McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
Gossel TA, Bricker JD. Principles of Clinical Toxicology. New York, NY:Raven Press, 1994.
Hardman JG, Limbird LL, Molinoff PB, eds. Goodman and Gillman's The Pharmacological Basis of Therapeutics, 9th ed. New York, NY: McGraw-Hill, 1996.
Clarkson PM, Haymes EM. Trace mineral requirements for athletes. Int J Sport Nutr 1994;4:104-19.
Clarkson PM. Minerals: exercise performance and supplementation in athletes. J Sports Sci 1991;9:91-116.
Campbell WW, Anderson RA. Effects of aerobic exercise and training on the trace minerals chromium, zinc and copper. Sports Med 1987 4:9-18.
Broun ER, Greist A, Tricot G, Hoffman R. Excessive zinc ingestion. A reversible cause of sideroblastic anemia and bone marrow depression. JAMA 1990;264:1441-3.
Sandstead HH. Requirements and toxicity of essential trace elements, illustrated by zinc and copper. Am J Clin Nutr 1995;61:621S-4S.
Brewer GJ, Dick RD, Johnson VD, et al. Treatment of Wilson's disease with zinc: XV long-term follow-up studies. J Lab Clin Med 1998;132:264-78.
Weight LM, Noakes TD, Labadarios D, et al. Vitamin and mineral status of trained athletes including the effects of supplementation. Am J Clin Nutr 1988;47:186-91.
Finley EB, Cerklewski FL. Influence of ascorbic acid supplementation on copper status in young adult men. Am J Clin Nutr 1983;37:553-6.
Strause L, Saltman P, Smith KT, et al. Spinal bone loss in postmenopausal women supplemented with calcium and trace minerals. J Nutr 1994;124:1060-4.
Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
Campbell IA, Elmes PC. Ethambutol and the eye: zinc and copper (letter). Lancet 1975;2:711.
Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
Kozak SF, Inderlied CB, Hsu HY, et al. The role of copper on ethambutol's antimicrobial action and implications for ethambutol-induced optic neuropathy. Diag Microbiol Infect Dis 1998;30:83-7.
Baum MK, Javier JJ, Mantero-Atienza E, et al. Zidovudine-associated adverse reactions in a longitudinal study of asymptomatic HIV-1-infected homosexual males. J Acquir Immune Defic Syndr 1991;4:1218-26.
Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002. Available at: www.nap.edu/books/0309072794/html/.
Rubin MA, Miller JP, Ryan AS, et al. Acute and chronic resistive exercise increase urinary chromium excretion in men as measured with an enriched chromium stable isotope. J Nutr 1998;128:73-78.
Lai H, Lai S, Shor-Posner G, et al. Plasma zinc, copper, copper:zinc ratio, and survival in a cohort of HIV-1-infected homosexual men. J Acquir Immune Defic Syndr Human Retrovirol 2001;27:56-62.
Cole A, May PM, Williams DR. Metal binding by pharmaceuticals. Part 1. Copper(II) and zinc(II) interactions following ethambutol administration. Agents Actions 1981;11:296-305.
Cantilena LR, Klaassen CD. The effect of chelating agents on the excretion of endogenous metals. Toxicol Appl Pharmacol 1982;63:344-50.
Nechifor M, Vaideanu C, Palamaru I, et al. The influence of some antipsychotics on erythrocyte magnesium and plasma magnesium, calcium, copper and zinc in patients with paranoid schizophrenia. J Am Coll Nutr 2004;23:549S-51S.
Duffy EM, Meenagh GK, McMillan SA, et al. The clinical effect of dietary supplementation with omega-3 fish oils and/or copper in systemic lupus erythematosus. J Rheumatol 2004;31:1551-6.
Castillo-Duran, C., Vial, P., and Uauy, R. Oral copper supplementation: effect on copper and zinc balance during acute gastroenteritis in infants. Am.J.Clin.Nutr. 1990;51(6):1088-1092. 2349923.
