Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
van Joost T, Smitt JH, van Ketel WG. Sensitization to olive oil (olea europeae). Contact Dermatitis 1981;7:309-10.
Trevisan M, Krogh V, Freudenheim J, et al. Consumption of olive oil, butter, and vegetable oils and coronary heart disease risk factors. The Research Group ATS-RF2 of the Italian National Research Council. JAMA 1990;263:688-92.
Keys A, Menotti A, Karvonen MJ , et al. The diet and 15-year death rate in the seven countries study. Am J Epidemiol 1986;124:903-15.
Martin-Moreno JM, Willett WC, Gorgojo L, et al. Dietary fat, olive oil intake and breast cancer risk. Int J Cancer 1994;58:774-80.
la Vecchia C, Negri E, Franceschi S, et al. Olive oil, other dietary fats, and the risk of breast cancer (Italy). Cancer Causes Control 1995;6:545-50.
Trichopoulou A, Katsouyanni K, Stuver S, et al. Consumption of olive oil and specific food groups in relation to breast cancer risk in Greece. J Natl Cancer Inst 1995;87:110-6.
Katan MB, Zock PL, Mensink RP. Dietary oils, serum lipoproteins, and coronary heart disease. Am J Clin Nutr 1995;61:1368S-73S.
The IOOC's Trade Standard Applying to Olive Oil and Olive Pomace Oil. Available at: sovrana.com/ioocdef.htm (Accessed 23 June 2004).
Isaksson M, Bruze M. Occupational allergic contact dermatitis from olive oil in a masseur. J Am Acad Dermatol 1999;41:312-5.
Hoberman A, Paradise JL, Reynolds EA, et al. Efficacy of Auralgan for treating ear pain in children with acute otitis media. Arch Pediatr Adolesc Med 1997;151:675-8.
Mata P, Alvarez-Sala LA, Rubio MJ, et al. Effects of long-term monounsaturated- vs polyunsaturated-enriched diets on lipoproteins in healthy men and women. Am J Clin Nutr 1992;55:846-50.
Zambon A, Sartore G, Passera D, et al. Effects of hypocaloric dietary treatment enriched in oleic acid on LDL and HDL subclass distribution in mildly obese women. J Intern Med 1999;246:191-201.
Stoneham M, Goldacre M, Seagroatt V, Gill L. Olive oil, diet and colorectal cancer: an ecological study and a hypothesis. J Epidemiol Community Health 2000;54:756-60.
Linos A, Kaklamani VG, Kaklamani E, et al. Dietary factors in relation to rheumatoid arthritis: a role for olive oil and cooked vegetables? Am J Clin Nutr 1999;70:1077-82.
Ferrara LA, Raimondi AS, d'Episcopo L, et al. Olive oil and reduced need for antihypertensive medications. Arch Intern Med 2000;160:837-42.
Fernandez-Jarne E, Martinez-Losa E, Prado-Santamaria M, et al. Risk of first non-fatal myocardial infarction negatively associated with olive oil consumption: a case-control study in Spain. Int J Epidemiol 2002;31:474-80.
Togna GI, Togna AR, Franconi M, et al. Olive oil isochromans inhibit human platelet reactivity. J Nutr 2003;133:2532-6..
Brackett RE. Letter Responding to Health Claim Petition dated August 28, 2003: Monounsaturated Fatty Acids from Olive Oil and Coronary Heart Disease. CFSAN/Office of Nutritional Products, Labeling and Dietary Supplements. 2004 Nov 1; Docket No 2003Q-0559. Available at: https://www.fda.gov/ohrms/dockets/dailys/04/nov04/110404/03q-0559-ans0001-01-vol9.pdf.
Beauchamp GK, Keast RS, Morel D, et al. Phytochemistry: ibuprofen-like activity in extra-virgin olive oil. Nature 2005;437:45-6.
Aguila MB, Pinheiro AR, Mandarim-de-Lacerda CA. Spontaneously hypertensive rats left ventricular cardiomyocyte loss attenuation through different edible oils long-term intake. Int J Cardiol 2005;100:461-6.
