Mastic: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Mastic (Pistacia lentiscus) is an evergreen shrub found throughout the Mediterranean. The sap (resin) from its trunk is used to make medicine.

Mastic might help reduce stomach acid and protect the lining of the stomach and intestine. It might also have antibacterial effects and reduce swelling.

People use mastic for stomach ulcers, indigestion, Crohn disease, wound healing, and many other conditions, but there is no good scientific evidence to support most of these uses.

Don't confuse mastic with gum arabic. These are not the same.

Uses & Effectiveness

Possibly Effective for

Indigestion (dyspepsia). Taking mastic gum by mouth seems to reduce symptoms of indigestion, including stomach pain and heartburn.

There is interest in using mastic for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Mastic is possibly safe when used for up to 3 months. It seems to be well-tolerated. Side effects might include constipation.

When applied to the skin: There isn't enough reliable information to know if mastic is safe. Some people might experience an itchy rash after using mastic gum.

Special Precautions and Warnings

Pregnancy and breast-feeding: There isn't enough reliable information to know if mastic is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Allergy to to other plants: People who are allergic to a plant called Schinus terebinthifolious or to Pistacia species might also be allergic to mastic tree.

Interactions

We currently have no information for Mastic overview.

Dosing

Mastic gum or powder have most often been used by adults in doses of 1-2.8 grams by mouth daily for up to 3 months. Mastic has also been used as an essential oil in toothpaste. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.

View References

REFERENCES:

The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Keynan N, Tamir R, Waisel Y, et al. Allergenicity of the pollen of Pistacia. Allergy 1997;52:323-30.

Iauk L, Ragusa S, Rapisarda A, et al. In vitro antimicrobial activity of Pistacia lentiscus L. extracts: preliminary report. J Chemother 1996;8:207-9.

Al-Said MS, Ageel AM, Parmar NS, Tariq M. Evaluation of mastic, a crude drug obtained from Pistacia lentiscus for gastric and duodenal anti-ulcer activity. J Ethnopharmacol 1986;15:271-8.

Sterer, N., Nuas, S., Mizrahi, B., Goldenberg, C., Weiss, E. I., Domb, A., and Davidi, M. P. Oral malodor reduction by a palatal mucoadhesive tablet containing herbal formulation. J Dent. 2008;36(7):535-539.

Ali-Shtayeh, M. S. and Abu Ghdeib, S. I. Antifungal activity of plant extracts against dermatophytes. Mycoses 1999;42(11-12):665-672.

Takahashi, K., Fukazawa, M., Motohira, H., Ochiai, K., Nishikawa, H., and Miyata, T. A pilot study on antiplaque effects of mastic chewing gum in the oral cavity. J Periodontol. 2003;74(4):501-505.

Koutsoudaki, C., Krsek, M., and Rodger, A. Chemical composition and antibacterial activity of the essential oil and the gum of Pistacia lentiscus Var. chia. J Agric.Food Chem 10-5-2005;53(20):7681-7685.

Aksoy, A., Duran, N., and Koksal, F. In vitro and in vivo antimicrobial effects of mastic chewing gum against Streptococcus mutans and mutans streptococci. Arch Oral Biol 12-15-2005;

Balan, K. V., Prince, J., Han, Z., Dimas, K., Cladaras, M., Wyche, J. H., Sitaras, N. M., and Pantazis, P. Antiproliferative activity and induction of apoptosis in human colon cancer cells treated in vitro with constituents of a product derived from Pistacia lentiscus L. var. chia. Phytomedicine. 2007;14(4):263-272.

Sterer, N. Antimicrobial effect of mastic gum methanolic extract against Porphyromonas gingivalis. J Med Food 2006;9(2):290-292.

Loutrari, H., Magkouta, S., Pyriochou, A., Koika, V., Kolisis, F. N., Papapetropoulos, A., and Roussos, C. Mastic oil from Pistacia lentiscus var. chia inhibits growth and survival of human K562 leukemia cells and attenuates angiogenesis. Nutr Cancer 2006;55(1):86-93.

Paraschos, S., Magiatis, P., Mitakou, S., Petraki, K., Kalliaropoulos, A., Maragkoudakis, P., Mentis, A., Sgouras, D., and Skaltsounis, A. L. In vitro and in vivo activities of Chios mastic gum extracts and constituents against Helicobacter pylori. Antimicrob.Agents Chemother. 2007;51(2):551-559.

Triantafyllou, A., Chaviaras, N., Sergentanis, T. N., Protopapa, E., and Tsaknis, J. Chios mastic gum modulates serum biochemical parameters in a human population. J Ethnopharmacol. 4-20-2007;111(1):43-49.

Kaliora, A. C., Stathopoulou, M. G., Triantafillidis, J. K., Dedoussis, G. V., and Andrikopoulos, N. K. Chios mastic treatment of patients with active Crohn's disease. World J Gastroenterol. 2-7-2007;13(5):748-753.

