Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Choi HK, Jung GW, Moon KH, et al. Clinical study of SS-Cream in patients with lifelong premature ejaculation. Urology 2000;55:257-61.
Agricultural Research Service. Dr. Duke's Phytochemical and Ethnobotanical Databases. Available at: www.ars-grin.gov/duke/.
Blumenthal M, Goldberg A, Brinckmann J, eds. Herbal Medicine Expanded Commission E Monographs. Newton, MA: Integrative Medicine Communications, 2000.
Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
Anderson RA, Broadhurst CL, Polansky MM, et al. Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like Biological Activity. J Agric Food Chem 2004;52:65-70.
Jarvill-Taylor KJ, Anderson RA, Graves DJ. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr 2001;20:327-36.
Khan A, Safdar M, Ali Khan M, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26:3215-8.
Onderoglu S, Sozer S, Erbil KM, et al. The evaluation of long-term effcts of cinnamon bark and olive leaf on toxicity induced by streptozotocin administration to rats. J Pharm Pharmacol 1999;51:1305-12.
Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35:157-62.
Pilapil VR. Toxic manifestations of cinnamon oil ingestion in a child. Clin Pediatr (Phila) 1989;28:276..
Rosti L, Gastaldi G. Chronic salmonellosis and cinnamon. Pediatrics 2005;116:1057.
Verspohl EJ, Bauer K, Neddermann E. Antidiabetic effect of Cinnamomum cassia and Cinnamomum zeylanicum in vivo and in vitro. Phytother Res 2005;19:203-6.
Felter SP, Vassallo JD, Carlton BD, Daston GP. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food Chem Toxicol 2006;44:462-75.
Quale, J. M., Landman, D., Zaman, M. M., Burney, S., and Sathe, S. S. In vitro activity of Cinnamomum zeylanicum against azole resistant and sensitive Candida species and a pilot study of cinnamon for oral candidiasis. Am J Chin Med 1996;24(2):103-109.
Corren, J., Lemay, M., Lin, Y., Rozga, L., and Randolph, R. K. Clinical and biochemical effects of a combination botanical product (ClearGuard) for allergy: a pilot randomized double-blind placebo-controlled trial. Nutr.J 2008;7:20.
Hawrelak, J. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. J Altern Complement Med 2010;16(10):1065-1071.
Sambaiah, K. and Srinivasan, K. Effect of cumin, cinnamon, ginger, mustard and tamarind in induced hypercholesterolemic rats. Nahrung 1991;35(1):47-51.
Ranasinghe P, Jayawardena R, Galappaththy P, et al. Response to Akilen et al. Efficacy and safety of 'true' cinnamon (Cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta-analysis. Diabet Med 2013 Apr;30(4):506-7.
Jain S, Sangma T, Shukla SK, Mediratta PK. Effect of Cinnamomum zeylanicum extract on scopolamine-induced cognitive impairment and oxidative stress in rats. Nutr Neurosci 2015;18(5):210-6.
Meades G Jr, Henken RL, Waldrop GL, et al. Constituents of cinnamon inhibit bacterial acetyl CoA carboxylase. Planta Med 2010;76(14):1570-5.
Oliveira JdA, da Silva IC, Trindade LA, et al. Safety and tolerability of essential oil from Cinnamomum zeylanicum blume leaves with action on oral candidosis and its effect on the physical properties of the acylic resin. Evid Based Complement Alternat Med 2014;2014:325670.
Ranasinghe P, Pigera S, Premakumara GA, et al. Medicinal properties of 'true' cinnamon (Cinnamomum zeylanicum): a systematic review. BMC Complement Altern Med 2013;13:275.
Ranasinghe P, Galappaththy P. Health benefits of Ceylon cinnamon (Cinnamomum zeylanicum): a summary of the current evidence. Ceylon Med J 2016;61(1):1-5.
Rana IS, Singh A, Gwal R. In vitro study of antibacterial activity of aromatic and medicinal plants essential oils with special reference to cinnamon oil. Int J Pharm Pharm Sci 2011;3:376-80.
Ranasinghe P, Jayawardana R, Galappaththy P, et al. Efficacy and safety of 'true' cinnamon (Cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta-analysis. Diabet Med 2012;29(12):1480-92.
Rosti L, Gastaldi G, Frigiola A. Cinnamon and bacterial enteric infections. Indian J Pediatr 2008;75(5).
El Az NMTA, Khalil FAM, Shaapan RM. Therapeutic effect of onion (allium cepa) and cinnamon (cinnamomum zeylanicum) oils on cryptosporidiosis in experimentally infected mice. Global Vet 2011;7:179-83.
Concalves JL, Lopes RC, Oliveira DB, et al. In vitro anti-rotavirus activity of some medicinal plants used in Brazil against diarrhea. J Ethnopharmacol 2005;99(3):403-7.