Salim, S, Farquharson, J, Arneil, G, et al. Dietary copper intake in artificially fed infants. Arch Dis.Child 1986;61(11):1068-1075. 3789787.
Valberg, LS, Flanagan, PR, Chamberlain, MJ. Effects of iron, tin, and copper on zinc absorption in humans. Am J Clin Nutr 1984;40(3):536-541.
Rhee, Y. S., Hermann, J. R., Burnham, K., Arquitt, A. B., and Stoecker, B. J. The effects of chromium and copper supplementation on mitogen-stimulated T cell proliferation in hypercholesterolaemic postmenopausal women. Clin.Exp.Immunol. 2002;127(3):463-469.
Rahman, B., Rahman, M. A., and Hassan, Z. Copper and caeruloplasmin in schizophrenia. Biochem Soc Trans 1976;4(6):1138-1139.
Baker, A., Harvey, L., Majask-Newman, G., Fairweather-Tait, S., Flynn, A., and Cashman, K. Effect of dietary copper intakes on biochemical markers of bone metabolism in healthy adult males. Eur.J.Clin.Nutr. 1999;53(5):408-412.
O'Donohue, J., Reid, M., Varghese, A., Portmann, B., and Williams, R. A case of adult chronic copper self-intoxication resulting in cirrhosis. Eur J Med Res 6-28-1999;4(6):252.
Baker, A., Turley, E., Bonham, M. P., O'Connor, J. M., Strain, J. J., Flynn, A., and Cashman, K. D. No effect of copper supplementation on biochemical markers of bone metabolism in healthy adults. Br.J.Nutr. 1999;82(4):283-290.
Sheth, S. and Brittenham, G. M. Genetic disorders affecting proteins of iron metabolism: clinical implications. Annu Rev Med 2000;51:443-464.
Herran, A., Garcia-Unzueta, M. T., Fernandez-Gonzalez, M. D., Vazquez-Barquero, J. L., Alvarez, C., and Amado, J. A. Higher levels of serum copper in schizophrenic patients treated with depot neuroleptics. Psychiatry Res 4-24-2000;94(1):51-58.
Porea, T. J., Belmont, J. W., and Mahoney, D. H., Jr. Zinc-induced anemia and neutropenia in an adolescent. J Pediatr 2000;136(5):688-690.
George, D. H. and Casey, R. E. Menkes disease after copper histidine replacement therapy: case report. Pediatr Dev.Pathol. 2001;4(3):281-288.
Kumar, A. and Jazieh, A. R. Case report of sideroblastic anemia caused by ingestion of coins. Am J Hematol. 2001;66(2):126-129.
Cashman, K. D., Baker, A., Ginty, F., Flynn, A., Strain, J. J., Bonham, M. P., O'Connor, J. M., Bugel, S., and Sandstrom, B. No effect of copper supplementation on biochemical markers of bone metabolism in healthy young adult females despite apparently improved copper status. Eur.J.Clin.Nutr. 2001;55(7):525-531.
Araya, M., McGoldrick, M. C., Klevay, L. M., Strain, J. J., Robson, P., Nielsen, F., Olivares, M., Pizarro, F., Johnson, L. A., and Poirier, K. A. Determination of an acute no-observed-adverse-effect level (NOAEL) for copper in water. Regul.Toxicol.Pharmacol. 2001;34(2):137-145.
Olatunbosun, D. A., Akindele, M. O., Adadevoh, B. K., and Asuni, T. Serum copper in schizophrenia in Nigerians. Br J Psychiatry 1975;127:119-121.
Kirodian, B. G., Gogtay, N. J., Udani, V. P., and Kshirsagar, N. A. Treatment of Menkes disease with parenteral copper histidine. Indian Pediatr 2002;39(2):183-185.
Kimura, A., Yoshino, H., and Yuasa, T. [A case of cerebellar degeneration with schizophrenia-like psychosis, severe iron deficiency, hypoceruloplasminemia and abnormal electroretinography: a new syndrome?]. Rinsho Shinkeigaku 2001;41(8):507-511.
