510(k) Premarket Notification. Medical Maggots. K033391. U.S. Food and Drug Administration Website. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpmn/pmn.cfm?ID=K033391.
Sherman R. Age-old therapy gets new approval. Adv Skin Wound Care 2005;18(1):12-5.
Thomas S, Jones M, Wynn K, Fowler T. The current status of maggot therapy in wound healing. Br J Nurs 2001;10(22 Suppl):S5-8, S10, S12.
Mumcuoglu KY, Taylan Ozkan A. [The treatment of suppurative chronic wounds with maggot debridement therapy]. Turkiye Parazitol Derg 2009;33(4):307-15.
Panuncialman J, Falanga V. The science of wound bed preparation. Clin Plast Surg 2007;34(4):621-32.
Dumville JC, Worthy G, Bland JM, et al. Larval therapy for leg ulcers (VenUS II): randomised controlled trial. BMJ 2009;338:b773.
Dumville JC, Worthy G, Soares MO, et al. VenUS II: a randomised controlled trial of larval therapy in the management of leg ulcers. Health Technol Assess 2009;13(55):1-182, iii-iv.
Wollina U, Liebold K, