PERIWINKLE: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Periwinkle is an herb. The parts that grow above the ground are used to make medicine. Don't confuse periwinkle with Madagascar periwinkle (Catharanthus roseus).

Despite serious safety concerns, people use periwinkle for memory and thinking, diarrhea, vaginal discharge, sore throat, and toothache, but there is no good scientific evidence to support these uses.

How does it work ?

Periwinkle can lower blood pressure. It can also help reduce swelling (inflammation) and have a drying (astringent) effect on the tissues.

Uses & Effectiveness

Insufficient Evidence for

Tonsillitis.
Sore throat.
Intestinal swelling (inflammation).
Toothache.
Chest pain.
Wounds.
High blood pressure.
Other conditions.

More evidence is needed to rate the effectiveness of periwinkle for these uses.

Side Effects

Special Precautions and Warnings

When taken by mouth: Periwinkle is UNSAFE. It can cause side effects such as nausea, vomiting, and other stomach and intestinal symptoms. It can also cause nerve, kidney, and liver damage. Large amounts can cause very low blood pressure. Periwinkle is UNSAFE for anyone to use, but people with certain conditions are especially at risk for harmful side effects.

Pregnancy and breast-feeding: Periwinkle is UNSAFE. Don't use it.

Constipation: Periwinkle has a drying effect on tissues. This means it can make constipation worse. Don't use it.

Low blood pressure: Periwinkle can lower blood pressure. If you already have low blood pressure, using periwinkle can make it drop too low. Don't use it.

Surgery: Periwinkle can lower blood pressure. There is a concern that it might interfere with blood pressure control during and after surgery. Stop using periwinkle at least 2 weeks before a scheduled surgery.

Interactions

Moderate Interaction

Be cautious with this combination

Medications for high blood pressure (Antihypertensive drugs) interacts with PERIWINKLE
Periwinkle seems to decrease blood pressure. Taking periwinkle along with medications for high blood pressure might cause your blood pressure to go too low.

Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.

Dosing

The appropriate dose of periwinkle depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for periwinkle. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

Bagchi D, Bagchi M, Stohs SJ, et al. Cellular protection with proanthocyanidins derived from grape seeds. Ann N Y Acad Sci 2002;957:260-70.

Barona J, Aristizabal JC, Blesso CN, et al. Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome. J Nutr 2012;142:1626-32. View abstract.

Bernstein DI, Bernstein CK, Deng C, et al. Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study. Ann Allergy Asthma Immunol 2002;88:272-8.. View abstract.

Berry AC, Nakshabendi R, Abidali H, et al. Adverse effects of grape seed extract supplement: A clinical case and long-term follow-up. J Diet Suppl. 2016;13(2):232-5. View abstract.

BIBRA working group. Anthocyanins. Toxicity profile. BIBRA Toxicol Int 1991;6.

Bombardelli E, Morazzoni P. Vitis vinifera L. Fitoterapia 1995;LXVI:291-317.

Calapai G, Bonina F, Bonina A, et al. A randomized, double-blinded, clinical trial on effects of a Vitis vinifera extract on cognitive function in healthy older adults. Front Pharmacol. 2017;8:776. View abstract.

Chen WT, Yang TS, Chen HC, et al. Effectiveness of a novel herbal agent MB-6 as a potential adjunct to 5-fluoracil-based chemotherapy in colorectal cancer. Nutr Res. 2014;34(7):585-94. View abstract.

Chevallier A. The Encyclopedia of Medicinal Plants. London, UK: Dorling Kindersley, Ltd., 1996.

Chisholm A, Mann J, Skeaff M, et al. A diet rich in walnuts favourably influences plasma fatty acid profile in moderately hyperlipidaemic subjects. Eur J Clin Nutr 1998;52:12-6. View abstract.

Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.

Derosa G, D'Angelo A, Preti PS, Maffioli P. Evaluation of the Effect on Sexual Performance of a Nutraceutical Combination Containing Alpha Lipoic Acid, Vitis vinifera L. and Ginkgo biloba, Compared to Placebo, Avanafil or a Combination of Nutraceutical Plus Avanafil in Males With Type 2 Diabetes Mellitus With Erectile Dysfunction. Front Endocrinol (Lausanne) 2022;13:847240. View abstract.

Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182

Eyi, E. G., Engin-Ustun, Y., Kaba, M., and Mollamahmutoglu, L. Ankaferd blood stopper in episiotomy repair. Clin Exp Obstet Gynecol 2013;40(1):141-143. View abstract.

Foshati S, Nouripour F, Sadeghi E, Amani R. The effect of grape (Vitis vinifera) seed extract supplementation on flow-mediated dilation, blood pressure, and heart rate: A systematic review and meta-analysis of controlled trials with duration- and dose-response analysis. Pharmacol Res 2022;175:105905. View abstract.

Freedman JE, Parker C, Li L, et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 2001;103:2792-8.. View abstract.