Gregg, X. T., Reddy, V., and Prchal, J. T. Copper deficiency masquerading as myelodysplastic syndrome. Blood 8-15-2002;100(4):1493-1495.
Bonham, M., O'Connor, J. M., McAnena, L. B., Walsh, P. M., Downes, C. S., Hannigan, B. M., and Strain, J. J. Zinc supplementation has no effect on lipoprotein metabolism, hemostasis, and putative indices of copper status in healthy men. Biol.Trace Elem.Res. 2003;93(1-3):75-86.
Harvey, L. J., Majsak-Newman, G., Dainty, J. R., Lewis, D. J., Langford, N. J., Crews, H. M., and Fairweather-Tait, S. J. Adaptive responses in men fed low- and high-copper diets. Br J Nutr 2003;90(1):161-168.
Irving, J. A., Mattman, A., Lockitch, G., Farrell, K., and Wadsworth, L. D. Element of caution: a case of reversible cytopenias associated with excessive zinc supplementation. CMAJ. 7-22-2003;169(2):129-131.
Tokdemir, M., Polat, S. A., Acik, Y., Gursu, F., Cikim, G., and Deniz, O. Blood zinc and copper concentrations in criminal and noncriminal schizophrenic men. Arch Androl 2003;49(5):365-368.
Czeizel, A. E. and Dudas, I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl.J Med 12-24-1992;327(26):1832-1835.
DOGAN, S., KELER, M., and PERSIC, N. [Copper in blood in schizophrenia; a problem of pathophysiology of schizophrenia.]. Acta Med Iugosl. 1955;9(1):60-70.
OZEK, M. [Research on copper metabolism in several forms of schizophrenia.]. Arch Psychiatr.Nervenkr.Z Gesamte Neurol.Psychiatr. 1957;195(4):408-423.
BAKWIN, R. M., MOSBACH, E. H., and BAKWIN, H. Concentration of copper in serum of children with schizophrenia. Pediatrics 1961;27:642-644.
BAKWIN, R. M. Ceruloplasmin activity and copper levels in the serum of children with schizophrenia. J Am Med Womens Assoc 1961;16:522-523.
KOEGLER, R. R., COLBERT, E. G., and EIDUSON, S. Wanted: a biochemical test for schizophrenia. Calif.Med 1961;94:26-29.
KOLAKOWSKA, T., SZAJBEL, W., and MURAWSKI, K. [Serum ceruloplasmin and copper in schizophrenia.]. Neurol.Neurochir.Psychiatr.Pol. 1960;10:691-696.
MAAS, J. W., GLESER, G. C., and GOTTSCHALK, L. A. Schizophrenia, anxiety, and biochemical factors. The rate of oxidation of N, N-dimethyl-p-phenylenediamine by plasma and levels of serum copper and plasma ascorbic acid. Arch Gen.Psychiatry 1961;4:109-118.
MUNCH-PETERSEN, S. On serum copper in patients with schizophrenia. Acta Psychiatr.Neurol. 1951;25(4):423-427.
Yamazaki, H., Fujieda, M., Togashi, M., Saito, T., Preti, G., Cashman, J. R., and Kamataki, T. Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients. Life Sci. 4-16-2004;74(22):2739-2747.
Yanik, M., Kocyigit, A., Tutkun, H., Vural, H., and Herken, H. Plasma manganese, selenium, zinc, copper, and iron concentrations in patients with schizophrenia. Biol Trace Elem.Res 2004;98(2):109-117.
Araya, M., Olivares, M., Pizarro, F., Llanos, A., Figueroa, G., and Uauy, R. Community-based randomized double-blind study of gastrointestinal effects and copper exposure in drinking water. Environ.Health Perspect. 2004;112(10):1068-1073.
Gorter, R. W., Butorac, M., and Cobian, E. P. Examination of the cutaneous absorption of copper after the use of copper-containing ointments. Am J Ther 2004;11(6):453-458.
Willis, M. S., Monaghan, S. A., Miller, M. L., McKenna, R. W., Perkins, W. D., Levinson, B. S., Bhushan, V., and Kroft, S. H. Zinc-induced copper deficiency: a report of three cases initially recognized on bone marrow examination. Am J Clin Pathol 2005;123(1):125-131.
