Akita, H., Sowa, J., Makiura, M., Akamatsu, H., and Matsunaga, K. Maculopapular drug eruption due to the Japanese herbal medicine Kakkonto (kudzu or arrowroot decoction). Contact Dermatitis 2003;48(6):348-349. View abstract.
An, JR Zhang H Cai XZ Deng Q Fu J Sun Q. Effect observation of Puerarin injection for unstable angina pectoris. Chinese Journal of Clinical Pharmacology and Therapeutics 2001;6(3):2445.
Bao, XM. Observation on curative effects of puerarin injecion in the patients with unstable angina pectoris. Medical Journal of Communications 2003;17(1):12-13.
Bracken, B. K., Penetar, D. M., Maclean, R. R., and Lukas, S. E. Kudzu root extract does not perturb the sleep/wake cycle of moderate drinkers. J Altern Complement Med 2011;17(10):961-966. View abstract.
Carlson, S., Peng, N., Prasain, J. K., and Wyss, J. M. Effects of botanical dietary supplements on cardiovascular, cognitive, and metabolic function in males and females. Gend.Med 2008;5 Suppl A:S76-S90. View abstract.
Chandeying, V. and Lamlertkittikul, S. Challenges in the conduct of Thai herbal scientific study: efficacy and safety of phytoestrogen, pueraria mirifica (Kwao Keur Kao), phase I, in the alleviation of climacteric symptoms in perimenopausal women. J Med Assoc Thai. 2007;90(7):1274-1280. View abstract.
Chandeying, V. and Sangthawan, M. Efficacy comparison of Pueraria mirifica (PM) against conjugated equine estrogen (CEE) with/without medroxyprogesterone acetate (MPA) in the treatment of climacteric symptoms in perimenopausal women: phase III study. J Med Assoc Thai. 2007;90(9):1720-1726. View abstract.
Chao JX, Ye M. Clinical study on Purerain for acute ischemic stroke. Guangdong Med J. 2004;4(3):38-39.
Chen, J., Xu, J., and Li, J. [Effect of puerarin on fibrinolytic activity and lipid peroxide in patients with coronary heart disease]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1999;19(11):649-650. View abstract.
Chen, L., Bi, X. Y., Zhu, L. X., Qiu, Y. Q., Ding, S. J., and Deng, B. Q. [Flavonoids of puerarin versus tanshinone II A for ischemic stroke: a randomized controlled trial]. Zhong.Xi.Yi Jie.He.Xue Bao 2011;9(11):1215-1220. View abstract.
Chen, L., Chai, Q., Zhao, A., and Chai, X. [Effect of puerarin on cerebral blood flow in dogs]. Zhongguo Zhong.Yao Za Zhi. 1995;20(9):560-2, inside. View abstract.
Choo, M. K., Park, E. K., Yoon, H. K., and Kim, D. H. Antithrombotic and antiallergic activities of daidzein, a metabolite of puerarin and daidzin produced by human intestinal microflora. Biol.Pharm.Bull. 2002;25(10):1328-1332. View abstract.
Deng MY. Clinical observation of 48 cases of puerarin for unstable angina pectoris. Hainan Medical Journal 2003;14(1):14-15.
Ding, R. B., Tian, K., Huang, L. L., He, C. W., Jiang, Y., Wang, Y. T., and Wan, J. B. Herbal medicines for the prevention of alcoholic liver disease: a review. J Ethnopharmacol. 12-18-2012;144(3):457-465. View abstract.
Dong PS, Liu YH Song RL Liu FX. Observation on curative effects of puerarin injection on unstable angina pectoris. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care 1999;6(5):355-356.
Dong, L. P. and Wang, T. Y. Effects of puerarin against glutamate excitotoxicity on cultured mouse cerebral cortical neurons. Zhongguo Yao Li Xue.Bao. 1998;19(4):339-342. View abstract.
Duan, S., Li, Y. F., and Luo, X. L. [Effect of puerarin on heart function and serum oxidized-LDL in the patients with chronic cardiac failure]. Hunan.Yi.Ke.Da.Xue.Xue.Bao. 4-28-2000;25(2):176-178. View abstract.
Fan P, Wang L Liu QX. The application of puerarin in the treatment of unstable angina pectoris. Modern Journal of Integrated Chinese Traditional and Western Medicine 1999;8(12):1945-1946.
