effects of H2-blockers.

Some common H2-blockers include cimetidine (Tagamet), ranitidine (Zantac), and famotidine (Pepcid).
Medications that decrease stomach acid (Proton pump inhibitors) interacts with Devil's Claw
Proton pump inhibitors are used to decrease stomach acid. Devil's claw can increase stomach acid. Taking devil's claw might decrease the effects of proton pump inhibitors.

Some common proton pump inhibitors include omeprazole (Prilosec), lansoprazole (Prevacid), rabeprazole (Aciphex), pantoprazole (Protonix), and esomeprazole (Nexium).

Dosing

Devil's claw has most often been used by adults in doses of 108-2400 mg daily for 8-12 weeks. Speak with a healthcare provider to find out what dose might be best for a specific condition.

View References

REFERENCES:

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Painkillers and Opioid Use Disorder

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Devil's Claw - Uses, Side Effects, and More

Overview

Uses & Effectiveness

Possibly Effective for

Side Effects

Special Precautions and Warnings

Interactions

Moderate Interaction

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with Devil's Claw

Warfarin (Coumadin) interacts with Devil's Claw

Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates) interacts with Devil's Claw

Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with Devil's Claw

Minor Interaction

Medications moved by pumps in cells (P-glycoprotein Substrates) interacts with Devil's Claw

Medications that decrease stomach acid (H2-blockers) interacts with Devil's Claw

Medications that decrease stomach acid (Proton pump inhibitors) interacts with Devil's Claw

Dosing

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