Turnlund, J. R., Keyes, W. R., Kim, S. K., and Domek, J. M. Long-term high copper intake: effects on copper absorption, retention, and homeostasis in men. Am J Clin Nutr 2005;81(4):822-828.
Munakata, M., Sakamoto, O., Kitamura, T., Ishitobi, M., Yokoyama, H., Haginoya, K., Togashi, N., Tamura, H., Higano, S., Takahashi, S., Ohura, T., Kobayashi, Y., Onuma, A., and Iinuma, K. The effects of copper-histidine therapy on brain metabolism in a patient with Menkes disease: a proton magnetic resonance spectroscopic study. Brain Dev. 2005;27(4):297-300.
Sheela, S. R., Latha, M., Liu, P., Lem, K., and Kaler, S. G. Copper-replacement treatment for symptomatic Menkes disease: ethical considerations. Clin Genet. 2005;68(3):278-283.
Bugel, S., Harper, A., Rock, E., O'Connor, J. M., Bonham, M. P., and Strain, J. J. Effect of copper supplementation on indices of copper status and certain CVD risk markers in young healthy women. Br.J Nutr 2005;94(2):231-236.
Wolf, T. L., Kotun, J., and Meador-Woodruff, J. H. Plasma copper, iron, ceruloplasmin and ferroxidase activity in schizophrenia. Schizophr.Res 2006;86(1-3):167-171.
Miller, T. R., Wagner, J. D., Baack, B. R., and Eisbach, K. J. Effects of topical copper tripeptide complex on CO2 laser-resurfaced skin. Arch Facial.Plast.Surg 2006;8(4):252-259.
Abdullah, A. Z., Strafford, S. M., Brookes, S. J., and Duggal, M. S. The effect of copper on demineralization of dental enamel. J Dent Res 2006;85(11):1011-1015.
Henry, N. L., Dunn, R., Merjaver, S., Pan, Q., Pienta, K. J., Brewer, G., and Smith, D. C. Phase II trial of copper depletion with tetrathiomolybdate as an antiangiogenesis strategy in patients with hormone-refractory prostate cancer. Oncology 2006;71(3-4):168-175.
Weis, S., Haybaeck, J., Dulay, J. R., and Llenos, I. C. Expression of cellular prion protein (PrP(c)) in schizophrenia, bipolar disorder, and depression. J Neural Transm. 2008;115(5):761-771.
Kessler, H., Bayer, T. A., Bach, D., Schneider-Axmann, T., Supprian, T., Herrmann, W., Haber, M., Multhaup, G., Falkai, P., and Pajonk, F. G. Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial. J Neural Transm. 2008;115(8):1181-1187.
Sorenson, J. R. Evaluation of copper complexes as potential anti-arthritic drugs. J Pharm Pharmacol 1977;29(7):450-452.
Tashiro, A., Satodate, R., and Segawa, I. Histological changes in cardiac hemochromatosis improved by an iron-chelating agent. A biopsy case. Acta Pathol Jpn. 1990;40(4):288-292.
Jendryczko, A., Drozdz, M., and Magner, K. Antilupus activity of copper (II). Exp Pathol. 1985;28(3):187-189.
August, D., Janghorbani, M., and Young, V. R. Determination of zinc and copper absorption at three dietary Zn-Cu ratios by using stable isotope methods in young adult and elderly subjects. Am J Clin Nutr 1989;50(6):1457-1463.
Strain, J. J. A reassessment of diet and osteoporosis--possible role for copper. Med Hypotheses 1988;27(4):333-338.
Simon, S. R., Branda, R. F., Tindle, B. F., and Burns, S. L. Copper deficiency and sideroblastic anemia associated with zinc ingestion. Am J Hematol. 1988;28(3):181-183.
Skalski, M. [Disorders of copper metabolism]. Wiad.Lek. 8-15-1986;39(16):1120-1123.