Guo YJ, Ceng YW Zhao HF. Effect observation of puerarin for unstable angina pectoris. 2000, (5):716-7. Journal of Youjiang Medical College for Nationalities 2000;5:716-717.
Hou, Q., Ao, X., Li, G., and Zhang, Y. [Puerarin combined with avandia for diabetic nephropathy]. Zhong.Nan.Da.Xue Xue Bao Yi Xue Ban. 2012;37(1):73-77. View abstract.
Hsu, H. H., Chang, C. K., Su, H. C., Liu, I. M., and Cheng, J. T. Stimulatory effect of puerarin on alpha1A-adrenoceptor to increase glucose uptake into cultured C2C12 cells of mice. Planta Med 2002;68(11):999-1003. View abstract.
Hu, H. T., Fen, F., and Ding, M. P. [Effects of puerarin with aspirin on the markers of damaged vascular endothelial cells in patients with acute cerebral infarction]. Zhongguo Zhong.Yao Za Zhi 2008;33(23):2827-2829. View abstract.
Huang XF, Lu YL Fan XN Jiang M. Clinical observation of Puerarin for unstable angina pectoris. Journal of Medical Theory and Practice 2002;15(7):776-777.
Jang, M. H., Shin, M. C., Kim, Y. J., Chung, J. H., Yim, S. V., Kim, E. H., Kim, Y., and Kim, C. J. Protective effects of puerariaeflos against ethanol-induced apoptosis on human neuroblastoma cell line SK-N-MC. Jpn.J Pharmacol. 2001;87(4):338-342. View abstract.
Jeon, G. C., Park, M. S., Yoon, D. Y., Shin, C. H., Sin, H. S., and Um, S. J. Antitumor activity of spinasterol isolated from Pueraria roots. Exp Mol.Med 4-30-2005;37(2):111-120. View abstract.
Jiang RY. Clinical observation of 48 cases of puerarin for unstable angina pectoris. 2001;15(3):197-8. Journal of Xianning Medical College 2001;15(3):197-198.
Tomczyk, M., Zovko-Koncic, M., and Chrostek, L. Phytotherapy of alcoholism. Nat.Prod.Commun. 2012;7(2):273-280. View abstract.
Xiao, L. Z., Huang, Z., Ma, S. C., Zen, Z., Luo, B., Lin, X., and Xu, X. [Study on the effect and mechanism of puerarin on the size of infarction in patients with acute myocardial infarction]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2004;24(9):790-792. View abstract.
Xie, R. Q., Du, J., and Hao, Y. M. [Myocardial protection and mechanism of Puerarin Injection on patients of coronary heart disease with ischemia/reperfusion]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2003;23(12):895-897. View abstract.
Xie, W. and Du, L. Diabetes is an inflammatory disease: evidence from traditional Chinese medicines. Diabetes Obes.Metab 2011;13(4):289-301. View abstract.
Xu, X. H. and Zhao, T. Q. Effects of puerarin on D-galactose-induced memory deficits in mice. Acta Pharmacol.Sin. 2002;23(7):587-590. View abstract.
Xue, X. O., Jin, H., Niu, J. Z., and Wang, J. F. [Effects of extracts of root of kudzu vine on mammary gland and uterus development in rats]. Zhongguo Zhong.Yao Za Zhi. 2003;28(6):560-562. View abstract.
Yin, Z. Z. and Zeng, G. Y. [Pharmacology of puerarin. V. Effects of puerarin on platelet aggregation and release of 5-HT from platelets]. Zhongguo Yi.Xue.Ke.Xue.Yuan Xue.Bao. 1981;3 Suppl 1:44-47. View abstract.
Zhang SR, Liu GT Fang JP Hao YM Yan SC Dong L. Effect of puerarin on the endothelin and function of left ventricle in patients with unstable angina pectoris. Information on Traditional Chinese Medicine 2000;7(5):47-49.
Zhang, G. and Fang, S. [Antioxidation of Pueraria lobata isoflavones (PLIs)]. Zhong.Yao Cai. 1997;20(7):358-360. View abstract.
Zheng, G., Zhang, X., Zheng, J., Meng, Q., and Zheng, D. [Estrogen-like effects of puerarin and total isoflavones from Pueraria lobata]. Zhong.Yao Cai. 2002;25(8):566-568. View abstract.