Aguila MB, Sa Silva SP, Pinheiro AR, Mandarim-de-Lacerda CA. Effects of long-term intake of edible oils on hypertension and myocardial and aortic remodelling in spontaneously hypertensive rats. J Hypertens 2004;22:921-9.
Estruch R, Ros E, Salas-Salvado J, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013. [RETRACTED].
Williams, C. M. Beneficial nutritional properties of olive oil: implications for postprandial lipoproteins and factor VII. Nutr.Metab Cardiovasc.Dis. 2001;11(4 Suppl):51-56.
Petroni, A., Blasevich, M., Salami, M., Papini, N., Montedoro, G. F., and Galli, C. Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil. Thromb.Res. 4-15-1995;78(2):151-160.
Nagyova, A., Haban, P., Klvanova, J., and Kadrabova, J. Effects of dietary extra virgin olive oil on serum lipid resistance to oxidation and fatty acid composition in elderly lipidemic patients. Bratisl.Lek.Listy 2003;104(7-8):218-221.
Braga, C., La Vecchia, C., Franceschi, S., Negri, E., Parpinel, M., Decarli, A., Giacosa, A., and Trichopoulos, D. Olive oil, other seasoning fats, and the risk of colorectal carcinoma. Cancer 2-1-1998;82(3):448-453.
Bosetti, C., Negri, E., Franceschi, S., Talamini, R., Montella, M., Conti, E., Lagiou, P., Parazzini, F., and La Vecchia, C. Olive oil, seed oils and other added fats in relation to ovarian cancer (Italy). Cancer Causes Control 2002;13(5):465-470.
Al Waili, N. S. An alternative treatment for pityriasis versicolor, tinea cruris, tinea corporis and tinea faciei with topical application of honey, olive oil and beeswax mixture: an open pilot study. Complement Ther.Med. 2004;12(1):45-47.
Al Waili, N. S. Topical application of natural honey, beeswax and olive oil mixture for atopic dermatitis or psoriasis: partially controlled, single-blinded study. Complement Ther.Med. 2003;11(4):226-234.
Donnelly, S. M., Ali, M. A., and Churchill, D. N. Effect of n-3 fatty acids from fish oil on hemostasis, blood pressure, and lipid profile of dialysis patients. J Am Soc Nephrol 1992;2(11):1634-1639.
Rogers, S., James, K. S., Butland, B. K., Etherington, M. D., O'Brien, J. R., and Jones, J. G. Effects of a fish oil supplement on serum lipids, blood pressure, bleeding time, haemostatic and rheological variables. A double blind randomised controlled trial in healthy volunteers. Atherosclerosis 1987;63(2-3):137-143.
Buckland G, Mayén AL, Agudo A, Travier N, Navarro C, Huerta JM, Chirlaque MD, Barricarte A, Ardanaz E, Moreno-Iribas C, Marin P, Quirós JR, Redondo ML, Amiano P, Dorronsoro M, Arriola L, Molina E, Sanchez MJ, Gonzalez CA. Olive oil intake and mortality within the Spanish population (EPIC-Spain). Am J Clin Nutr. 2012 Jul;96(1):142-9.
Castro M, Romero C, de Castro A, Vargas J, Medina E, Millán R, Brenes M. Assessment of Helicobacter pylori eradication by virgin olive oil. Helicobacter. 2012 Aug;17(4):305-11.
de Bock M, Thorstensen EB, Derraik JG, Henderson HV, Hofman PL, Cutfield WS. Human absorption and metabolism of oleuropein and hydroxytyrosol ingested as olive (Olea europaea L.) leaf extract. Mol Nutr Food Res. 2013 Nov;57(11):2079-85.
Patel PV, Patel A, Kumar S, Holmes JC. Effect of subgingival application of topical ozonated olive oil in the treatment of chronic periodontitis: a randomized, controlled, double blind, clinical and microbiological study. Minerva Stomatol. 2012 Sep;61(9):381-98.
