Overview

Methylsulfonylmethane (MSM) is a chemical that occurs naturally in humans, as well as some green plants and animals. It can also be made in a lab.

MSM might supply sulfur to make other chemicals in the body. But there is no recommended dietary allowance (RDA) for MSM or sulfur, and sulfur deficiency is not a known condition.

People commonly use MSM for osteoarthritis. It is also used for pain, swelling, aging skin, hay fever, and many other conditions, but there is no good scientific evidence to support most of these uses.

Don't confuse MSM with DMSO (Dimethylsulfoxide). They are not the same compound.



Uses & Effectiveness

Possibly Effective for

  • Osteoarthritis. Taking MSM by mouth, alone or together with other ingredients such as glucosamine, can slightly reduce pain and swelling and improve function in people with osteoarthritis.

Possibly Ineffective for

  • Poor circulation that can cause the legs to swell (chronic venous insufficiency or CVI). Applying MSM and EDTA to the skin can reduce swelling in people with CVI. But applying MSM alone seems to make swelling worse.

There is interest in using MSM for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: MSM is possibly safe when used for up to 6 months. In some people, MSM might cause nausea, diarrhea, bloating, and stomach discomfort.

When applied to the skin: MSM is possibly safe when used in combination with other ingredients, such as silymarin or hyaluronic acid and tea tree oil, for up to 20 days.

Special Precautions and Warnings

When taken by mouth: MSM is possibly safe when used for up to 6 months. In some people, MSM might cause nausea, diarrhea, bloating, and stomach discomfort.

When applied to the skin: MSM is possibly safe when used in combination with other ingredients, such as silymarin or hyaluronic acid and tea tree oil, for up to 20 days.

Pregnancy and breast-feeding: There isn't enough reliable information to know if MSM is safe to use when pregnant or breast feeding. Stay on the safe side and avoid use.

Varicose veins and other circulatory problems (chronic venous insufficiency): Applying a lotion that contains MSM to the lower limbs can increase swelling and pain in people with varicose veins and other circulatory problems.

Interactions

We currently have no information for Methylsulfonylmethane (MSM) overview.

Dosing

MSM has most often been used by adults in doses of 1-6 grams by mouth daily for up to 16 weeks. MSM is also available in combination products, and topical creams and gels. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.
View References

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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