Calabrese C, Myer S, Munson S, et al. A cross-over study of the effect of a single oral feeding of medium chain triglyceride oil vs canola oil on post-ingestion plasma triglyceride levels in healthy men. Altern Med Rev 1999;4:23-8.
Sills MA, Forsythe WI, Haidukewych D, et al. The medium chain triglyceride diet and intractable epilepsy. Arch Dis Child 1986;61:1168-72.
Trauner DA. Medium-chain triglyceride (MCT) diet in intractable seizure disorders. Neurology 1985;35:237-8.
Nijveldt RJ, Tan AM, Prins HA, et al. Use of a mixture of medium-chain triglycerides and longchain triglycerides versus long-chain triglycerides in critically ill surgical patients: a randomized prospective double-blind study. Clin Nutr 1998;17:23-9.
Ball MJ. Parenteral nutrition in the critically ill: use of a medium chain triglyceride emulsion. Intensive Care Med 1993;19:89-95.
Clarke PJ, Ball MJ, Hands LJ, et al. Use of a lipid containing medium chain triglycerides in patients receiving TPN: a randomized prospective trial. Br J Surg 1987;74:701-4.
St-Onge MP, Jones PJ. Physiological effects of medium-chain triglycerides: potential agents in the prevention of obesity. J Nutr 2002;132:329-32..
Ruppin DC, Middleton WR. Clinical use of medium chain triglycerides. Drugs 1980;20:216-24.
Bach AC, Babayan VK. Medium-chain triglycerides: an update. Am J Clin Nutr 1982;36:950-62.
Babayan VK. Medium chain triglycerides and structured lipids. Lipids 1987;22:417-20.
Christophe A, Matthys F, Verdonk G. Chylous-fluid triglycerides and lipoproteins in a patient with chylothorax put on a diet of butter or medium-chain triglyceride [proceeedings]. Arch Int Physiol Biochim 1980;88:B17-B19.
Jalili F. Medium-chain triglycerides and total parenteral nutrition in the management of infants with congenital chylothorax. South Med J 1987;80:1290-3..
Jensen GL, Mascioli EA, Meyer LP, et al. Dietary modification of chyle composition in chylothorax. Gastroenterology 1989;97:761-5.
Fernandez Alvarez JR, Kalache KD, Grauel EL. Management of spontaneous congenital chylothorax: oral medium-chain triglycerides versus total parenteral nutrition. Am J Perinatol 1999;16:415-20.
Gibert CL, Wheeler DA, Collins G, et al. Randomized, controlled trial of caloric supplements in HIV infection. J Acquir Immune Defic Syndr 1999;22:253-9.
Henderson ST, Vogel JL, Barr LJ, et al. Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial. Nutr Metab (Lond) 2009;6:31.
Reger MA, Henderson ST, Hale C, et al. Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging 2004;25:311-4.
Abe S, Ezaki O, Suzuki M. Medium-Chain Triglycerides in Combination with Leucine and Vitamin D Increase Muscle Strength and Function in Frail Elderly Adults in a Randomized Controlled Trial. J Nutr. 2016 May;146(5):1017-26.
Bhavsar N, St-Onge MP. The diverse nature of saturated fats and the case of medium-chain triglycerides: how one recommendation may not fit all. Curr Opin Clin Nutr Metab Care. 2016 Mar;19(2):81-7.
Clegg ME. Medium-chain triglycerides are advantageous in promoting weight loss although not beneficial to exercise performance. Int J Food Sci Nutr. 2010 Nov;61(7):653-79.
Coleman H, Quinn P, Clegg ME. Medium-chain triglycerides and conjugated linoleic acids in beverage form increase satiety and reduce food intake in humans. Nutr Res. 2016 Jun;36(6):526-33.
Desai AP, Guvenc BH, Carachi R. Evidence for medium chain triglycerides in the treatment of primary intestinal lymphangiectasia. Eur J Pediatr Surg. 2009 Aug;19(4):241-5.
McCarty MF, DiNicolantonio JJ. Lauric acid-rich medium-chain triglycerides can substitute for other oils in cooking applications and may have limited pathogenicity. Open Heart. 2016 Jul 27;3(2):e000467.
Mumme K, Stonehouse W. Effects of medium-chain triglycerides on weight loss and body composition: a meta-analysis of randomized controlled trials. J Acad Nutr Diet. 2015 Feb;115(2):249-63.
Rego Costa AC, Rosado EL, Soares-Mota M. Influence of the dietary intake of medium chain triglycerides on body composition, energy expenditure and satiety: a systematic review. Nutr Hosp. 2012 Jan-Feb;27(1):103-8.
Brighenti F. Dietary fructans and serum triacylglycerols: a meta-analysis of randomized controlled trials. J Nutr. 2007 Nov;137(11 Suppl):2552S-2556S. doi: 10.1093/jn/137.11.2552S.
St-Onge MP, Mayrsohn B, O'Keeffe M, Kissileff HR, Choudhury AR, Laferrère B. Impact of medium and long chain triglycerides consumption on appetite and food intake in overweight men. Eur J Clin Nutr. 2014 Oct;68(10):1134-40.
Szefel J, Kruszewski WJ, Szajewski M, Ciesielski M, Sobczak E, Czerepko M, Lysiak-Szydlowska W. Medium-chain triglycerides/long-chain triglycerides versus long-chain triglycerides in treatment of cancer patients with major body mass loss. Survival in patients with refractory cachexia. Prz Gastroenterol. 2016;11(3):181-186.
