Crawford M, Galli C, Visioli F, et al. Role of Plant-Derived Omega-3 Fatty Acids in Human Nutrition. Ann Nutr Metab 2000;44:263-5.
Connor WE. Alpha-linolenic acid in health and disease. Am J Clin Nutr 1999;69:827-8.
Gibson RA, Makrides M. n-3 polyunsaturated fatty acid requirements of term infants. Am J Clin Nutr 2000;71:251S-5S.
Gillingham, L. G., Gustafson, J. A., Han, S. Y., Jassal, D. S., and Jones, P. J. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr 2011;105(3):417-427.
Jones PJ, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea CE, Kris-Etherton PM. DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiovascular disease risk in the canola oil multicenter randomized controlled trial. Am J Clin Nutr. 2014 Jul;100(1):88-97.
Lin L, Allemekinders H, Dansby A, et al. Evidence of health benefits of canola oil. Nutr Rev. 2013;71(6):370-85.
Qualified Health Claims - Qualified Health Claims: Letter of Enforcement Discretion - Unsaturated Fatty Acids from Canola Oil and Reduced Risk of Coronary Heart Disease (Docket No. 2006Q-0091). 2006. Available at: https://wayback.archive-it.org/7993/20171114183734/https://www.fda.gov/Food/IngredientsPackagingLabeling/LabelingNutrition/ucm072958.htm. Accessed 25 March 2019.
https://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/. Accessed January 25, 2019.
FDA completes review of qualified health claim petition for oleic acid and the risk of coronary heart disease. November 2018. Available at: www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm624758.htm. Accessed January 25, 2019.
Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity. 2016;24(11):2261-2268.
Jones PJ, MacKay DS, Senanayake VK, et al. High-oleic canola oil consumption enriches LDL particle cholesteryl oleate content and reduces LDL proteoglycan binding in humans. Atherosclerosis. 2015;238(2):231-8.
Kruse M, von Loeffelholz C, Hoffmann D, et al. Dietary rapeseed/canola-oil supplementation reduces serum lipids and liver enzymes and alters postprandial inflammatory responses in adipose tissue compared to olive-oil supplementation in obese men. Mol Nutr Food Res. 2015;59(3):507-19.
Jenkins DJ, Kendall CW, Vuksan V, et al. Effect of lowering the glycemic load with canola oil on glycemic control and cardiovascular risk factors: a randomized controlled trial. Diabetes Care. 2014;37(7):1806-14.
Nigam P, Bhatt S, Misra A, et al. Effect of a 6-month intervention with cooking oils containing a high concentration of monounsaturated fatty acids (olive and canola oils) compared with control oil in male Asian Indians with nonalcoholic fatty liver disease. Diabetes Technol Ther. 2014;16(4):255-61.
Iggman D, Gustafsson IB, Berglund L, Vessby B, Marckmann P, Risérus U. Replacing dairy fat with rapeseed oil causes rapid improvement of hyperlipidaemia: a randomized controlled study. J Intern Med. 2011;270(4):356-64.
Palomäki A, Pohjantähti-Maaroos H, Wallenius M, et al. Effects of dietary cold-pressed turnip rapeseed oil and butter on serum lipids, oxidized LDL and arterial elasticity in men with metabolic syndrome. Lipids Health Dis. 2010;9:137.
Karvonen HM, Tapola NS, Uusitupa MI, Sarkkinen ES. The effect of vegetable oil-based cheese on serum total and lipoprotein lipids. Eur J Clin Nutr. 2002;56(11):1094-101.
Kratz M, von Eckardstein A, Fobker M, et al. The impact of dietary fat composition on serum leptin concentrations in healthy nonobese men and women. J Clin Endocrinol Metab. 2002;87(11):5008-14.
Nielsen NS, Pedersen A, Sandström B, Marckmann P, Høy CE. Different effects of diets rich in olive oil, rapeseed oil and sunflower-seed oil on postprandial lipid and lipoprotein concentrations and on lipoprotein oxidation susceptibility. Br J Nutr. 2002;87(5):489-99.
Francois CA, Connor SL, Wander RC, Connor WE. Acute effects of dietary fatty acids on the fatty acids of human milk. Am J Clin Nutr. 1998;67(2):301-8.
Salar A, Faghih S, Pishdad GR. Rice bran oil and canola oil improve blood lipids compared to sunflower oil in women with type 2 diabetes: A randomized, single-blind, controlled trial. J Clin Lipidol. 2016;10(2):299-305.
Libuda L, Mesch CM, Stimming M, et al. Fatty acid supply with complementary foods and LC-PUFA status in healthy infants: results of a randomised controlled trial. Eur J Nutr. 2016;55(4):1633-44.
Negele L, Schneider B, Ristl R, et al. Effect of a low-fat diet enriched either with rapeseed oil or sunflower oil on plasma lipoproteins in children and adolescents with familial hypercholesterolaemia. Results of a pilot study. Eur J Clin Nutr. 2015;69(3):337-43.
Baril-Gravel L, Labonté ME, Couture P, et al. Docosahexaenoic acid-enriched canola oil increases adiponectin concentrations: a randomized crossover controlled intervention trial. Nutr Metab Cardiovasc Dis. 2015;25(1):52-9.
Gladine C, Combe N, Vaysse C, et al. Optimized rapeseed oil enriched with healthy micronutrients: a relevant nutritional approach to prevent cardiovascular diseases. Results of the Optim'Oils randomized intervention trial. J Nutr Biochem. 2013;24(3):544-9.
Gillingham LG, Robinson KS, Jones PJ. Effect of high-oleic canola and flaxseed oils on energy expenditure and body composition in hypercholesterolemic subjects. Metabolism. 2012;61(11):1598-605.
Rzehak P, Koletzko S, Koletzko B, et al.Growth of infants fed formula rich in canola oil (low erucic acid rapeseed oil). Clin Nutr. 2011;30(3):339-45.
Atefi M, Pishdad GR, Faghih S. The effects of canola and olive oils on insulin resistance, inflammation and oxidative stress in women with type 2 diabetes: a randomized and controlled trial. J Diabetes Metab Disord. 2018;17(2):85-91.
Raeisi-Dehkordi H, Amiri M, Humphries KH, Salehi-Abargouei A. The effect of canola oil on body weight and composition: A systematic review and meta-analysis of randomized controlled clinical trials. Adv Nutr. 2019;10(3):419-432.
Ghobadi S, Hassanzadeh-Rostami Z, Mohammadian F, Zare M, Faghih S. Effects of canola oil consumption on lipid profile: A systematic review and meta-analysis of randomized controlled clinical trials. J Am Coll Nutr. 2019;38(2):185-196.
Raeisi-Dehkordi H, Amiri M, Zimorovat A, et al. Canola oil compared with sesame and sesame-canola oil on glycaemic control and liver function in patients with type 2 diabetes: A three-way randomized triple-blind cross-over trial. Diabetes Metab Res Rev 2021;37(5):e3399.
Raeisi-Dehkordi H, Amiri M, Moghtaderi F, et al. Effects of sesame, canola and sesame-canola oils on body weight and composition in adults with type 2 diabetes mellitus: a randomized, triple-blind, cross-over clinical trial. J Sci Food Agric 2021;101(14):6083-6092.
Moghtaderi F, Amiri M, Zimorovat A, et al. The effect of canola, sesame and sesame-canola oils on body fat and composition in adults: a triple-blind, three-way randomised cross-over clinical trial. Int J Food Sci Nutr 2021;72(2):226-235.
Moghtaderi F, Amiri M, Raeisi-Dehkordi H, Zimorovat A, Mohyadini M, Salehi-Abargouei A. The effect of sesame, canola, and sesame-canola oils on cardiometabolic risk factors in overweight adults: a three-way randomized triple-blind crossover clinical trial. Phytother Res 2022;36(2):1043-1057.
Amiri M, Raeisi-Dehkordi H, Moghtaderi F, Zimorovat A, Mohyadini M, Salehi-Abargouei A. The effects of sesame, canola, and sesame-canola oils on cardiometabolic markers in patients with type 2 diabetes: a triple-blind three-way randomized crossover clinical trial. Eur J Nutr 2022;61(7):3499-3516.
Yahay M, Heidari Z, Allameh Z, Amani R. The effects of canola and olive oils consumption compared to sunflower oil, on lipid profile and hepatic steatosis in women with polycystic ovarian syndrome: a randomized controlled trial. Lipids Health Dis. 2021 Jan 29;20(1):7.
Zhang Y, Zhuang P, Wu F, et al. Cooking oil/fat consumption and deaths from cardiometabolic diseases and other causes: prospective analysis of 521,120 individuals. BMC Med. 2021 Apr 15;19(1):92.
Dobrzynska MA, Przyslawski J. The effect of camelina oil (a-linolenic acid) and canola oil (oleic acid) on lipid profile, blood pressure, and anthropometric parameters in postmenopausal women. Arch Med Sci. 2020 Mar 31;17(6):1566-74.
Davis KM, Petersen KS, Bowen KJ, et al. Effects of diets enriched with conventional or high-oleic canola oils on vascular endothelial function: A sub-study of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a randomized, crossover, controlled feeding study. Nutrients. 2022 Aug 18;14(16):3404.
Amiri M, Raeisi-Dehkordi H, Sarrafzadegan N, Forbes SC, Salehi-Abargouei A. The effects of canola oil on cardiovascular risk factors: A systematic review and meta-analysis with dose-response analysis of controlled clinical trials. Nutr Metab Cardiovasc Dis. 2020 Nov 27;30(12):2133-45.
Pourrajab B, Sharifi-Zahabi E, Soltani S, Shahinfar H, Shidfar F. Comparison of canola oil and olive oil consumption on the serum lipid profile in adults: a systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2022 Jul 22:1-15.
Select a condition to view a list of vitamins
CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
This copyrighted material is licensed from Therapeutic Research Center, LLC. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
Licensed from Therapeutic Research Center, LLC
Copyright © 1995-2025 by Therapeutic Research Center, LLC. All Rights Reserved.