Zhou Y. A summary on 50 cases of unstable angina pectoris treated with combined therapy of Traditional Chinese and Western Medicine. Hunan Journal of Traditional Chinese Medicine 2003;19(2):4-5.
Zhu J, Cheng DH Yang Q Li WS. Clinical observation of puerarin in the treatment of old patients with unstable angina pectoris. Liaoning Drugs and Clinic 2001;4(1):17-18.
Zhu WM, Wu SY. Clinical therapeutic effects of nadroparin calcium combined with isosorbide dinitrate or puerarin on unstable angina pectoris. Chinese Journal of Clinical Pharmacy 2002;11(4):196-199.
Zhu, X. Y., Su, G. Y., Li, Z. H., Yue, T. L., Yan, X. Z., and Wei, H. L. [The metabolic fate of the effective components of puerariae. III. The metabolism of puerarin (author's transl)]. Yao Xue.Xue.Bao. 1979;14(6):349-355. View abstract.
Zhuang, Z. and Jiang, G. Thirty cases of the blood-stasis type prolapse of lumbar intervertebral disc treated by acupuncture at the xi (cleft) point plus herbal intervention injection. J Tradit.Chin Med 2008;28(3):178-182. View abstract.
Akita H, Sowa J, Makiura M, et al. Maculopapular drug eruption due to the Japanese herbal medicine Kakkonto (kudzu or arrowroot decoction). Contact Dermatitis 2003;48:348-9.
Awang DV. Parthenocide: demise of a facile theory of feverfew activity. J Herbs Spices Med Plants 1998;5:95-8.
Benlhabib E, Baker JI, Keyler DE, Singh AK. Kudzu root extract suppresses voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol. J Med Food 2004;7:168-79. View abstract.
Bihlet AR, Byrjalsen I, Andersen JR, et al. The efficacy and safety of multiple dose regimens of kudzu (Pueraria lobata) root extract on bone and cartilage turnover and menopausal symptoms. Front Pharmacol 2021;12:760629. View abstract.
Carai MA, Agabio R, Bombardelli E, et al. Potential use of medicinal plants in the treatment of alcoholism. Fitoterapia 2000;71:S38-42. View abstract.
Chen X. [The clinical observation of puerarin injection on unstable angina pectoris]. Zhong Yao Cai 2004;27:77-8. . View abstract.
Chiang HM, Fang SH, Wen KC, et al. Life-threatening interaction between the root extract of Pueraria lobata and methotrexate in rats. Toxicol Appl Pharmacol 2005;209:263-8. View abstract.
Chueh FS, Chang CP, Chio CC, Lin MT. Puerarin acts through brain serotonergic mechanisms to induce thermal effects. J Pharmacol Sci 2004;96:420-7. View abstract.
Feng R, Chen JH, Liu CH, et al. A combination of Pueraria lobata and Silybum marianum protects against alcoholic liver disease in mice. Phytomedicine. 2019;58:152824. View abstract.
Guerra MC, Speroni E, Broccoli M, et al. Comparison between chinese medical herb Pueraria lobata crude extract and its main isoflavone puerarin antioxidant properties and effects on rat liver CYP-catalysed drug metabolism. Life Sci 2000;67:2997-3006. View abstract.
Heyman GM, Keung WM, Vallee BL. Daidzin decreases ethanol consumption in rats. Alcohol Clin Exp Res 1996;20:1083-7. View abstract.
Hsu FL, Liu IM, Kuo DH, et al. Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats. J Nat Prod 2003;66:788-92. View abstract.
Jaroenporn S, Urasopon N, Watanabe G, Malaivijitnond S. Improvements of vaginal atrophy without systemic side effects after topical application of Pueraria mirifica, a phytoestrogen-rich herb, in postmenopausal cynomolgus macaques. J Reprod Dev. 2014;60(3):238-45. View abstract.
Kim HJ, Kim H, Ahn JH, Suk JH. Liver injury induced by herbal extracts containing mistletoe and kudzu. J Altern Complement Med 2015;21(3):180-5. View abstract.
Lee JS. Supplementation of Pueraria radix water extract on changes of antioxidant enzymes and lipid profile in ethanol-treated rats. Clin Chim Acta 2004;347:121-8. View abstract.