Xue C, Liu Y, Wang J, Zhang R, Zhang Y, Zhang J, Zhang Y, Zheng Z, Yu X, Jing H, Nosaka N, Arai C, Kasai M, Aoyama T, Wu J. Consumption of medium- and long-chain triacylglycerols decreases body fat and blood triglyceride in Chinese hypertriglyceridemic subjects. Eur J Clin Nutr. 2009 Jul;63(7):879-86.
Zhang Y, Liu Y, Wang J, Zhang R, Jing H, Yu X, Zhang Y, Xu Q, Zhang J, Zheng Z, Nosaka N, Arai C, Kasai M, Aoyama T, Wu J, Xue C. Medium- and long-chain triacylglycerols reduce body fat and blood triacylglycerols in hypertriacylglycerolemic, overweight but not obese, Chinese individuals. Lipids. 2010 Jun;45(6):501-10.
Jain A, Mochi TB, Braganza SD, Agrawal S, Shetty BK, Pachiyappan B. Lipemia retinalis in an infant treated for retinopathy of prematurity. J AAPOS 2017;21(3):254-57.
Augustin K, Khabbush A, Williams S, et al. Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders. Lancet Neurol. 2018;17(1):84-93.
Sampaio LP. Ketogenic diet for epilepsy treatment. Arq Neuropsiquiatr. 2016;74(10):842-848.
Kossoff EH, Zupec-Kania BA, Auvin S, et al. Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group. Epilepsia Open. 2018;3(2):175-192.
Maher T, Sampson A, Goslawska M, Pangua-Irigaray C, Shafat A, Clegg ME. Food intake and satiety response after medium-chain triglycerides ingested as solid or liquid. Nutrients. 2019;11(7):1638.
Borges K, Kaul N, Germaine J, Kwan P, O'Brien TJ. Randomized trial of add-on triheptanoin vs medium chain triglycerides in adults with refractory epilepsy. Epilepsia Open. 2019;4(1):153-163.
Arsenault AB, Gunsalus KTW, Laforce-Nesbitt SS, et al. Dietary supplementation with medium-chain triglycerides reduces candida gastrointestinal colonization in preterm infants. Pediatr Infect Dis J. 2019;38(2):164-168.
Abe S, Ezaki O, Suzuki M. Medium-chain triglycerides (8:0 and 10:0) are promising nutrients for sarcopenia: a randomized controlled trial. Am J Clin Nutr. 2019;110(3):652-665.
Avgerinos KI, Egan JM, Mattson MP, Kapogiannis D. Medium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer's disease. A systematic review and meta-analysis of human studies. Ageing Res Rev. 2020;58:101001.
Fortier M, Castellano CA, Croteau E, et al. A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment. Alzheimers Dement. 2019;15(5):625-634.
Maher T, Deleuse M, Thondre S, Shafat A, Clegg ME. A comparison of the satiating properties of medium-chain triglycerides and conjugated linoleic acid in participants with healthy weight and overweight or obesity. Eur J Nutr 2021;60(1):203-215.
Abe S, Ezaki O, Suzuki M. Medium-Chain Triglycerides (8:0 and 10:0) Increase Mini-Mental State Examination (MMSE) Score in Frail Elderly Adults in a Randomized Controlled Trial. J Nutr 2020;150(9):2383-2390.
Perretta L, Ouldibbat L, Hagadorn JI, Brumberg HL. High versus low medium chain triglyceride content of formula for promoting short-term growth of preterm infants. Cochrane Database Syst Rev 2021;2(2):CD002777.
McKenzie KM, Lee CM, Mijatovic J, Haghighi MM, Skilton MR. Medium-Chain Triglyceride Oil and Blood Lipids: A Systematic Review and Meta-Analysis of Randomized Trials. J Nutr 2021;151(10):2949-2956.
Myette-Côté É, St-Pierre V, Beaulieu S, et al. The effect of a 6-month ketogenic medium-chain triglyceride supplement on plasma cardiometabolic and inflammatory markers in mild cognitive impairment. Prostaglandins Leukot Essent Fatty Acids 2021;169:102236.
Roy M, Fortier M, Rheault F, et al. A ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment. Alzheimers Dement (N Y) 2021;7(1):e12217.
Baumeister A, Gardemann J, Fobker M, Spiegler V, Fischer T. Short-Term Influence of Caffeine and Medium-Chain Triglycerides on Ketogenesis: A Controlled Double-Blind Intervention Study. J Nutr Metab 2021;2021:1861567.
Harvey CJ d C, Schofield GM, Williden M, McQuillan JA. The Effect of Medium Chain Triglycerides on Time to Nutritional Ketosis and Symptoms of Keto-Induction in Healthy Adults: A Randomised Controlled Clinical Trial. J Nutr Metab 2018;2018:2630565.
Prins PJ, Koutnik AP, D'Agostino DP, et al. Effects of an Exogenous Ketone Supplement on Five-Kilometer Running Performance. J Hum Kinet 2020;72:115-127.
Liao YC, Wan YH, Chen PH, Hsieh LY. Efficacy of medium-chain triglyceride oil massage on growth in preterm infants: a randomized controlled trial: A CONSORT-compliant article. Medicine (Baltimore) 2021;100(30):e26794.
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