BLACK MULBERRY: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Black mulberry (Morus nigra) is a plant found worldwide. The ripe berry, twigs, and root bark are used to make medicine. The ripe berry is also eaten.

Black mulberry fruit contains pectin, which might act as a laxative. Chemicals in black mulberry fruit and black mulberry twigs might have blood sugar lowering effects.

People use black mulberry for constipation, symptoms of menopause, runny nose, and many other conditions, but there is no good scientific evidence to support these uses.

Don't confuse black mulberry with white mulberry. These are not the same.

Uses & Effectiveness

We currently have no information for BLACK MULBERRY overview.

Side Effects

When taken by mouth: Black mulberry fruit and the molasses made from the fruit is possibly safe when eaten as a food. The fruit is commonly used in foods, but there isn't enough reliable information to know if it is safe to use as a medicine. Black mulberry leaf is possibly safe when taken as a medicine, short-term. Black mulberry leaf powder has been used safely for up to 60 days.

Special Precautions and Warnings

Pregnancy and breast-feeding: There isn't enough reliable information to know if black mulberry is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Allergies: People who are allergic to fig might also be allergic to black mulberry.

Surgery: Black mulberry seems to lower blood sugar levels. It might interfere with blood sugar control during and after surgery. Stop using black mulberry at least 2 weeks before a scheduled surgery.

Interactions

Moderate Interaction

Be cautious with this combination

Medications for diabetes (Antidiabetes drugs) interacts with BLACK MULBERRY
Black mulberry leaf might lower blood sugar levels. Taking black mulberry leaf along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Midazolam (Versed) interacts with BLACK MULBERRY
The body breaks down midazolam to get rid of it. Black mulberry might slow the breakdown of midazolam. This might increase the effects and side effects of midazolam.

Dosing

There isn't enough reliable information to know what an appropriate dose of black mulberry might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

View References

REFERENCES:

Caiaffa, M. F., Cataldo, V. M., Tursi, A., and Macchia, L. Fig and mulberry cross-allergy. Ann.Allergy Asthma Immunol. 2003;91(5):493-495. View abstract.

de Souza, M. M., Bittar, M., Cechinel-Filho, V., Yunes, R. A., Messana, I., Delle, Monache F., and Ferrari, F. Antinociceptive properties of morusin, a prenylflavonoid isolated from Morus nigra root bark. Z Naturforsch.[C.] 2000;55(3-4):256-260. View abstract.

Kim, H., Yoon, Y. J., Shon, J. H., Cha, I. J., Shin, J. G., and Liu, K. H. Inhibitory effects of fruit juices on CYP3A activity. Drug Metab Dispos. 2006;34(4):521-523. View abstract.

Muntean, D., Imre, S., Avrigeanu, V., and Csedo, C. Physico-chemical study of the isolated flavonoids from leaves and bark of Morus alba L. and Morus nigra L. species. Farmacia 2002;50:97-103.

Costa JPL, Brito HO, Galvão-Moreira LV, Brito LGO, Costa-Paiva L, Brito LMO. Randomized double-blind placebo-controlled trial of the effect of Morus nigra L. (black mulberry) leaf powder on symptoms and quality of life among climacteric women. Int J Gynaecol Obstet 2020;148(2):243-52. View abstract.

Demir Dogan M, Can G, Meral R. Effectiveness of black mulberry molasses in prevention of radiotherapy-induced oral mucositis: A randomized controlled study in head and neck cancer patients. J Altern Complement Med. 2017;23(12):971-979. View abstract.

Imran M, Khan H, Shah M, Khan R, Khan F. Chemical composition and antioxidant activity of certain Morus species. J Zhejiang Univ Sci B. 2010;11(12):973-80. View abstract.

Karabey T, Karagözogli S, Aygün N, Sümer Z. The Effect of Oral Care With Black Mulberry Extract on Oral Mucositis, Dry Mouth, and Weight Gain in Patients With Cancer. Clin J Oncol Nurs 2022;26(6):636-642. View abstract.

Korkut S, Karadag S, Levent Çinar S. The effect of oral care with black mulberry syrup on oral mucositis in patients with COPD: a mixed study. Altern Ther Health Med 2021. View abstract.

Momeni H, Salehi A, Absalan A, Akbari M. Hydro-alcoholic extract of Morus nigra reduces fasting blood glucose and HbA1c% in diabetic patients, probably via competitive and allosteric interaction with alpha-glucosidase enzyme; a clinical trial and in silico analysis. J Complement Integr Med 2021. View abstract.

Navarro-Triviño FJ, Jadczak P, Llamas-Molina JM, Ruiz-Villaverde R. Lichenoid contact dermatitis caused by Morus nigra L. Contact Dermatitis 2021;84(6):484-486. View abstract.

Xu LJ, Yu MH, Huang CY, et al. Isoprenylated flavonoids from Morus nigra and their PPAR ? agonistic activities. Fitoterapia 2018;127:109-14. View abstract.

Yazdankhah S, Hojjati M, Azizi MH. The antidiabetic potential of black mulberry extract-enriched pasta through inhibition of enzymes and glycemic index. Plant Foods Hum Nutr 2019;74(1):149-55. View abstract.

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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