Lucas A, Stafford M, Morley R, et al. Efficacy and safety of long-chain polyunsaturated fatty acid supplementation of infant-formula milk: a randomized trial. Lancet 1999;354:1948-54.
Gibson RA. Long-chain polyunsaturated fatty acids and infant development (editorial). Lancet 1999;354:1919.
Godley PA. Essential fatty acid consumption and risk of breast cancer. Breast Cancer Res Treat 1995;35:91-5.
Malloy MJ, Kane JP. Agents used in hyperlipidemia. In: B. Katzung, ed. Basic and Clinical Pharmacology. 4th ed. Norwald, CT: Appleton and Lange, 1989.
Rose DP. The mechanistic rationale in support of dietary cancer prevention. Prev Med 1996;25:34-7.
Noguchi M, Rose DP, Earashi M, Miyazaki I. The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. Oncology 1995;52:265-71.
Leventhal LJ, Boyce EG, Zurier RB. Treatment of rheumatoid arthritis with gammalinolenic acid. Ann Intern Med 1993;119:867-73.
Newcomer LM, King IB, Wicklund KG, Stanford JL. The association of fatty acids with prostate cancer risk. Prostate 2001;47:262-8.
Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Washington, DC: National Academy Press, 2002. Available at: https://www.nap.edu/books/0309085373/html/.
Richardson AJ, Montgomery P. The Oxford-Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics 2005;115:1360-6.
Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate. Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: National Academy Press, 2005. Available at: https://www.nap.edu/books/0309069351/html/
Colter, A. L., Cutler, C., and Meckling, K. A. Fatty acid status and behavioural symptoms of attention deficit hyperactivity disorder in adolescents: a case-control study. Nutr J 2008;7:8.
Yamada, T., Strong, J. P., Ishii, T., Ueno, T., Koyama, M., Wagayama, H., Shimizu, A., Sakai, T., Malcom, G. T., and Guzman, M. A. Atherosclerosis and omega-3 fatty acids in the populations of a fishing village and a farming village in Japan. Atherosclerosis 2000;153(2):469-481.
Conklin, S. M., Manuck, S. B., Yao, J. K., Flory, J. D., Hibbeln, J. R., and Muldoon, M. F. High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. Psychosom.Med. 2007;69(9):932-934.
Aupperle, R. L., Denney, D. R., Lynch, S. G., Carlson, S. E., and Sullivan, D. K. Omega-3 fatty acids and multiple sclerosis: relationship to depression. J Behav Med 2008;31(2):127-135.
Johnson, M., Ostlund, S., Fransson, G., Kadesjo, B., and Gillberg, C. Omega-3/omega-6 fatty acids for attention deficit hyperactivity disorder: a randomized placebo-controlled trial in children and adolescents. J.Atten.Disord. 2009;12(5):394-401.
Margolin, G., Huster, G., Glueck, C. J., Speirs, J., Vandegrift, J., Illig, E., Wu, J., Streicher, P., and Tracy, T. Blood pressure lowering in elderly subjects: a double-blind crossover study of omega-3 and omega-6 fatty acids. Am J Clin Nutr 1991;53(2):562-572.
Ventura, H. O., Milani, R. V., Lavie, C. J., Smart, F. W., Stapleton, D. D., Toups, T. S., and Price, H. L. Cyclosporine-induced hypertension. Efficacy of omega-3 fatty acids in patients after cardiac transplantation. Circulation 1993;88(5 Pt 2):II281-II285.
Hodge, L., Salome, C. M., Hughes, J. M., Liu-Brennan, D., Rimmer, J., Allman, M., Pang, D., Armour, C., and Woolcock, A. J. Effect of dietary intake of omega-3 and omega-6 fatty acids on severity of asthma in children. Eur Respir.J 1998;11(2):361-365.
Munoz, S. E., Piegari, M., Guzman, C. A., and Eynard, A. R. Differential effects of dietary Oenothera, Zizyphus mistol, and corn oils, and essential fatty acid deficiency on the progression of a murine mammary gland adenocarcinoma. Nutrition 1999;15(3):208-212.
Richardson, A. J., Cyhlarova, E., and Ross, M. A. Omega-3 and omega-6 fatty acid concentrations in red blood cell membranes relate to schizotypal traits in healthy adults. Prostaglandins Leukot.Essent.Fatty Acids 2003;69(6):461-466.
