Collagen Type II (native): Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Collagen type II (native) is a protein that is part of the cartilage, bone, and other types of connective tissues in animals and humans.

Collagen type II might work by causing the body to produce chemicals that fight pain and swelling. But this is unproven. Most collagen type II found in supplements comes from chicken. Some collagen type II in supplements comes from cows.

Collagen type II is used for osteoarthritis. It is also used for other types of joint and muscle pain, but there is no good scientific evidence to support these other uses.

Don't confuse collagen type II (native) with collagen peptides, collagen type I (native), or gelatin.

Uses & Effectiveness

Possibly Effective for

Osteoarthritis. Taking collagen type II by mouth for up to 6 months seems to improve self-reported symptoms of osteoarthritis, such as stiffness and pain. But it's not clear if it can prevent the narrowing of the joint in people with osteoarthritis.

Possibly Ineffective for

Rheumatoid arthritis (RA). Taking collagen type II by mouth doesn't improve symptoms of RA. In fact, using it in place of drugs for RA such as methotrexate might make symptoms worse.

There is interest in using collagen type II for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Collagen type II is possibly safe when used short-term. It's been used safely in doses up to 40 mg daily for up to 24 weeks. Some people might have stomach problems after taking collagen type II.

Special Precautions and Warnings

Pregnancy and breast-feeding: There isn't enough reliable information to know if collagen type II is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Collagen allergies: People who are allergic to other types of collagen shouldn't use collagen type II. Other collagen products have been associated with allergic reactions.

Interactions

We currently have no information for Collagen Type II (native) overview.

Dosing

Collagen type II has most often been used by adults in doses of 40 mg by mouth daily for 4-6 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.

View References

REFERENCES:

Barclay TS, Tsourounis C, McCart GM. Glucosamine. Ann Pharmacother 1998;32:574-9.

Barnett ML, Kremer JM, St.Clair W, et al. Treatment of rheumatoid arthritis with oral type II collagen. Arthritis Rheum 1998;41:290-7.

Barnett ML, Combitchi D, Trentham DE. A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis. Arthritis Rheum 1996;39:623-8.

Kalden JR, Sieper J. Oral collagen in the treatment of rheumatoid arthritis [editorial]. Arthritis Rheum 1998;41:191-4.

Trentham DE. Oral tolerization as a treatment of rheumatoid arthritis. Rheum Dis Clin North Am 1998;24:525-36.

Mullins RJ, Richards C, Walker T. Allergic reactions to oral, surgical and topical bovine collagen. Anaphylactic risk for surgeons. Aust N Z J Ophthalmol 1996;24:257-60.

AutoImmune Inc. announces phase III trial results for Colloral. URL https://www.autoimmune.com/clinic/coll.html (Accessed 24 October 1999).

Xie Q, Shi R, Xu G, et al. Effects of AR7 Joint Complex on arthralgia for patients with osteoarthritis: results of a three-month study in Shanghai, China. Nutr J. 2008 Oct 27;7:31.

McKown, K. M., Carbone, L. D., Kaplan, S. B., Aelion, J. A., Lohr, K. M., Cremer, M. A., Bustillo, J., Gonzalez, M., Kaeley, G., Steere, E. L., Somes, G. W., Myers, L. K., Seyer, J. M., Kang, A. H., and Postlethwaite, A. E. Lack of efficacy of oral bovine type II collagen added to existing therapy in rheumatoid arthritis. Arthritis Rheum 1999;42(6):1204-1208.

Zhang, L. L., Wei, W., Xiao, F., Xu, J. H., Bao, C. D., Ni, L. Q., and Li, X. F. A randomized, double-blind, multicenter, controlled clinical trial of chicken type II collagen in patients with rheumatoid arthritis. Arthritis Rheum 7-15-2008;59(7):905-910.

Trentham, D. E., Dynesius-Trentham, R. A., Orav, E. J., Combitchi, D., Lorenzo, C., Sewell, K. L., Hafler, D. A., and Weiner, H. L. Effects of oral administration of type II collagen on rheumatoid arthritis. Science 9-24-1993;261(5129):1727-1730.

Hauselmann, H. J., Caravatti, M., Seifert, B., Wang, K., Bruckner, P., Stucki, G., and Michel, B. A. Can collagen type II sustain a methotrexate-induced therapeutic effect in patients with long-standing rheumatoid arthritis? A double-blind, randomized trial. Br J Rheumatol 1998;37(10):1110-1117.

Crowley DC, Lau FC, Sharma P, Evans M, Guthrie N, Bagchi M, et al Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int J Med Sci. 2009 Oct 9;6(6):312-21.

Lugo JP, Saiyed ZM, Lane NE. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study.Nutr J. 2016;15:14. doi: 10.1186/s12937-016-0130-8.

Wei W, Zhang LL, Xu JH, et al. A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis. Arthritis Res Ther. 2009;11(6):R180.

Cazzola M, Antivalle M, Sarzi-Puttini P, Dell'Acqua D, Panni B, Caruso I. Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study. Clin Exp Rheumatol. 2000;18(5):571-7.

Thompson DJ, Barron KS, Whitcup SM, Robinson MR. The safety and efficacy of chicken type II collagen on uveitis associated with juvenile rheumatoid arthritis. Ocul Immunol Inflamm. 2002;10(2):83-91.

Lugo JP, Saiyed ZM, Lau FC, et al. Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. J Int Soc Sports Nutr. 2013;10(1):48.

Rui F, Jiawei K, Yuntao H, et al. Undenatured type II collagen prevents and treats osteoarthritis and motor function degradation in T2DM patients and db/db mice. Food Funct 2021;12(10):4373-4391.

Fan R, Hao Y, Liu X, et al. Undenatured Type II Collagen Relieves Bone Impairment through Improving Inflammation and Oxidative Stress in Ageing db/db Mice. Molecules 2021;26(16):4942.

Harris RB, Fonseca FLA, Sharp MH, Ottinger CR. Functional Characterization of Undenatured Type II Collagen Supplements: Are They Interchangeable?. J Diet Suppl 2021.

Orhan C, Juturu V, Sahin E, et al. Undenatured Type II Collagen Ameliorates Inflammatory Responses and Articular Cartilage Damage in the Rat Model of Osteoarthritis. Front Vet Sci 2021;8:617789.

Schön C, Knaub K, Alt W, Durkee S, Saiyed Z, Juturu V. UC-II Undenatured Type II Collagen for Knee Joint Flexibility: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study. J Integr Complement Med 2022;28(6):540-548.

Shiojima Y, Takahashi M, Takahashi R, et al. Efficacy and Safety of Dietary Undenatured Type II Collagen on Joint and Motor Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study. J Am Nutr Assoc 2023;42(3):224-241.

Santana ÉTN, da Cunha Machado S, Brandão Lima VN, et al. Comparison between exercise therapy and non-hydrolyzed collagen (UC-II) in functionality and quality of life in women with knee osteoarthritis: A randomized controlled clinical trial. Wien Klin Wochenschr. 2022 May 25. Epub ahead of print.

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