Patterson, W. P., Winkelmann, M., and Perry, M. C. Zinc-induced copper deficiency: megamineral sideroblastic anemia. Ann Intern Med 1985;103(3):385-386.
Silverstone, B. Z., Landau, L., Berson, D., and Sternbuch, J. Zinc and copper metabolism in patients with senile macular degeneration. Ann.Ophthalmol. 1985;17(7):419-422.
Tyrer, S. P., Delves, H. T., and Weller, M. P. CSF copper in schizophrenia. Am J Psychiatry 1979;136(7):937-939.
Ashkenazi, A., Levin, S., Djaldetti, M., Fishel, E., and Benvenisti, D. The syndrome of neonatal copper deficiency. Pediatrics 1973;52(4):525-533.
Chugh, T. D., Dhingra, R. K., Gulati, R. C., and Bathla, J. C. Copper metabolism in schizophrenia. Indian J Med Res 1973;61(8):1147-1152.
Puzynski, S. [Studies of the significance of disturbances in the metabolism of copper, ceruloplasmin and ascorbic acid in the pathogenesis of schizophrenia]. Rocz.Akad.Med Im Juliana Marchlewskiego Bialymst. 1969;14:99-162.
Chitre, V. S. and Punekar, B. D. Changes in serum copper and PPD-oxidase in different diseases. II. Comparative studies in Wilson's disease schizophrenia and Parkinsonism. Indian J Med Res 1970;58(5):563-573.
Burdeinyi, A. F. [Levels of copper and zinc in the blood of patients with various types of schizophrenia]. Zh.Nevropatol.Psikhiatr.Im S.S.Korsakova 1967;67(7):1041-1043.
da Silveira, S. V., Canato, C., de Jorge, F. B., and Delascio, D. [Copper, iron, magnesium and sulfur in the serum of pregnant women with sideroblastic anemia before, during, and after parenteral iron infusion therapy]. Matern.Infanc.(Sao Paulo) 1967;26(3):269-273.
Rivera Bandres J. [On some recently well-known anemias]. Rev Esp.Enferm.Apar.Dig 1966;25(8):942-958.
Shore, D., Potkin, S. G., Weinberger, D. R., Torrey, E. F., Henkin, R. I., Agarwal, R. P., Gillin, J. C., and Wyatt, R. J. CSF copper concentrations in chronic schizophrenia. Am J Psychiatry 1983;140(6):754-757.
Lei, K. Y. Oxidation, excretion, and tissue distribution of [26-14C] cholesterol in copper-deficient rats. J.Nutr. 1978;108(2):232-237.
Freycon, F. and Pouyau, G. [Rare nutritional deficiency anemia: deficiency of copper and vitamin E]. Sem.Hop. 2-17-1983;59(7):488-493.
Castillo-Duran, C., Fisberg, M., Valenzuela, A., Egana, J. I., and Uauy, R. Controlled trial of copper supplementation during the recovery from marasmus. Am.J.Clin.Nutr. 1983;37(6):898-903.
Kappel, L. C., Ingraham, R. H., Morgan, E. B., and Babcock, D. K. Plasma copper concentration and packed cell volume and their relationships to fertility and milk production in Holstein cows. Am.J.Vet.Res. 1984;45(2):346-350.
Humphries, W. R., Phillippo, M., Young, B. W., and Bremner, I. The influence of dietary iron and molybdenum on copper metabolism in calves. Br.J.Nutr. 1983;49(1):77-86.
Klevay, L. M. Interactions of copper and zinc in cardiovascular disease. Ann.N.Y.Acad.Sci. 1980;355:140-151.
Waler, S. M. and Rolla, G. Comparison between plaque inhibiting effect of chlorhexidine and aqueous solutions of copper- and silver-ions. Scand J Dent.Res 1982;90(2):131-133.
Klevay, L. M. The influence of copper and zinc on the occurrence of ischemic heart disease. J.Environ.Pathol.Toxicol. 1980;4(2-3):281-287.