Lee KT, Sohn IC, Kim DH, et al. Hypoglycemic and hypolipidemic effects of tectorigenin and kaikasaponin III in the streptozotocin-lnduced diabetic rat and their antioxidant activity in vitro. Arch Pharm Res 2000;23:461-6. View abstract.
Li SM, Liu B, Chen HF. [Effect of puerarin on plasma endothelin, renin activity and angiotensin II in patients with acute myocardial infarction]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1997;17:339-41. View abstract.
Lin RC, Li TK. Effects of isoflavones on alcohol pharmacokinetics and alcohol-drinking behavior in rats. Am J Clin Nutr 1998;68:1512S-5S. View abstract.
Lukas SE, Penetar D, Berko J, et al. An extract of the Chinese herbal root kudzu reduces alcohol drinking by heavy drinkers in a naturalistic setting. Alcohol Clin Exp Res 2005;29:756-62. View abstract.
Lukas SE, Penetar D, Su Z, Geaghan T, Maywalt M, Tracy M, Rodolico J, Palmer C, Ma Z, Lee DY. A standardized kudzu extract (NPI-031) reduces alcohol consumption in nontreatment-seeking male heavy drinkers. Psychopharmacology (Berl). 2013 Mar;226(1):65-73. View abstract.
Luo ZR, Zheng B. [Effect of Puerarin on platelet activating factors CD63 and CD62P, plasminogen activator inhibitor and C-reactive protein in patients with unstable angia pectoris]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2001;21:31-3 . View abstract.
Overstreet DH, Kralic JE, Morrow AL, et al. NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists. Pharmacol Biochem Behav 2003;75:619-25. View abstract.
Penetar DM, Toto LH, Lee DY, Lukas SE. A single dose of kudzu extract reduces alcohol consumption in a binge drinking paradigm. Drug Alcohol Depend. 2015 Aug 1;153:194-200. View abstract.
Prasain JK, Jones K, Kirk M, et al. Profiling and quantification of isoflavonoids in kudzu dietary supplements by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry. J Agric Food Chem 2003;51:4213-8. View abstract.
Santosh N, Mohan K, Royana S, Yamini TB. Hepatotoxicity of tubers of Indian Kudzu (Pueraria tuberosa) in rats. Food Chem Toxicol. 2010 Apr;48(4):1066-71. View abstract.
Shebek J, Rindone JP. A pilot study exploring the effect of kudzu root on the drinking habits of patients with chronic alcoholism. J Altern Complement Med 2000;6:45-8. View abstract.
Sritonchai C, Manonai J, Sophonsritsuk A, Cherdshewasart W. Comparison of the effects of Pueraria mirifica gel and of placebo gel on the vaginal microenvironment of postmenopausal women with Genitourinary Syndrome of Menopause (GSM). Maturitas. 2020 Oct;140:49-54. View abstract.
Suwanvesh N, Monanai J, Sophonsritsuk A, Cherdshewasart W. Comparison of Pueraria mirifica gel and conjugated equine estrogen cream effects on vaginal health in postmenopausal women. Menopause. 2017 Feb;24(2):210-15. View abstract.
Tan Y, Liu M, Wu B. Puerarin for acute ischaemic stroke. Cochrane Syst Rev 2008;(1):CD004955. View abstract.
Teschke R, Zhang L, Long H, Schwarzenboeck A, Schmidt-Taenzer W, Genthner A, Wolff A, Frenzel C, Schulze J, Eickhoff A. Traditional Chinese Medicine and herbal hepatotoxicity: a tabular compilation of reported cases. Ann Hepatol. 2015 Jan-Feb;14(1):7-19. View abstract.
Tullo V, Curone M, Colombo B, et al. Response of migraine without aura to kudzu. Neurol Sci. 2019 May;40(Suppl 1):203-205. View abstract.
Verma SK, Jain V, Singh DP. Effect of Pueraria tuberosa DC. (Indian Kudzu) on blood pressure, fibrinolysis and oxidative stress in patients with stage 1 hypertension. Pak J Biol Sci. 2012 Aug 1;15(15):742-7. View abstract.