Ghaedi E , Moradi S , Aslani Z , Kord-Varkaneh H , Miraghajani M , Mohammadi H . Effects of grape products on blood lipids: a systematic review and dose-response meta-analysis of randomized controlled trials. Food Funct. 2019;10(10):6399-6416. View abstract.

Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. View abstract.

Gupta H, Pawar D, Riva A, et al. A randomized, double-blind, placebo-controlled trial to evaluate efficacy and tolerability of an optimized botanical combination in the management of patients with primary hypercholesterolemia and mixed dyslipidemia. Phytother Res 2012;26:265-272. View abstract.

Han HJ, Jung UJ, Kim HJ, et al. Combined supplementation with grape pomace and omija fruit ethanol extracts dose-dependently improves body composition, plasma lipid profiles, inflammatory status, and antioxidant capacity in overweight and obese subjects. J Med Food. 2016;19(2):170-80. View abstract.

Hemmati AA, Foroozan M, Houshmand G, et al. The topical effect of grape seed extract 2% cream on surgery wound healing. Glob J Health Sci 2014;7(3):52-8. View abstract.

Ahn, Y. S., Byrnes, J. J., Harrington, W. J., Cayer, M. L., Smith, D. S., Brunskill, D. E., and Pall, L. M. The treatment of idiopathic thrombocytopenia with vinblastine-loaded platelets. N.Engl.J.Med. 5-18-1978;298(20):1101-1107. View abstract.

Barnett, C. J., Cullinan, G. J., Gerzon, K., Hoying, R. C., Jones, W. E., Newlon, W. M., Poore, G. A., Robison, R. L., Sweeney, M. J., Todd, G. C., Dyke, R. W., and Nelson, R. L. Structure-activity relationships of dimeric Catharanthus alkaloids. 1. Deacetylvinblastine amide (vindesine) sulfate. J.Med.Chem. 1978;21(1):88-96. View abstract.

Bolcskei, H., Szantay, C., Jr., Mak, M., Balazs, M., and Szantay, C. [New antitumor derivatives of vinblastine]. Acta Pharm.Hung. 1998;68(2):87-93. View abstract.

Cardinali, G. [Place of Vinca rosea alkaloids (Catharanthus roseus) in the treatment of Hodgkin's disease]. Haematologica 1973;53(1):51-64. View abstract.

Chamouni, P., Lenain, P., Buchonnet, G., Merle, V., Bourgain, C., Boyer, A., Girault, C., and Czernichow, P. Difficulties in the management of an incomplete form of refractory thrombotic thrombocytopenic purpura, the usefulness of vincristine. Transfus.Sci. 2000;23(2):101-106. View abstract.

Dekoninck, W. J., Jocquet, P., Jacquy, J., and Henriet, M. Comparative study of the clinical effects of vincamine + glycerol versus glycerol + placebo in the acute phase of stroke. Arzneimittelforschung. 1978;28(9):1654-1657. View abstract.

Ena, J., Garcia, A., and de Mar, Masia M. Vincristine as therapy for idiopathic thrombocytopenic purpura in patients infected with human immunodeficiency virus. Clin.Infect.Dis. 1996;22(5):880-881. View abstract.

Fenaux, P., Quiquandon, I., Caulier, M. T., Simon, M., Walter, M. P., and Bauters, F. Slow infusions of vinblastine in the treatment of adult idiopathic thrombocytopenic purpura: a report on 43 cases. Blut 1990;60(4):238-241. View abstract.

Fischhof, P. K., Moslinger-Gehmayr, R., Herrmann, W. M., Friedmann, A., and Russmann, D. L. Therapeutic efficacy of vincamine in dementia. Neuropsychobiology 1996;34(1):29-35. View abstract.

Gross, Z., Rodriguez, J. J., and Stalnaker, B. L. Vincristine for refractory autoimmune thrombocytopenic purpura in pregnancy. A case report. J.Reprod.Med. 1995;40(10):739-742. View abstract.

Hirsh, V., Desjardins, P., Needles, B. M., Rigas, J. R., Jahanzeb, M., Nguyen, L., Zembryki, D., and Leopold, L. H. Oral versus intravenous administration of vinorelbine as a single agent for the first-line treatment of metastatic nonsmall cell lung carcinoma (NSCLC): A randomized phase II trial. Am.J.Clin.Oncol. 2007;30(3):245-251. View abstract.

Jacquillat, C. and Weil, M. [Periwinkle alkaloids. Treatment of Hodgkin's disease and leukemia]. Sem.Ther. 1964;40(6):395-400. View abstract.

Karpati, E., Biro, K., and Kukorelli, T. [Investigation of vasoactive agents with indole skeletons at Richter Ltd.]. Acta Pharm.Hung. 2002;72(1):25-36. View abstract.

Krainer, M., Tomek, S., Elandt, K., Horak, P., Albrecht, W., Eisenmenger, M., Holtl, W., Schramek, P., Stackl, W., Zielinski, C., and Reibenwein, J. A prospective, open label, randomized phase II trial of weekly docetaxel versus weekly vinorelbine as first line chemotherapy in patients with androgen independent prostate cancer. J.Urol. 2007;177(6):2141-2145. View abstract.