Psaltopoulou T, Kosti RI, Haidopoulos D, Dimopoulos M, Panagiotakos DB. Olive oil intake is inversely related to cancer prevalence: a systematic review and a meta-analysis of 13,800 patients and 23,340 controls in 19 observational studies. Lipids Health Dis. 2011 Jul 30;10:127.
Soltanipoor F, Delaram M, Taavoni S, Haghani H. The effect of olive oil on prevention of striae gravidarum: a randomized controlled clinical trial. Complement Ther Med. 2012 Oct;20(5):263-6.
Taavoni S, Soltanipour F, Haghani H, Ansarian H, Kheirkhah M. Effects of olive oil on striae gravidarum in the second trimester of pregnancy. Complement Ther Clin Pract. 2011 Aug;17(3):167-9.
Takeda R, Koike T, Taniguchi I, Tanaka K. Double-blind placebo-controlled trial of hydroxytyrosol of Olea europaea on pain in gonarthrosis. Phytomedicine. 2013 Jul 15;20(10):861-4.
Schwingshackl L, Lampousi AM, Portillo MP, Romaguera D, Hoffmann G, Boeing H. Olive oil in the prevention and management of type 2 diabetes mellitus: a systematic review and meta-analysis of cohort studies and intervention trials. Nutr Diabetes. 2017 Apr 10;7(4):e262.
Estruch R, Ros E, Salas-Salvadó J, et al. Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts. N Engl J Med. 2018 J;378(25):e34.
Schwartz SR, Magit AE, Rosenfeld RM, et al. Clinical Practice Guideline (Update): Earwax (Cerumen Impaction). Otolaryngol Head Neck Surg. 2017;156(1_suppl):S1-S29.
FDA completes review of qualified health claim petition for oleic acid and the risk of coronary heart disease. November 2018. Available at: www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm624758.htm. Accessed January 25, 2019.
Galvão Cândido F, Xavier Valente F, da Silva LE, et al. Consumption of extra virgin olive oil improves body composition and blood pressure in women with excess body fat: a randomized, double-blinded, placebo-controlled clinical trial. Eur J Nutr. 2018;57(7):2445-2455.
Bove A, Bellini M, Battaglia E, et al. Consensus statement AIGO/SICCR diagnosis and treatment of chronic constipation and obstructed defecation (part II: treatment). World J Gastroenterol. 2012;18(36):4994-5013.
Temple NJ, Guercio V, Tavani A. The Mediterranean Diet and Cardiovascular Disease: Gaps in the Evidence and Research Challenges. Cardiol Rev. 2019;27(3):127-130.
Rees K1, Takeda A, Martin N, et al. Mediterranean-style diet for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2019 Mar 13;3:CD009825.
Agarwal A, Ioannidis JPA. PREDIMED trial of Mediterranean diet: retracted, republished, still trusted? BMJ. 2019;364:l341.
Warrior L, Weber KM, Daubert E, et al. Olive oil intake associated with increased attention scores in women living with HIV: Findings from the Chicago Women's Interagency HIV study. Nutrients. 2019;11(8). pii: E1759.
Rezaei S, Akhlaghi M, Sasani MR, Barati Boldaji R. Olive oil lessened fatty liver severity independent of cardiometabolic correction in patients with non-alcoholic fatty liver disease: A randomized clinical trial. Nutrition. 2019;57:154-161.
Ghobadi S, Hassanzadeh-Rostami Z, Mohammadian F, et al. Comparison of blood lipid-lowering effects of olive oil and other plant oils: A systematic review and meta-analysis of 27 randomized placebo-controlled clinical trials. Crit Rev Food Sci Nutr. 2019;59(13):2110-2124.
Du ZS, Li XY, Luo HS, et al. Preoperative administration of olive oil reduces chylothorax after minimally invasive esophagectomy. Ann Thorac Surg. 2019;107(5):1540-1543.
Kouli GM, Panagiotakos DB, Kyrou I, et al. Olive oil consumption and 10-year (2002-2012) cardiovascular disease incidence: the ATTICA study. Eur J Nutr. 2019;58(1):131-138.