Melnik, B. and Plewig, G. Are disturbances of omega-6-fatty acid metabolism involved in the pathogenesis of atopic dermatitis? Acta Derm.Venereol.Suppl (Stockh) 1992;176:77-85.
Assies, J., Lok, A., Bockting, C. L., Weverling, G. J., Lieverse, R., Visser, I., Abeling, N. G., Duran, M., and Schene, A. H. Fatty acids and homocysteine levels in patients with recurrent depression: an explorative pilot study. Prostaglandins Leukot.Essent.Fatty Acids 2004;70(4):349-356.
Chiplonkar, S. A., Agte, V. V., Tarwadi, K. V., Paknikar, K. M., and Diwate, U. P. Micronutrient deficiencies as predisposing factors for hypertension in lacto-vegetarian Indian adults. J Am Coll.Nutr 2004;23(3):239-247.
Grimble, R. F. Immunonutrition. Curr Opin.Gastroenterol 2005;21(2):216-222.
Hughes-Fulford, M., Tjandrawinata, R. R., Li, C. F., and Sayyah, S. Arachidonic acid, an omega-6 fatty acid, induces cytoplasmic phospholipase A2 in prostate carcinoma cells. Carcinogenesis 2005;26(9):1520-1526.
Mamalakis, G., Kiriakakis, M., Tsibinos, G., Hatzis, C., Flouri, S., Mantzoros, C., and Kafatos, A. Depression and serum adiponectin and adipose omega-3 and omega-6 fatty acids in adolescents. Pharmacol.Biochem.Behav. 2006;85(2):474-479.
Okuyama, H., Ichikawa, Y., Sun, Y., Hamazaki, T., and Lands, W. E. Cancers common in the USA are stimulated by omega 6 fatty acids and large amounts of animal fats, but suppressed by omega 3 fatty acids and cholesterol. World Rev Nutr Diet. 2007;96:143-149.
Farinotti, M., Simi, S., Di, Pietrantonj C., McDowell, N., Brait, L., Lupo, D., and Filippini, G. Dietary interventions for multiple sclerosis. Cochrane.Database.Syst.Rev 2007;(1):CD004192.
Martinez-Ramirez, M. J., Palma, S., Martinez-Gonzalez, M. A., Delgado-Martinez, A. D., de la Fuente, C., and Delgado-Rodriguez, M. Dietary fat intake and the risk of osteoporotic fractures in the elderly. Eur.J Clin Nutr 2007;61(9):1114-1120.
Sonestedt, E., Gullberg, B., and Wirfalt, E. Both food habit change in the past and obesity status may influence the association between dietary factors and postmenopausal breast cancer. Public Health Nutr 2007;10(8):769-779.
Pinna, A., Piccinini, P., and Carta, F. Effect of oral linoleic and gamma-linolenic acid on meibomian gland dysfunction. Cornea 2007;26(3):260-264.
Nielsen, A. A., Nielsen, J. N., Gronbaek, H., Eivindson, M., Vind, I., Munkholm, P., Brandslund, I., and Hey, H. Impact of enteral supplements enriched with omega-3 fatty acids and/or omega-6 fatty acids, arginine and ribonucleic acid compounds on leptin levels and nutritional status in active Crohn's disease treated with prednisolone. Digestion 2007;75(1):10-16.
Laidler, P., Dulinska, J., and Mrozicki, S. Does the inhibition of c-myc expression mediate the anti-tumor activity of PPAR's ligands in prostate cancer cell lines? Arch.Biochem.Biophys. 6-1-2007;462(1):1-12.
Simopoulos, A. P. The omega-6/omega-3 fatty acid ratio, genetic variation, and cardiovascular disease. Asia Pac.J Clin Nutr 2008;17 Suppl 1:131-134.
Querques, G., Russo, V., Barone, A., Iaculli, C., and Delle, Noci N. [Efficacy of omega-6 essential fatty acid treatment before and after photorefractive keratectomy]. J Fr Ophtalmol. 2008;31(3):282-286.