Tsuji-Naito K. Aldehydic components of cinnamon bark extract suppresses RANKL-induced osteoclastogenesis through NFATc1 downregulation. Bioorg Med Chem 2008;16(20):9176-83.
Nyadjeu P, Dongmo A, Nguelefack TB, Kamanyi A. Antihypertensive and vasorelaxant effects of Cinnamomum zeylanicum stem bark aqueous extracts. J Complement Integr Med 2011;8.
Wansi SL, Nyadjeu P, Ngamga D, et al. Blood pressure lowering effect of the ethanol extract from the stembark of Cinnamomum zeylanicum (lauraceae) in rats. Pharmacol online 2007;3:166-76.
Hassan SA, Barthwal R, Nair MS, Haque SS. Aqueous bark extract of Cinnamomum zeylanicum: a potential therapeutic agent for steptozotocin-induced type 1 diabetes mellitus (T1DM) rats. Top J Pharm Res 2012;11:429-35.
Javed I, Faisal I, Rahman Z, et al. Lipid lowering effect of Cinnamomum zeylanicum in hyperlipidaemic albino rabbits. Pak J Pharm Sci 2012;25(1):141-7.
Chularisi MU, Picha P, Rienkijkan M, Preechanukool K. The cytotoxic effect of petroleum ether and chloroform extracts from Ceylon cinnamon (Cinnamomum zeylanicum nees) barks on tumor cells in vitro. Int J Crude Drug Res 1984;22:177-80.
Singh R, Koppikar SJ, Paul P, et al. Comparative analysis of cytotoxic effect of aqueous cinnamon extract from Cinnamomum zeylanicum bark with commercial cinnamaldehyde on various cell lines. Pharm Biol 2009;47:1174-9.
Takasao N, Tsuji-Naito K, Ishikura S, et al. Cinnamon extract promotes type I collagen biosynthesis via activation of IGF-I signaling in human dermal fibroblasts. J Agric Food Chem 2012;60(5):1193-200.
Alqasoumi S. Anti-secretagogue and antiulcer effects of 'cinnamon' Cinnamomum zeylanicum in rats. J Pharmacog Phytother 2012;4:53-61.
Rao HJ, Lakshmi. Anti-diarrhoeal activity of the aqueous extract of the bark of Cinnamomum zeylanicum linn in mice. J Clin Diagn Res 2012;6:117-24.
Eidi A, Mortazavi P, Bazargam M, Zaringhalam J. Hepatoprotective activity of cinnamon ethanolic extract against CCL 4-induced liver injury in rats. EXCLI J 2012;11:495-507.
Samarasekera R, Kalhari KS, Weerasinghe IS. Mosquitocidal acitivy of leaf and bark essential oils of Ceylon cinnamomum zeylanicum. J Essent Oil Res 2005;17:301-3.
Yang YC, Lee HS, Lee SE, et al. Ovicidal and adulticidal activities of Cinnamomum zeylanicum bark essential oil compounds and related compounds against Pediculus humanus capitis (Anopluar: Pediculicidae). Int J Parasitol 2005;35(14):1595-600.
Peterson DW, George RC, Scaramozzino F, et al. Cinnamon extract inhibits tau aggregation associated with Alzheimer's disease in vitro. J Alzheimers Dis 2009;17(3):585-97.
Farahpour MR, Habibi M. Evaluation of the wound healing activity of an ethanolic extract of Ceylon cinnamon in mice. Vet Med 2012;57:53-7.
Kamath JV, Rana AC, Chowdhury AR. Pro-healing effect of Cinnamomum zeylanicum bark. Phytother Res 2003;17(8):970-2.
Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43.
Azimi P, Ghiasvand R, Feizi A, et al. Effect of cinnamon, cardamom, saffron and ginger consumption on blood pressure and a marker of endothelial function in patients with type 2 diabetes mellitus: A randomized controlled clinical trial. Blood Press. 2016;25(3):133-40.
Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21.
Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189.
Arentz S, Smith CA, Abbott J, Fahey P, Cheema BS, Bensoussan A. Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial. Phytother Res. 2017 Sep;31(9):1330-1340.
Hajimonfarednejad M, Nimrouzi M, Heydari M, Zarshenas MM, Raee MJ, Jahromi BN. Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome: a randomized double-blind placebo controlled clinical trial. Phytother Res 2018;32(2):276-83.
Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4.
Ranasinghe P, Jayawardena R, Pigera S, et al. Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial. BMC Complement Altern Med 2017;17(1):550.
Azimi P, Ghiasvand R Feizi A, Hariri M, Abbasi B. Effects of cinnamon, cardamom, saffron, and ginger consumption on markers of glycemic control, lipid profile, oxidative stress, and inflammation in type 2 diabetes. Rev Diabet Stud. 2014 Fall-Winter;11(3-4):258-66.