Karimi Z, Mousavizadeh A, Rafiei H, et al. The Effect of Using Olive Oil and Fish Oil Prophylactic Dressings on Heel Pressure Injury Development in Critically Ill Patients. Clin Cosmet Investig Dermatol. 2020 Jan 20;13:59-65.
de la Torre R, Carbó M, Pujadas M, et al. Pharmacokinetics of maslinic and oleanolic acids from olive oil - Effects on endothelial function in healthy adults. A randomized, controlled, dose-response study. Food Chem. 2020;322:126676.
Guasch-Ferré M, Liu G, Li Y, et al. Olive Oil Consumption and Cardiovascular Risk in U.S. Adults. J Am Coll Cardiol. 2020;75(15):1729-1739.
Miraj S, Pourafzali S, Ahmadabadi ZV, Rafiei Z. Effect of Olive Oil in Preventing the Development of Pressure Ulcer Grade One in Intensive Care Unit Patients. Int J Prev Med. 2020;11:23.
Panahi Y, Rastgar N, Zamani A, Sahebkar A. Comparing the Therapeutic Effects of Aloe vera and Olive Oil Combination Cream versus Topical Betamethasone for Atopic Dermatitis: A Randomized Double-blind Clinical Trial. J Pharmacopuncture. 2020;23(3):173-178.
Patti AM, Carruba G, Cicero AFG, et al. Daily Use of Extra Virgin Olive Oil with High Oleocanthal Concentration Reduced Body Weight, Waist Circumference, Alanine Transaminase, Inflammatory Cytokines and Hepatic Steatosis in Subjects with the Metabolic Syndrome: A 2-Month Intervention Study. Metabolites. 2020;10(10):392.
Santos ASEAC, Rodrigues APDS, Rosa LPS, Noll M, Silveira EA. Traditional Brazilian Diet and Olive Oil Reduce Cardiometabolic Risk Factors in Severely Obese Individuals: A Randomized Trial. Nutrients. 2020;12(5):1413.
Tsolaki M, Lazarou E, Kozori M, et al. A Randomized Clinical Trial of Greek High Phenolic Early Harvest Extra Virgin Olive Oil in Mild Cognitive Impairment: The MICOIL Pilot Study. J Alzheimers Dis. 2020;78(2):801-817.
Yilmaz Ü, Edizer S, Köse M, et al. The effect of ketogenic diet on serum lipid concentrations in children with medication resistant epilepsy. Seizure 2021;91:99-107.
Guasch-Ferré M, Li Y, Willett WC, et al. Consumption of olive oil and risk of total and cause-specific mortality among U.S. adults. J Am Coll Cardiol 2022;79(2):101-112.
Yokoi A, Kamata N. The usefulness of olive oil enema in children with severe chronic constipation. J Pediatr Surg 2021;56(7):1141-1144.
de Araújo AR, Sampaio GR, da Silva LR, et al. Effects of extra virgin olive oil and pecans on plasma fatty acids in patients with stable coronary artery disease. Nutrition 2021;91-92:111411.
Dehghani F, Morvaridzadeh M, Pizarro AB, et al. Effect of extra virgin olive oil consumption on glycemic control: A systematic review and meta-analysis. Nutr Metab Cardiovasc Dis 2021;31(7):1953-1961.
Garcia-Serrano S, Ho-Plagaro A, Santiago-Fernandez C, et al. An isolated dose of extra-virgin olive oil produces a better postprandial gut hormone response, lipidic, and anti-inflammatory profile that sunflower oil: Effect of morbid obesity. Mol Nutr Food Res 2021;65(22):e2100071.
Foshati S, Ghanizadeh A, Akhlaghi M. The effect of extra virgin olive oil on anthropometric indices, lipid profile, and markers of oxidative stress and inflammation in patients with depression, a double-blind randomised controlled trial. Int J Clin Pract 2021;75(7):e14254.