Bowman, M. B. and Lewis, M. S. The copper hypothesis of schizophrenia: a review. Neurosci.Biobehav.Rev 1982;6(3):321-328.
Gillin, J. C., Carpenter, W. T., Hambidge, K. M., Wyatt, R. J., and Henkin, R. I. Zinc and copper in patients with schizophrenia. Encephale 1982;8(3):435-444.
Klevay, L. M., Reck, S. J., Jacob, R. A., Logan, G. M., Jr., Munoz, J. M., and Sandstead, H. H. The human requirement for copper. I. Healthy men fed conventional, American diets. Am.J.Clin.Nutr. 1980;33(1):45-50.
Kelley, D. S., Daudu, P. A., Taylor, P. C., Mackey, B. E., and Turnlund, J. R. Effects of low-copper diets on human immune response. Am.J.Clin.Nutr. 1995;62(2):412-416.
May, A. and Fitzsimons, E. Sideroblastic anaemia. Baillieres Clin Haematol. 1994;7(4):851-879.
Fiske, D. N., McCoy, H. E., III, and Kitchens, C. S. Zinc-induced sideroblastic anemia: report of a case, review of the literature, and description of the hematologic syndrome. Am J Hematol. 1994;46(2):147-150.
Kreuder, J., Otten, A., Fuder, H., Tumer, Z., Tonnesen, T., Horn, N., and Dralle, D. Clinical and biochemical consequences of copper-histidine therapy in Menkes disease. Eur J Pediatr 1993;152(10):828-832.
Sarkar, B., Lingertat-Walsh, K., and Clarke, J. T. Copper-histidine therapy for Menkes disease. J Pediatr 1993;123(5):828-830.
Ramadurai, J., Shapiro, C., Kozloff, M., and Telfer, M. Zinc abuse and sideroblastic anemia. Am J Hematol. 1993;42(2):227-228.
Perry, A. R., Pagliuca, A., Fitzsimons, E. J., Mufti, G. J., and Williams, R. Acquired sideroblastic anaemia induced by a copper-chelating agent. Int J Hematol. 1996;64(1):69-72.
Rodriguez, E. and Diaz, C. Iron, copper and zinc levels in urine: relationship to various individual factors. J Trace Elem.Med Biol 1995;9(4):200-209.
Van Wouwe, J. P. and Veldhuizen, M. Growth characteristics in laboratory animals fed zinc-deficient, copper-deficient, of histidine-supplemented diets. Biol.Trace Elem.Res. 1996;55(1-2):71-77.
Shackel, N. A., Day, R. O., Kellett, B., and Brooks, P. M. Copper-salicylate gel for pain relief in osteoarthritis: a randomised controlled trial. Med J Aust. 8-4-1997;167(3):134-136.
Christodoulou, J., Danks, D. M., Sarkar, B., Baerlocher, K. E., Casey, R., Horn, N., Tumer, Z., and Clarke, J. T. Early treatment of Menkes disease with parenteral copper-histidine: long-term follow-up of four treated patients. Am J Med Genet. 3-5-1998;76(2):154-164.
Bureau, I., Lewis, C. G., and Fields, M. Effect of hepatic iron on hypercholesterolemia and hypertriacylglycerolemia in copper-deficient fructose-fed rats. Nutrition 1998;14(4):366-371.
Brown, N. A., Bron, A. J., Harding, J. J., and Dewar, H. M. Nutrition supplements and the eye. Eye 1998;12 ( Pt 1):127-133.
Walker, W. R. and Keats, D. M. An investigation of the therapeutic value of the 'copper bracelet'-dermal assimilation of copper in arthritic/rheumatoid conditions. Agents Actions 1976;6(4):454-459.
Institute of Medicine ed. Food and Nutrition Board. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc (2000). National Academy Press;2000.
Patel, A., Dibley, M. J., Mamtani, M., Badhoniya, N., and Kulkarni, H. Zinc and copper supplementation in acute diarrhea in children: a double-blind randomized controlled trial. BMC.Med 2009;7:22.