He, M. L., Chen, W. W., Zhang, P. J., Jiang, A. L., Fan, W., Yuan, H. Q., Liu, W. W., and Zhang, J. Y. Gum mastic increases maspin expression in prostate cancer cells. Acta Pharmacol.Sin. 2007;28(4):567-572.

Barra, A., Coroneo, V., Dessi, S., Cabras, P., and Angioni, A. Characterization of the volatile constituents in the essential oil of Pistacia lentiscus L. from different origins and its antifungal and antioxidant activity. J Agric.Food Chem 8-22-2007;55(17):7093-7098.

Kaliora, A. C., Stathopoulou, M. G., Triantafillidis, J. K., Dedoussis, G. V., and Andrikopoulos, N. K. Alterations in the function of circulating mononuclear cells derived from patients with Crohn's disease treated with mastic. World J Gastroenterol. 12-7-2007;13(45):6031-6036.

Kottakis, F., Kouzi-Koliakou, K., Pendas, S., Kountouras, J., and Choli-Papadopoulou, T. Effects of mastic gum Pistacia lentiscus var. Chia on innate cellular immune effectors. Eur.J Gastroenterol.Hepatol. 2009;21(2):143-149.

Dimas, K., Hatziantoniou, S., Wyche, J. H., and Pantazis, P. A mastic gum extract induces suppression of growth of human colorectal tumor xenografts in immunodeficient mice. In Vivo 2009;23(1):63-68.

Zhou, L., Satoh, K., Takahashi, K., Watanabe, S., Nakamura, W., Maki, J., Hatano, H., Takekawa, F., Shimada, C., and Sakagami, H. Re-evaluation of anti-inflammatory activity of mastic using activated macrophages. In Vivo 2009;23(4):583-589.

Magkouta, S., Stathopoulos, G. T., Psallidas, I., Papapetropoulos, A., Kolisis, F. N., Roussos, C., and Loutrari, H. Protective effects of mastic oil from Pistacia lentiscus variation chia against experimental growth of lewis lung carcinoma. Nutr Cancer 2009;61(5):640-648.

Dabos, K. J., Sfika, E., Vlatta, L. J., and Giannikopoulos, G. The effect of mastic gum on Helicobacter pylori: a randomized pilot study. Phytomedicine. 2010;17(3-4):296-299.

Dabos, K. J., Sfika, E., Vlatta, L. J., Frantzi, D., Amygdalos, G. I., and Giannikopoulos, G. Is Chios mastic gum effective in the treatment of functional dyspepsia? A prospective randomised double-blind placebo controlled trial. J Ethnopharmacol. 2-3-2010;127(2):205-209.

Moulos, P., Papadodima, O., Chatziioannou, A., Loutrari, H., Roussos, C., and Kolisis, F. N. A transcriptomic computational analysis of mastic oil-treated Lewis lung carcinomas reveals molecular mechanisms targeting tumor cell growth and survival. BMC.Med Genomics 2009;2:68.

Huang, X. Y., Wang, H. C., Yuan, Z., Li, A., He, M. L., Ai, K. X., Zheng, Q., and Qin, H. L. Gemcitabine combined with gum mastic causes potent growth inhibition and apoptosis of pancreatic cancer cells. Acta Pharmacol.Sin. 2010;31(6):741-745.

Qiao, J., Li, A., Jin, X., and Wang, J. Mastic Alleviates Allergic Inflammation in Asthmatic Model Mice by Inhibiting Recruitment of Eosinophils. Am J Respir.Cell Mol Biol 9-20-2010;

Mahmoudi, M., Ebrahimzadeh, M. A., Nabavi, S. F., Hafezi, S., Nabavi, S. M., and Eslami, Sh. Antiinflammatory and antioxidant activities of gum mastic. Eur.Rev.Med Pharmacol.Sci 2010;14(9):765-769.

Gioxari, A., Kaliora, A. C., Papalois, A., Agrogiannis, G., Triantafillidis, J. K., and Andrikopoulos, N. K. Pistacia lentiscus Resin Regulates Intestinal Damage and Inflammation in Trinitrobenzene Sulfonic Acid-Induced Colitis. J Med Food 5-25-2011;

Triantafyllou, A., Bikineyeva, A., Dikalova, A., Nazarewicz, R., Lerakis, S., and Dikalov, S. Anti-inflammatory activity of Chios mastic gum is associated with inhibition of TNF-alpha induced oxidative stress. Nutr J 2011;10:64.

Huwez, F. U. and Al Habbal, M. J. Mastic in treatment of benign gastric ulcers. Gastroenterol.Jpn. 1986;21(3):273-274.

Al Habbal, M. J., Al Habbal, Z., and Huwez, F. U. A double-blind controlled clinical trial of mastic and placebo in the treatment of duodenal ulcer. Clin Exp Pharmacol.Physiol 1984;11(5):541-544.

