Overview

Diosmin is a chemical called a flavonoid that is found in some plants. It's most commonly found in citrus fruits.

Diosmin might work by reducing swelling and restoring normal vein function. Diosmin also seems to have antioxidant effects. Diosmin is often taken with other plant flavonoids like hesperidin.

Diosmin is most often used for hemorrhoids and poor blood flow. It's also used for back pain and many other conditions, but there's no strong scientific evidence to support most of these uses.

Uses & Effectiveness

Possibly Effective for

  • Poor circulation that can cause the legs to swell (chronic venous insufficiency or CVI). Taking diosmin by mouth with other flavonoids like hesperidin might help reduce pain by a small amount in people with CVI. It's not clear if taking diosmin alone helps.
  • Hemorrhoids. Taking diosmin by mouth with other flavonoids like hesperidin seems to reduce symptoms of hemorrhoids and might also help to keep hemorrhoids from coming back.
  • Leg sore caused by weak blood circulation (venous leg ulcer). Taking diosmin by mouth with other flavonoids like hesperidin while using compression dressings seems to help heal leg ulcers caused by poor circulation.

There is interest in using diosmin for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Diosmin is commonly consumed from citrus fruits. Diosmin supplements are possibly safe for most people when used short-term. Diosmin can cause some side effects such as stomach pain, diarrhea, dizziness, headache, and skin redness.

Special Precautions and Warnings

When taken by mouth: Diosmin is commonly consumed from citrus fruits. Diosmin supplements are possibly safe for most people when used short-term. Diosmin can cause some side effects such as stomach pain, diarrhea, dizziness, headache, and skin redness.

Pregnancy and breast-feeding: Diosmin is commonly consumed from citrus fruits. Diosmin supplements are possibly safe to take with other flavonoids like hesperidin when pregnant or breast-feeding.

Surgery: Diosmin might prolong bleeding and might increase the risk of bleeding during and after surgical procedures. Stop taking diosmin at least 2 weeks before a scheduled surgery.

Interactions

    Moderate Interaction

    Be cautious with this combination

  • Carbamazepine (Tegretol) interacts with Diosmin

    Diosmin might decrease how quickly the body breaks down carbamazepine. Taking diosmin along with carbamazepine might increase the effects and side effects of carbamazepine.

  • Fexofenadine (Allegra) interacts with Diosmin

    Some medications, such as fexofenadine, are moved by pumps in cells. Diosmin might affect these pumps and increase how much of some medications get absorbed by the body. This might cause more side effects from some medications, like fexofenadine.

  • Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with Diosmin

    Some medications are changed and broken down by the liver. Diosmin might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

  • Chlorzoxazone (Parafon Forte, Paraflex) interacts with Diosmin

    Diosmin might decrease how quickly the body breaks down chlorzoxazone. Taking diosmin along with chlorzoxazone might increase the effects and side effects of chlorzoxazone.

  • Diclofenac (Voltaren, others) interacts with Diosmin

    Diosmin might decrease how quickly the body breaks down diclofenac. Taking diosmin along with diclofenac might increase the effects and side effects of diclofenac.

  • Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with Diosmin

    Some medications are changed and broken down by the liver. Diosmin might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

  • Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates) interacts with Diosmin

    Some medications are changed and broken down by the liver. Diosmin might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

  • Medications moved by pumps in cells (P-Glycoprotein Substrates) interacts with Diosmin

    Some medications are moved in and out of cells by pumps. Diosmin might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication..

  • Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with Diosmin

    Diosmin might slow blood clotting. Taking diosmin along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

Dosing

Diosmin is commonly eaten in citrus fruits. As a supplement, it's usually taken in combination with other flavonoids, particularly hesperidin. It's most often been used by adults in doses of 450-1350 mg by mouth daily for 1-6 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.
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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is licensed from Therapeutic Research Center, LLC. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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