Arman-Asl H, Mohammadpour AH, Hamedi A, et al. Evaluation of the anti-constipation effects of abdominal application of olive oil ointment in children 1-4 years old: A pilot placebo-controlled, double-blind, randomized clinical trial. Adv Exp Med Biol 2021;1328:411-419.
Donat-Vargas C, Sandoval-Insausti H, Peñalvo JL, et al. Olive oil consumption is associated with a lower risk of cardiovascular disease and stroke. Clin Nutr 2022;41(1):122-130.
Markellos C, Ourailidou ME, Gavriatopoulou M, Halvatsiotis P, Sergentanis TN, Psaltopoulou T. Olive oil intake and cancer risk: A systematic review and meta-analysis. PLoS One 2022;17(1):e0261649.
Donat-Vargas C, Domínguez LJ, Sandoval-Insausti H, et al. Olive oil consumption is associated with lower frailty risk: a prospective cohort study of community-dwelling older adults. Age Ageing 2022;51(1):afab198.
Foshati S, Ghanizadeh A, Akhlaghi M. Extra-virgin olive oil improves depression symptoms without affecting salivary cortisol and brain-derived neurotrophic factor in patients with major depression: A double-blind randomized controlled trial. J Acad Nutr Diet 2022;122(2):284-297.
Taheri M, Amiri-Farahani L, Haghani S, Shokrpour M, Shojaii A. The effect of olive cream on pain and healing of caesarean section wounds: a randomised controlled clinical trial. J Wound Care 2022;31(3):244-253.
Robijns J, Becherini C, Caini S, et al. Natural and miscellaneous agents for the prevention of acute radiation dermatitis: a systematic review and meta-analysis. Support Care Cancer 2023;31(3):195.
Rodríguez-Agurto A, Bravo M, Magán-Fernandez A, et al. Randomized clinical trial on the clinical effects of a toothpaste containing extra virgin olive oil, xylitol, and betaine in gingivitis. Sci Rep 2023;13(1):6294.
Kaddoumi A, Denney TS Jr, Deshpande G, et al. Extra-Virgin Olive Oil Enhances the Blood-Brain Barrier Function in Mild Cognitive Impairment: A Randomized Controlled Trial. Nutrients 2022;14(23):5102.
Martínez-González MA, Sayón-Orea C, Bullón-Vela V, et al. Effect of olive oil consumption on cardiovascular disease, cancer, type 2 diabetes, and all-cause mortality: A systematic review and meta-analysis. Clin Nutr 2022;41(12):2659-2682.
Santos ACNA, Duarte de Souza ML, Machado AM, Kümmel Duarte C. Olive oil and body fat: a systematic review with meta-analysis. Food Funct 2023;14(12):5516-5536.
Hernández-Vásquez A, Visconti-Lopez FJ, Cabanillas-Ramirez C, et al. Efficacy and Safety of Topical Application of Olive Oil for Preventing Pressure Ulcers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Int J Environ Res Public Health 2022;19(22):14921.
Nourmohammadi M, Moradi Moghdam O, Niakan Lahiji M, Vahdat Shariatpanahi Z. High-fat low-carbohydrate enteral feeding enriched with olive oil and acute respiratory failure: A double-blind, randomized, controlled trial. Clin Nutr ESPEN 2022;52:144-150.
Abdoli A, Shahbazi R, Zoghi G, et al. The effect of topical olive oil dressing on the healing of grade 1 and 2 diabetic foot ulcers: An assessor-blind randomized controlled trial in type 2 diabetes patients. Diabetes Metab Syndr 2022;16(12):102678.
Badr LK, El Asmar R, Hakim S, et al. The efficacy of honey or olive oil on the severity of oral mucositis and pain compared to placebo (standard care) in children with leukemia receiving intensive chemotherapy: A randomized controlled trial (RCT). J Pediatr Nurs 2023;70:e48-e53.
Select a condition to view a list of vitamins
CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
This copyrighted material is licensed from Therapeutic Research Center, LLC. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
Licensed from Therapeutic Research Center, LLC
Copyright © 1995-2025 by Therapeutic Research Center, LLC. All Rights Reserved.