Shalita AR, Falcon R, Olansky A, Iannotta P, Akhavan A, Day D, Janiga A, Singri P, Kallal JE. Inflammatory acne management with a novel prescription dietary supplement. J Drugs Dermatol. 2012;11(12):1428-33.
Babic Z, Tariba B, Kovacic J, Pizent A, Varnai VM, Macan J. Relevance of serum copper elevation induced by oral contraceptives: a meta-analysis. Contraception. 2013 Jun;87(6):790-800.
Olivares M, Pizarro F, López de Romaña D, Ruz M. Acute copper supplementation does not inhibit non-heme iron bioavailability in humans. Biol Trace Elem Res. 2010 Aug;136(2):180-6.
Pecanac M, Janjic Z, Komarcevic A, Pajic M, Dobanovacki D, Miskovic SS. Burns treatment in ancient times. Med Pregl. 2013 May-Jun;66(5-6):263-7.
Qui Q, Zhang F, Zhu W, Wu J, Liang M. Copper in diabetes mellitus: a meta-analysis and systematic review of plasma and serum studies. Biol Trace Elem Res 2017;177(1):53-63.
Walker-Smith PK, Keith DJ, Kennedy CT, Sansom JE. Allergic contact dermatitis caused by copper. Contact Dermatitis 2016;75(3):186-7.
Olivares M, Figueroa C, Pizarro F. Acute copper and ascorbic acid supplementation inhibits non-heme iron absorption in humans. Biol Trace Elem Res 2016;172(2):315-9.
Patel AB, Dibley MJ, Mamtani M, Badhoniya N, Kulkarni H. Therapeutic zinc and copper supplementation in acute diarrhea does not influence short-term morbidity and growth: double-blind randomized controlled trial. Pediatr Infect Dis J 2013;32(1):91-3.
Squitti R, Simonelli I, Ventriglia M, et al. Meta-analysis of serum non-ceruloplasmin copper in Alzheimer's disease. J Alzheimers Dis 2014;38(4):809-22.
Arendsen LP, Vig S, Thakar R, Sultan AH. Impact of copper compression stockings on venous insufficiency and lipodermatosclerosis: A randomized controlled trial. Phlebology. 2019;34(4):224-230.
Pedro EM, da Rosa Franchi Santos LF, Scavuzzi BM, et al. Trace elements associated with systemic lupus erythematosus and insulin resistance. Biol Trace Elem Res. 2019;191(1):34-44.
Arendsen LP, Thakar R, Bassett P, Sultan AH. The impact of copper impregnated wound dressings on surgical site infection following caesarean section: a double blind randomised controlled study. Eur J Obstet Gynecol Reprod Biol. 2020;251:83-88.
LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Chelating Agents. Accessed on August 25, 2021. Available at: https://www.ncbi.nlm.nih.gov/books/NBK548531/
Gallentine A. Third-degree burn on the neuropathic lower extremity in a patient with diabetes while wearing a copper-containing compression sock: a case report. Wound Manag Prev 2021;67(12):26-29.
Chung KJ, Chin YM, Wong MS, Sanmugam A, Singaravel S, Nah SA. Effectiveness of table salt versus copper sulphate in treating umbilical granuloma: A pilot randomized controlled trial. J Pediatr Surg 2022;57(2):261-265.
Werlenius K, Kinhult S, Solheim TS, et al. Effect of Disulfiram and Copper Plus Chemotherapy vs Chemotherapy Alone on Survival in Patients With Recurrent Glioblastoma: A Randomized Clinical Trial. JAMA Netw Open 2023;6(3):e234149.
Ostwal V, Ramaswamy A, Bhargava P, et al. A pro-oxidant combination of resveratrol and copper reduces chemotherapy-related non-haematological toxicities in advanced gastric cancer: results of a prospective open label phase II single-arm study (RESCU III study). Med Oncol 2022;40(1):17.
Shankar JA, Kaur A, Tyagi L, Selvam S, Hans R, Pannu AK. Severe copper sulphate poisoning: A case rescued with plasmapheresis. Trop Doct 2023;53(2):327-328.
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