Wang B, Zhu YZ, Li XQ, et al. [Clinical analysis of 5 cases with acute intravascular hemolysis caused by puerarin]. Beijing Da Xue Xue Bao 2004;36:45-6.. View abstract.
Wang D, Qiu L, Wu X, Wei H, Xu F. Evaluation of kudzu root extract-induced hepatotoxicity. J Ethnopharmacol. 2015 Dec 24;176:321-6. View abstract.
Wang LY, Zhao AP, Chai XS. [Effects of puerarin on cat vascular smooth muscle in vitro]. Zhongguo Yao Li Xue Bao 1994;15:180-2. View abstract.
Wang Q, Wu T, Chen X, et al. Puerarin injection for unstable angina pectoris. Cochrane Database Syst Rev 2006;(3):CD004196. [RETRACTED]. View abstract.
Warinsiriruk P, Tantitham C, Cherdshewasart W, Shobeiri SA, Manonai J. Effects of Pueraria mirifica on vaginal artery vascularization in postmenopausal women with genitourinary syndrome of menopause. Maturitas 2022;160:4-10. View abstract.
Woo J, Lau E, Ho SC, et al. Comparison of Pueraria lobata with hormone replacement therapy in treating the adverse health consequences of menopause. Menopause 2003;10:352-61. View abstract.
Xiao BX, Feng L, Cao FR, Pan RL, Liao YH, Liu XM, Chang Q. Pharmacokinetic profiles of the five isoflavonoids from Pueraria lobata roots in the CSF and plasma of rats. J Ethnopharmacol. 2016 May 26;184:22-9. View abstract.
Xie CI, Lin RC, Antony V, et al. Daidzin, an antioxidant isoflavonoid, decreases blood alcohol levels and shortens sleep time induced by ethanol intoxication. Alcohol Clin Exp Res 1994;18:1443-7. View abstract.
Yan B, Wang DY, Xing DM, et al. The antidepressant effect of ethanol extract of radix puerariae in mice exposed to cerebral ischemia reperfusion. Pharmacol Biochem Behav 2004;78:319-25. View abstract.
Yang G, Zhang L, Fan L. [Anti-angina effect of puerarin and its effect on plasma thromboxane A2 and prostacyclin]. Zhong Xi Yi Jie He Za Zhi 1990;10:82-4,68. View abstract.
Ye HY, Qiu F, Zeng J, et al. [Effect of daidzein on antiarrhythmia]. Zhongguo Zhong Yao Za Zhi 2003;28:853-6. View abstract.
Yeh, T. S., Chan, K. H., Hsu, M. C., and Liu, J. F. Supplementation with soybean peptides, taurine, Pueraria isoflavone, and ginseng saponin complex improves endurance exercise capacity in humans. J Med Food 2011;14(3):219-225. View abstract.
Yu Z, Zhang G, Zhao H. [Effects of Puerariae isoflavone on blood viscosity, thrombosis and platelet function]. Zhong Yao Cai 1997;20:468-9. View abstract.
Zhang Y, Chen J, Zhang C, et al. Analysis of the estrogenic components in kudzu root by bioassay and high performance liquid chromatography.J Steroid Biochem Mol Biol 2005;94:375-81. View abstract.
Zhao Z, Yang X, Zhang Y. [Clinical study of puerarin in treatment of patients with unstable angina]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1998;18:282-4. View abstract.
Zheng G, Zhang X, Zheng J, et al. [Hypocholesterolemic effect of total isoflavones from Pueraria lobata in ovariectomized rats]. Zhong Yao Cai 2002;25:273-5. View abstract.
Zheng, J., Chen, B., Jiang, B., Zeng, L., Tang, Z. R., Fan, L., and Zhou, H. H. The effects of puerarin on CYP2D6 and CYP1A2 activities in vivo. Arch Pharm Res 2010;33(2):243-246. View abstract.
Zhou Y, Su X, Cheng B, et al. [Comparative study on pharmacological effects of various species of Pueraria]. Zhongguo Zhong Yao Za Zhi 1995;20:619-21,640. View abstract.
Select a condition to view a list of vitamins
CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
This copyrighted material is licensed from Therapeutic Research Center, LLC. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
Licensed from Therapeutic Research Center, LLC
Copyright © 1995-2024 by Therapeutic Research Center, LLC. All Rights Reserved.