Mans, D. R., da Rocha, A. B., and Schwartsmann, G. Anti-cancer drug discovery and development in Brazil: targeted plant collection as a rational strategy to acquire candidate anti-cancer compounds. Oncologist. 2000;5(3):185-198. View abstract.

Mukhopadhyay, S., El-Sayed, A., Handy, G. A., and Cordell, G. A. Catharanthus alkaloids XXXVII. 16-Epi-Z-isositsirikine, a monomeric indole alkaloid with antineoplastic activity from Catharanthus roseus and Rhazya stricta. J.Nat.Prod. 1983;46(3):409-413. View abstract.

Nakabayashi, M., Ling, J., Xie, W., Regan, M. M., and Oh, W. K. Response to vinorelbine with or without estramustine as second-line chemotherapy in patients with hormone-refractory prostate cancer. Cancer J. 2007;13(2):125-129. View abstract.

Ng, R., Hasan, B., Mittmann, N., Florescu, M., Shepherd, F. A., Ding, K., Butts, C. A., Cormier, Y., Darling, G., Goss, G. D., Inculet, R., Seymour, L., Winton, T. L., Evans, W. K., and Leighl, N. B. Economic analysis of NCIC CTG JBR.10: a randomized trial of adjuvant vinorelbine plus cisplatin compared with observation in early stage non-small-cell lung cancer--a report of the Working Group on Economic Analysis, and the Lung Disease Site Group, National Cancer Institute of Canada Clinical Trials Group. J.Clin.Oncol. 6-1-2007;25(16):2256-2261. View abstract.

Nishii, K., Sakakura, M., Tsukada, T., Ryuu, H., and Katayama, N. Successful treatment with imatinib combined with less intensive chemotherapy (vincristine and dexamethasone) as induction therapy in a very elderly patient with Philadelphia chromosome-positive acute lymphoblastic leukemia. Int.J.Hematol. 2007;85(3):273-274. View abstract.

Nomura, T., Maekawa, T., Uchino, H., Miyazaki, T., Miura, Y., Abe, T., Asano, S., Kuriya, S., Nagai, K., Yawata, Y., and . Clinical usefulness of vinca alkaloid slow infusion in the treatment of chronic refractory idiopathic thrombocytopenic purpura: a multicenter cooperative study. Nippon Ketsueki Gakkai Zasshi 1990;53(1):98-104. View abstract.

Pepe, C., Hasan, B., Winton, T. L., Seymour, L., Graham, B., Livingston, R. B., Johnson, D. H., Rigas, J. R., Ding, K., and Shepherd, F. A. Adjuvant vinorelbine and cisplatin in elderly patients: National Cancer Institute of Canada and Intergroup Study JBR.10. J.Clin.Oncol. 4-20-2007;25(12):1553-1561. View abstract.

Rahmani, R. and Zhou, X. J. Pharmacokinetics and metabolism of vinca alkaloids. Cancer Surv. 1993;17:269-281. View abstract.

Schiavotto, C., Castaman, G., and Rodeghiero, F. Treatment of idiopathic thrombocytopenic purpura (ITP) in patients with refractoriness to or with contraindication for corticosteroids and/or splenectomy with immunosuppressive therapy and danazol. Haematologica 1993;78(6 Suppl 2):29-34. View abstract.

Sikorska, A., Slomkowski, M., Marlanka, K., Konopka, L., and Gorski, T. The use of vinca alkaloids in adult patients with refractory chronic idiopathic thrombocytopenia. Clin.Lab Haematol. 2004;26(6):407-411. View abstract.

Ueda, J. Y., Tezuka, Y., Banskota, A. H., Le, Tran Q., Tran, Q. K., Harimaya, Y., Saiki, I., and Kadota, S. Antiproliferative activity of Vietnamese medicinal plants. Biol.Pharm.Bull. 2002;25(6):753-760. View abstract.

Verma, S., Wong, N. S., Trudeau, M., Joy, A., Mackey, J., Dranitsaris, G., and Clemons, M. Survival differences observed in metastatic breast cancer patients treated with capecitabine when compared with vinorelbine after pretreatment with anthracycline and taxane. Am.J.Clin.Oncol. 2007;30(3):297-302. View abstract.

Wautier, J. L., Boizard, B., and Caen, J. P. [Transfusion of platelets loaded with periwinkle alkaloids as a treatment for chronic idiopathic thrombocytopenic purpura (author's transl)]. Nouv.Presse Med. 1-20-1979;8(3):185-188. View abstract.

Agri Res Svc: Dr. Duke's phytochemical and ethnobotanical databases. www.ars-grin.gov/duke (Accessed 3 November 1999).

Kidd PM. A review of nutrients and botanicals in the integrative management of cognitive dysfunction. Altern Med Rev 1999;4:144-61.. View abstract.

The Natural Pharmacist. Vinpocetine. www.tnp.com/substance.asp?ID=573. (Accessed 16 December 1999).

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