Overview

Higenamine is a chemical found in several plants including aconite, asarum, lotus, Lamarck's bedstraw, sacred bamboo, and others. It might be unsafe.

Higenamine works like a stimulant. In some parts of the body it causes tissues to relax. In other parts of the body, such as the heart, it causes tissue to contract. It seems to increase heart contractions and speed up the heart rate.

People use higenamine for athletic performance, obesity, asthma, cough, and many other conditions, but there is no good scientific evidence to support these uses.

Higenamine is found in products promoted as pre-workoutsupplements, but it's not always listed on product labels. It's also not approved for use in dietary supplements and is prohibited in sports. It is on the World Anti-Doping Agency (WADA) Prohibited List. Don't confuse higenamine with aconite. These are not the same.



Uses & Effectiveness

We currently have no information for Higenamine overview.

Side Effects

When taken by mouth: Higenamine is possibly unsafe. Higenamine is one of the main chemicals in a plant called aconite. Aconite has been shown to cause serious heart-related side effects including irregular heartbeat and even death. It is possible that these effects are caused by higenamine.

Special Precautions and Warnings

When taken by mouth: Higenamine is possibly unsafe. Higenamine is one of the main chemicals in a plant called aconite. Aconite has been shown to cause serious heart-related side effects including irregular heartbeat and even death. It is possible that these effects are caused by higenamine.

Pregnancy and breast-feeding: There isn't enough reliable information to know if higenamine is safe to use when pregnant or breast feeding. Stay on the safe side and avoid use.

Irregular heartbeat: Higenamine might cause a rapid heartbeat. This could make irregular heartbeat worse. If you have an irregular heartbeat, do not take higenamine.

Surgery: Higenamine acts like a stimulant. It might interfere with surgery by increasing heart rate. Stop taking higenamine at least 2 weeks before a scheduled surgery.

Interactions

    Moderate Interaction

    Be cautious with this combination

  • Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) interacts with Higenamine

    Some medications are changed and broken down by the liver. Higenamine might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

  • Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with Higenamine

    Some medications are changed and broken down by the liver. Higenamine might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

  • Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with Higenamine

    Higenamine might slow blood clotting. Taking higenamine along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

  • Stimulant drugs interacts with Higenamine

    Stimulant drugs can speed up the nervous system and heart. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. Higenamine might also speed up the nervous system and heart. Taking higenamine along with stimulant drugs might cause serious problems such as an increased heart rate and high blood pressure.

    Minor Interaction

    Be watchful with this combination

  • Propranolol (Inderal) interacts with Higenamine

    Higenamine can stimulate the heart and cause it to beat faster and stronger. Taking propranolol might reduce this effect.

Dosing

Higenamine is found in pre-workout and weight loss supplements. But it's not approved for use in dietary supplements and isn't always included on product labels. It's also banned in sports by the World Anti-Doping Agency (WADA) and might be unsafe. Consult a healthcare professional before using.
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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is licensed from Therapeutic Research Center, LLC. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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