Cannabigerol (CBG): Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Cannabigerol is a chemical found in the Cannabis sativa plant. It does not affect thinking like some of the other chemicals in this plant.

Cannabigerol may affect certain chemicals in the body to lower cholesterol, protect the brain and nerves, and reduce swelling.

There is interest in using cannabigerol for abnormal levels of cholesterol or blood fats, Huntington disease, inflammatory bowel disease (IBD), and to stimulate appetite.

Uses & Effectiveness

We currently have no information for Cannabigerol (CBG) overview.

Side Effects

When taken by mouth: There isn't enough reliable information to know if cannabigerol is safe or what the side effects might be.

Special Precautions and Warnings

When taken by mouth: There isn't enough reliable information to know if cannabigerol is safe or what the side effects might be.

Pregnancy and breast-feeding: There isn't enough reliable information to know if cannabigerol is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Interactions

Moderate Interaction

Be cautious with this combination

Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with Cannabigerol (CBG)
Some medications are changed and broken down by the liver. Cannabigerol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with Cannabigerol (CBG)
Some medications are changed and broken down by the liver. Cannabigerol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications for high blood pressure (Antihypertensive drugs) interacts with Cannabigerol (CBG)
Cannabigerol might lower blood pressure. Taking DHA along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.

Dosing

There isn't enough reliable information to know what an appropriate dose of cannabigerol might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

View References

REFERENCES:

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Pagano E, Montanaro V, Di Girolamo A, et al. Effect of Non-psychotropic Plant-derived Cannabinoids on Bladder Contractility: Focus on Cannabigerol. Nat Prod Commun. 2015;10(6):1009-12.

Borrelli F, Fasolino I, Romano B, et al. Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease. Biochem Pharmacol. 2013;85(9):1306-16.

Borrelli F, Pagano E, Romano et al. Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid. Carcinogenesis. 2014;35(12):2787-97.

Brierley DI, Harman JR, Giallourou N, et al. Chemotherapy-induced cachexia dysregulates hypothalamic and systemic lipoamines and is attenuated by cannabigerol. J Cachexia Sarcopenia Muscle. 2019;10(4):844-859.

Brierley DI, Samuels J, Duncan M, Whalley BJ, Williams CM. A cannabigerol-rich Cannabis sativa extract, devoid of [INCREMENT]9-tetrahydrocannabinol, elicits hyperphagia in rats. Behav Pharmacol. 2017;28(4):280-284.

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Cascio MG, Gauson LA, Stevenson LA, Ross RA, Pertwee RG. Evidence that the plant cannabinoid cannabigerol is a highly potent alpha2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist. Br J Pharmacol. 2010;159(1):129-41.

D'Aniello E, Fellous T, Iannotti FA, et al. Identification and characterization of phytocannabinoids as novel dual PPARa/? agonists by a computational and in vitro experimental approach. Biochim Biophys Acta Gen Subj. 2019;1863(3):586-597.

Gugliandolo A, Pollastro F, Grassi G, Bramanti P, Mazzon E. In Vitro Model of Neuroinflammation: Efficacy of Cannabigerol, a Non-Psychoactive Cannabinoid. Int J Mol Sci. 2018;19(7). pii: E1992.

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Navarro G, Varani K, Reyes-Resina I, et al. Cannabigerol Action at Cannabinoid CB1 and CB2 Receptors and at CB1-CB2 Heteroreceptor Complexes. Front Pharmacol. 2018;9:632.

Rock EM, Goodwin JM, Limebeer CL, et al. Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews. Psychopharmacology (Berl). 2011;215(3):505-12.

Valdeolivas S, Navarrete C, Cantarero I, Bellido ML, Muñoz E, Sagredo O. Neuroprotective properties of cannabigerol in Huntington's disease: studies in R6/2 mice and 3-nitropropionate-lesioned mice. Neurotherapeutics. 2015;12(1):185-99.

Mammana S, Cavalli E, Gugliandolo A, et al. Could the Combination of Two Non-Psychotropic Cannabinoids Counteract Neuroinflammation? Effectiveness of Cannabidiol Associated with Cannabigerol. Medicina (Kaunas). 2019;55(11):747.

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Vernail VL, Bingaman SS, Silberman Y, Raup-Konsavage WM, Vrana KE, Arnold AC. Acute cannabigerol administration lowers blood pressure in mice. Front Physiol 2022;13:871962.

Sepulveda DE, Morris DP, Raup-Konsavage WM, Sun D, Vrana KE, Graziane NM. Cannabigerol (CBG) attenuates mechanical hypersensitivity elicited by chemotherapy-induced peripheral neuropathy. Eur J Pain 2022;26(9):1950-1966.

Roy P, Dennis DG, Eschbach MD, et al. Metabolites of cannabigerol generated by human cytochrome P450s are bioactive. Biochemistry 2022;61(21):2398-2408.

Aljobaily N, Krutsinger K, Viereckl MJ, et al. Low-dose administration of cannabigerol attenuates inflammation and fibrosis associated with methionine/choline deficient diet-induced NASH model via modulation of cannabinoid receptor. Nutrients 2022;15(1):178.

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Peters EN, Yardley H, Harrison A, et al. A randomized, double-blind, placebo-controlled, repeated-dose pilot study of the safety, tolerability, and preliminary effects of a cannabidiol (CBD)- and cannabigerol (CBG)-based beverage powder to support recovery from delayed onset muscle soreness (DOMS). J Int Soc Sports Nutr 2023;20(1):2280113.

Schwarz AM, Kobeci D, Mancuso JA, et al. Select Minor Cannabinoids from Cannabis sativa Are Cannabimimetic and Antinociceptive in a Mouse Model of Chronic Neuropathic Pain. J Pharmacol Exp Ther 2024;391(2):214-221.

Story G, Lee J, Cohen G, Rani A, Doherty J, Sela DA. Impact of Dietary Fat and Oral Delivery System on Cannabigerol Pharmacokinetics in Adults. Cannabis Cannabinoid Res 2024;9(6):1543-1555.

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Cannabigerol (CBG) - Uses, Side Effects, and More