Overview

Indole-3-carbinol comes from a substance called glucobrassicin, which is found in cruciferous vegetables such as broccoli, cauliflower, and kale.

The amount of glucobrassicin found in vegetables varies depending on the plant, soil, rainfall, amount of sunlight, and other factors. Indole-3-carbinol is formed when these vegetables are cut, chewed or cooked. It might have effects that prevent the growth of certain types of cancer cells.

People use indole-3-carbinol for cancer prevention, liver disease, fibromyalgia, and many other conditions, but there is no good scientific evidence to support these uses.

Don't confuse indole-3-carbinol with cruciferous vegetables, such as broccoli, or with other chemicals found in these vegetables such as ascorbigen, diindolylmethane, or sulforaphane. These are not the same.



Uses & Effectiveness

We currently have no information for Indole-3-Carbinol overview.

Side Effects

When taken by mouth: Indole-3-carbinol is possibly safe when used in doses up to 400 mg daily for 3-76 months. Side effects might include balance problems, diarrhea, nausea, rash, and tremors.

Special Precautions and Warnings

When taken by mouth: Indole-3-carbinol is possibly safe when used in doses up to 400 mg daily for 3-76 months. Side effects might include balance problems, diarrhea, nausea, rash, and tremors.

Pregnancy and breast-feeding: There isn't enough reliable information to know if indole-3-carbinol is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Children: Indole-3-carbinol is possibly safe when taken by mouth appropriately. Doses of 6-17 mg/kg body weight have been safely used in children and teenagers for 12-76 months.

Bleeding conditions: Indole-3-carbinol might slow blood clotting. Taking indole-3-carbinol might increase the risk of bleeding in people with bleeding disorders.

Surgery: Indole-3-carbinol might slow blood clotting. Taking indole-3-carbinol might cause bleeding complications during surgery. Stop taking indole-3-carbinol at least 2 weeks before surgery.

Interactions

    Moderate Interaction

    Be cautious with this combination

  • Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with Indole-3-Carbinol

    Some medications are changed and broken down by the liver. Indole-3-carbinol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

  • Estrogens interacts with Indole-3-Carbinol

    Indole-3-carbinol might interfere with the effects of estrogen therapy.

  • Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with Indole-3-Carbinol

    Indole-3-carbinol might slow blood clotting. Taking indole-3-carbinol along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

Dosing

Indole-3-carbinol has most often been used by adults at a dose of 200 mg by mouth twice daily for up to 5 years. Speak with a healthcare provider to find out what dose might be best for a specific condition.
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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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