Harris, W. S., Mozaffarian, D., Rimm, E., Kris-Etherton, P., Rudel, L. L., Appel, L. J., Engler, M. M., Engler, M. B., and Sacks, F. Omega-6 fatty acids and risk for cardiovascular disease: a science advisory from the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on Epidemiology and Prevention. Circulation 2-17-2009;119(6):902-907.
Raz, R. and Gabis, L. Essential fatty acids and attention-deficit-hyperactivity disorder: a systematic review. Dev.Med Child Neurol. 2009;51(8):580-592.
Tso, P. and Hayashi, H. The physiology and regulation of the intestinal absorption and transport of omega-3 and omega-6 fatty acids. Adv.Prostaglandin Thromboxane Leukot.Res 1989;19:623-626.
Gibson, R. A., Teubner, J. K., Haines, K., Cooper, D. M., and Davidson, G. P. Relationships between pulmonary function and plasma fatty acid levels in cystic fibrosis patients. J Pediatr Gastroenterol Nutr 1986;5(3):408-415.
Peck, M. D., Mantero-Atienza, E., Miguez-Burbano, M. J., Lu, Y., Fletcher, M. A., Shor-Posner, G., and Baum, M. K. The esterified plasma fatty acid profile is altered in early HIV-1 infection. Lipids 1993;28(7):593-597.
Godley, P. A., Campbell, M. K., Gallagher, P., Martinson, F. E., Mohler, J. L., and Sandler, R. S. Biomarkers of essential fatty acid consumption and risk of prostatic carcinoma. Cancer Epidemiol.Biomarkers Prev. 1996;5(11):889-895.
Socha, P., Koletzko, B., Swiatkowska, E., Pawlowska, J., Stolarczyk, A., and Socha, J. Essential fatty acid metabolism in infants with cholestasis. Acta Paediatr. 1998;87(3):278-283.
Willatts P, Forsyth S, Agostoni C, Casaer P, Riva, E, Boehm G. Effects of long-chain PUFA supplementation in infant formula on cognitive function in later childhood. Am J Clin Nutr. 2013;98(suppl):536S-42S.
Lapillonne A, Pastor N, Zhuang W, Scalabrin DMF. Infants fed formula with added long chain polyunsaturated fatty acids have reduced incidence of respiratory illnesses and diarrhea during the first year of life. BMC Pediatr. 2014;14:168.
Lee E, Kim H, Kim H, Ha EH, Chang N. Association of maternal omega-6 fatty acid intake with infant birth outcomes: Korean Mothers and Children's Environmental Health (MOCEH). Nutr J 2018;17(1):47.
Wu JHY, Marklund M, Imamura F, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Fatty Acids and Outcomes Research Consortium (FORCE). Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39?740 adults from 20 prospective cohort studies. Lancet Diabetes Endocrinol 2017;5(12):965-74.
Pawelczyk T, Trafalska E, Pawelczyk A, Kotlicka-Antczak M. Differences in omega-3 and omega-6 polyunsaturated fatty acid consumption in people at ultra-high risk of psychosis, first-episode schizophrenia, and in healthy controls. Early Interv Psychiatry 2017;11(6):498-508.
Lemoine Soto CM, Woo H, Romero K, et al. Association of omega-3 and omega-6 fatty acid intake with inflammation and respiratory outcomes in COPD. Am J Resp Crit Care Med. 2018;197:A3139.
Delgado GE, März W, Lorkowski S, von Schacky C, Kleber ME. Omega-6 fatty acids: opposing associations with risk-The Ludwigshafen Risk and Cardiovascular Health Study. J Clin Lipidol 2017;11(4):1082-90.e14.
Moon K, Rao SC, Schulzke SM, Patole SK, Simmer K. Longchain polyunsaturated fatty acid supplementation in preterm infants. Cochrane Database Syst Rev 2016;12:CD000375.
Jasani B, Simmer K, Patole SK, Rao SC. Long chain polyunsaturated fatty acid supplementation in infants born at term. Cochrane Database Syst Rev 2017;3:CD000376.
Hooper L, Al-Khudairy L, Abdelhamid AS, et al. Omega-6 fats for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2018;11:CD011094.
Harris WS, Tintle NL, Ramachandran VS. Erythrocyte n-6 fatty acids and risk for cardiovascular outcomes and total mortality in the Framingham heart study. Nutrients. 2018;10(12). pii: E2012.
