Overview

Pyruvate is a three-carbon acid that is naturally formed during glycolysis, the process in which the body breaks down sugar (glucose).

Pyruvate might increase the breakdown of fat, which could improve weight loss. Pyruvic acid seems to cause the outer layer of skin cells to slough off, which might benefit some skin conditions.

People use pyruvate for obesity, acne, high cholesterol, cataracts, athletic performance, and many other conditions, but there is no good scientific evidence to support most of these uses.

Uses & Effectiveness

Possibly Effective for

  • Acne. Applying a pyruvic acid skin peel might improve acne in some people.
  • Obesity. Taking pyruvate by mouth while dieting and exercising might improve weight loss by a small amount in people who are overweight and obese.

There is interest in using pyruvate for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Pyruvate is possibly safe when used appropriately for up to six weeks. Side effects such as stomach upset, gas, bloating, and diarrhea might occur when used in doses above 30 grams daily.

When applied to the skin: Facial peels containing up to 50% pyruvic acid are possibly safe when applied by a healthcare professional. Severe skin burning might occur. It should only be applied to small patches of skin at a time.

When inhaled: Pyruvate is possibly safe when used in a nebulizer for up to six weeks.

Special Precautions and Warnings

When taken by mouth: Pyruvate is possibly safe when used appropriately for up to six weeks. Side effects such as stomach upset, gas, bloating, and diarrhea might occur when used in doses above 30 grams daily.

When applied to the skin: Facial peels containing up to 50% pyruvic acid are possibly safe when applied by a healthcare professional. Severe skin burning might occur. It should only be applied to small patches of skin at a time.

When inhaled: Pyruvate is possibly safe when used in a nebulizer for up to six weeks.

Pregnancy and breast-feeding: There isn't enough reliable information to know if pyruvate is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Irritable bowel syndrome (IBS): Taking high amounts of pyruvate, such as 30 grams daily or more, might cause diarrhea, loose stools, and bloating.

Interactions

We currently have no information for Pyruvate overview.

Dosing

Pyruvate has most often been used by adults in doses of 6-40 grams by mouth daily for up to 6 weeks. It's also been used in topical products such as facial skin peels and creams. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.
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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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