Mirfeizi M, Mehdizadeh Tourzani Z, Mirfeizi SZ, et al. Controlling type 2 diabetes mellitus with herbal medicines: a triple-blind randomized clinical trial of efficacy and safety. J Diabetes. 2016 Sep;8(5):647-56.
Talaei B, Amouzegar A, Sahranavard S, Hedayati M, Mirmiran P, Azizi F. Effects of cinnamon consumption on glycemic indicators, advanced glycation end products, and antioxidant status in type 2 diabetic patients. Nutrients. 2017 Sep 8;9(9). Pii:E991.
Vafa M, Mohammadi F, Shidfar F, Sormaghi MS, Heidari I, Golestan B, Armiri F. Effects of cinnamon consumption on glycemic status, lipid profile and body composition in type 2 diabetic patients. Int J Prev Med. 2012 Aug;3(8):531-6.
Vallianou N, Tsang C, Taghizadeh M, Davoodvandi A, Jafarnejad S. Effect of cinnamon (Cinnamomum zeylanicum) supplementation on serum C-reactive protein concentrations: a meta-analysis and systematic review. Complement Ther Med 2019;42:271-8.
Jahangirifar M, Taebi M, Dolatian M. The effect of cinnamon on primary dysmenorrhea: a randomized, double-blind clinical trial. Complement Ther Clin Pract 2018;33:56-60.
Ainehchi N, Khaki A, Farshbaf-Khalili A, Hammadeh M, Ouladsahebmadarek E. The Effectiveness of Herbal Mixture Supplements with and without Clomiphene Citrate in Comparison to Clomiphene Citrate on Serum Antioxidants and Glycemic Biomarkers in Women with Polycystic Ovary Syndrome Willing to be Pregnant: A Randomized Clinical Trial. Biomolecules. 2019;9(6):215.
Steels E, Steels E, Deshpande P, Thakurdesai P, Dighe S, Collet T. A randomized, double-blind placebo-controlled study of intranasal standardized cinnamon bark extract for seasonal allergic rhinitis. Complement Ther Med. 2019;47:102198.
Heshmati J, Sepidarkish M, Morvaridzadeh M, et al. The effect of cinnamon supplementation on glycemic control in women with polycystic ovary syndrome: A systematic review and meta-analysis. J Food Biochem 2020 Oct 27:e13543. doi: 10.1111/jfbc.13543.
Mirmiranpour H, Huseini HF, Derakhshanian H, Khodaii Z, Tavakoli-Far B. Effects of probiotic, cinnamon, and synbiotic supplementation on glycemic control and antioxidant status in people with type 2 diabetes; a randomized, double-blind, placebo-controlled study. J Diabetes Metab Disord 2019;19(1):53-60.
Zareie A, Sahebkar A, Khorvash F, Bagherniya M, Hasanzadeh A, Askari G. Effect of cinnamon on migraine attacks and inflammatory markers: A randomized double-blind placebo-controlled trial. Phytother Res 2020;34(11):2945-52.
De Silva DAM, Jeewanthi RKC, Rajapaksha RHN, et al. Clean vs dirty labels: Transparency and authenticity of the labels of Ceylon cinnamon. PLoS One 2021;16(11):e0260474.
Shirzad F, Morovatdar N, Rezaee R, Tsarouhas K, Abdollahi Moghadam A. Cinnamon effects on blood pressure and metabolic profile: A double-blind, randomized, placebo-controlled trial in patients with stage 1 hypertension. Avicenna J Phytomed 2021;11(1):91-100.
de Araújo MRC, Maciel PP, Castellano LRC, et al. Efficacy of essential oil of cinnamon for the treatment of oral candidiasis: A randomized trial. Spec Care Dentist 2021;41(3):349-357.
Zobeiri M, Parvizi F, Shahpiri Z, et al. Evaluation of the effectiveness of cinnamon oil soft capsule in patients with functional dyspepsia: A randomized double-blind placebo-controlled clinical trial. Evid Based Complement Alternat Med 2021;2021:6634115.
Poursaleh Z, Choopani R, Vahedi E, Fadaei Khedmat A, Ghazvini A, Salesi M, Ghanei M. Effect of Herbal Medicine Formulation (Compound Honey Syrup) on Quality of Life in Patients With COPD: A Randomized Clinical Trial. Tanaffos. 2022 Mar;21(3):336-347.
Chase C, Doyle A, John SS, Laurent T, Griffith S. Post-operative haemorrhage secondary to cinnamon use. A case report. Int J Surg Case Rep 2022;95:107179.
Mandal A, Sharma SK, Yadav SRM, et al. Efficacy of Young Cinnamomum zeylanicum Blume Bark on Hyperglycemia and PTPase Activity in Type 2 Diabetes. Cureus 2023;15(2):e35023.
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