Huwez, F. U., Thirlwell, D., Cockayne, A., and Ala'Aldeen, D. A. Mastic gum kills Helicobacter pylori. N.Engl.J Med 12-24-1998;339(26):1946.

Watanabe, H., Hagiwara, S., Fukuda, M., Yuichi, I., Tamura, N., Suzuki, M., and Kawasaki, D. Double blind randomized control test for the usefulness of mastic compound dentifrice against periodontitis under using sonic toothbrush 2010. Yakuri to chiryo 2010;38(10):915-925.

Papada E, Forbes A, Amerikanou C, et al. Antioxidative efficacy of a Pistacia lentiscus supplement and its effect on the plasma amino acid profile in inflammatory bowel disease: A randomised, double-blind, placebo-controlled trial. Nutrients. 2018;10(11). pii: E1779.

Papada E, Gioxari A, Amerikanou C, et al. Regulation of faecal biomarkers in inflammatory bowel disease patients treated with oral mastiha (Pistacia lentiscus) supplement: A double-blind and placebo-controlled randomised trial. Phytother Res. 2019;33(2):360-369.

Papada E, Gioxari A, Brieudes V, et al. Bioavailability of terpenes and postprandial effect on human antioxidant potential. An open-label study in healthy subjects. Mol Nutr Food Res. 2018;62(3).

Hazan Z, Adamsky K, Lucassen A, Levin LA. A first-in-human phase 1 randomized single and multiple ascending dose study of RPh201 in healthy volunteers. Clin Pharmacol Drug Dev. 2020;9(3):366-74.

Granger C, Starace M, Alessandrini A, et al. Efficacy and acceptability of a new water-soluble nail strengthener containing Pistacia lentiscus and hyaluronic acid to improve the appearance of brittle nails versus untreated nails: in vitro and clinical evidence. Skin Appendage Disord. 2020;6(2):108-14.

Piraccini BM, Granger C, Alessandrini A, et al. Clinical and instrumental objective evidence of the efficacy of a new water-based nail-strengthening solution containing Pistacia lentiscus and hyaluronic acid applied for up to 6 months to improve the appearance of weak, brittle nails. Dermatol Ther (Heidelb). 2020;10(1):119-31.

Moraschini V, Kischinhevsky ICC, Calasans-Maia MD, et al. Ineffectiveness of ozone therapy in nonsurgical periodontal treatment: a systematic review and metaanalysis of randomized clinical trials. Clin Oral Investig 2020;24(6):1877-1888.

Ostovan M, Fazljou SMB, Khazraei H, Araj Khodaei M, Torbati M. The Anti-Inflammatory Effect of Pistacia Lentiscus in a Rat Model of Colitis. J Inflamm Res 2020;13:369-376.

Amerikanou C, Kanoni S, Kaliora AC, et al. Effect of Mastiha supplementation on NAFLD: The MAST4HEALTH Randomised, Controlled Trial. Mol Nutr Food Res 2021;65(10):e2001178.

Boutemine IM, Amri M, Dorgham K, et al. Beneficial role of Pistacia lentiscus aqueous extract in experimental colitis: anti-inflammatory and potential therapeutic effects. Inflammopharmacology 2021;29(4):1225-1239.

Pepe AE, Lelovas P, Pachi VK, et al. Chios mastic gum consumption has a protective effect on ovariectomy-induced bone loss in rats. Prev Nutr Food Sci 2021;26(2):166-76.

Kishimoto R, Kato N, Koike M, Iwashita N, Takagi Y, Fukuyama T. Topical treatment with mastic (resin from Pistacia lentiscus) elicits anti-inflammatory and anti-pruritic responses by modulating keratinocyte activation in a mouse model of allergic dermatitis. Phytomedicine 2021;91:153679.

Gioxari A, Amerikanou C, Valsamidou E, et al. Chios mastiha essential oil exhibits antihypertensive, hypolipidemic and anti-obesity effects in metabolically unhealthy adults - a randomized controlled trial. Pharmacol Res 2023;194:106821.

Kartalis A, Afendoulis D, Didagelos M, et al. Effects of Chios Mastiha essential oil on cholesterol levels of healthy volunteers: A prospective, randomized, placebo-controlled study. (MASTIHA-OIL). Hellenic J Cardiol 2023.

Tsironi K, Mylonopoulou IM, Pandis N, Vassilopoulos S, Sifakakis I, Papaioannou W. The effect of mastic mouthwash on halitosis and oral hygiene in orthodontic patients: a randomized clinical trial. Eur J Orthod 2023.

Cui H, Li X, An XR, Liu W, Yuan T. Masticadienonic acid from Chios mastic gum mitigates colitis in mice via modulating inflammatory response, gut barrier integrity and microbiota. Phytomedicine 2023;108:154518.

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