Nakamura H, Hara A, Tsujiguchi H, et al. Relationship between dietary n-6 fatty acid intake and hypertension: Effect of glycated hemoglobin levels. Nutrients. 2018;10(12). pii: E1825.
Rutting S, Papanicolaou M, Xenaki D, et al. Dietary ?-6 polyunsaturated fatty acid arachidonic acid increases inflammation, but inhibits ECM protein expression in COPD. Respir Res. 2018;19(1):211.
Rutting S, Xenaki D, Lau E, et al. Dietary omega-6, but not omega-3, polyunsaturated or saturated fatty acids increase inflammation in primary lung mesenchymal cells. Am J Physiol Lung Cell Mol Physiol. 2018;314(6):L922-L935.
Ziemanski JF, Wolters LR, Jones-Jordan L, Nichols JJ, Nichols KK. Relation between dietary essential fatty acid intake and dry eye disease and meibomian gland dysfunction in postmenopausal women. Am J Ophthalmol. 2018;189:29-40.
Assmann KE, Adjibade M, Hercberg S, Galan P, Kesse-Guyot E. Unsaturated fatty acid intakes during midlife are positively associated with later cognitive function in older adults with modulating effects of antioxidant supplementation. J Nutr. 2018;148(12):1938-1945.
Henderson G, Crofts C, Schofield G. Linoleic acid and diabetes prevention. Lancet Diabetes Endocrinol. 2018;6(1):12-13.
Brown TJ, Brainard J, Song F, et al. Omega-3, omega-6, and total dietary polyunsaturated fat for prevention and treatment of type 2 diabetes mellitus: systematic review and meta-analysis of randomised controlled trials. BMJ. 2019;366:l4697.
Dong X, Li S, Chen J, Li Y, Wu Y, Zhang D. Association of dietary ω-3 and ω-6 fatty acids intake with cognitive performance in older adults: National Health and nutrition examination Survey (NHANES) 2011-2014. Nutr J. 2020;19(1):25.
Gardner KG, Gebretsadik T, Hartman TJ, et al. Prenatal omega-3 and omega-6 polyunsaturated fatty acids and childhood atopic dermatitis. J Allergy Clin Immunol Pract. 2020;8(3):937-944.
Luo J, Ge H, Sun J, Hao K, Yao W, Zhang D. Associations of dietary ?-3, ?-6 fatty acids consumption with sleep disorders and sleep duration among adults. Nutrients 2021;13(5):1475.
Cui J, Li L, Ren L, Sun J, Zhao H, Sun Y. Dietary n-3 and n-6 fatty acid intakes and NAFLD: A cross-sectional study in the United States. Asia Pac J Clin Nutr 2021;30(1):87-98.
Grytten E, Laupsa-Borge J, Bohov P, et al. Changes in lipoprotein particle subclasses, standard lipids, and apolipoproteins after supplementation with n-3 or n-6 PUFAs in abdominal obesity: A randomized double-blind crossover study. Clin Nutr 2021;40(5):2556-2575.
Lemoine C, Brigham E, Woo H, et al. Relationship between omega-3 and omega-6 fatty acid intake and chronic obstructive pulmonary disease morbidity. Ann Am Thorac Soc. 2020;17(3):378-381.
Hanson S, Thorpe G, Winstanley L, Abdelhamid AS, Hooper L; PUFAH group. Omega-3, omega-6 and total dietary polyunsaturated fat on cancer incidence: systematic review and meta-analysis of randomised trials. Br J Cancer. 2020;122(8):1260-1270.
Kim Y, Kim J. N-6 polyunsaturated fatty acids and risk of cancer: Accumulating evidence from prospective studies. Nutrients. 2020;12(9):2523.
Farinotti M, Vacchi L, Simi S, Di Pietrantonj C, Brait L, Filippini G. Dietary interventions for multiple sclerosis. Cochrane Database Syst Rev. 2012 Dec 12;12:CD004192. 2020 May 19;5:CD004192.
Select a condition to view a list of vitamins
CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
This copyrighted material is licensed from Therapeutic Research Center, LLC. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
Licensed from Therapeutic Research Center, LLC
Copyright © 1995-2025 by Therapeutic Research Center, LLC. All Rights Reserved.