Overview

Hesperidin is a plant chemical that's classified as a "bioflavonoid." It's most commonly found in citrus fruits such as oranges. People use it as medicine.

Hesperidin might help blood vessels function better. It might also reduce swelling.

People use hesperidin for diabetes, high blood pressure, athletic performance, and many other conditions, but there is no scientific evidence to support any uses.

Uses & Effectiveness

Possibly Ineffective for

There is interest in using hesperidin for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Hesperidin is commonly consumed from citrus fruits. Hesperidin supplements are possibly safe for most people when taken in doses of 3 grams daily for up to 3 months. It's usually well tolerated.

Special Precautions and Warnings

When taken by mouth: Hesperidin is commonly consumed from citrus fruits. Hesperidin supplements are possibly safe for most people when taken in doses of 3 grams daily for up to 3 months. It's usually well tolerated.


Pregnancy and breast-feeding: Hesperidin is commonly consumed from citrus fruits. It is possibly safe to take hesperidin in larger doses with another plant chemical called diosmin when pregnant or breast-feeding.

Bleeding disorder: Hesperidin might slow blood clotting and increase the risk of bleeding. Hesperidin might make bleeding disorders worse.

Surgery: Hesperidin might increase the risk of bleeding or cause extra sleepiness during and after surgical procedures. Stop taking hesperidin at least 2 weeks before a scheduled surgery.

Interactions

    Moderate Interaction

    Be cautious with this combination

  • Celiprolol (Celicard) interacts with Hesperidin

    Hesperidin may reduce how much celiprolol the body absorbs. This might decrease the effects of celiprolol.

  • Diltiazem (Cardizem, others) interacts with Hesperidin

    Hesperidin may reduce how much diltiazem the body absorbs. This might decrease the effects of diltiazem.

  • Medications for high blood pressure (Antihypertensive drugs) interacts with Hesperidin

    Hesperidin might lower blood pressure. Taking hesperidin along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.

  • Medications moved by pumps in cells (P-glycoprotein substrates) interacts with Hesperidin

    Some medications are moved in and out of cells by pumps. Hesperidin might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.

  • Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with Hesperidin

    Hesperidin might slow blood clotting. Taking hesperidin along with medications that also slow blood clotting might increase the risk of bruising and bleeding and others.

  • Sedative medications (CNS depressants) interacts with Hesperidin

    Hesperidin might cause sleepiness and slowed breathing. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Taking hesperidin with sedative medications might cause breathing problems and/or too much sleepiness.

  • Verapamil (Calan, others) interacts with Hesperidin

    Hesperidin may increase how much verapamil the body absorbs. This might increase the effects and side effects of verapamil.

Dosing

Hesperidin is found in citrus fruits such as oranges. In supplements, hesperidin has most often been used by adults in doses of 450-1000 mg by mouth daily for 6-12 weeks. Speak with a healthcare provider to find out what dose might be best for a specific condition.
View References

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is licensed from Therapeutic Research Center, LLC. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
Licensed from Therapeutic Research Center, LLC
Copyright © 1995-2025 by Therapeutic Research Center, LLC. All Rights Reserved.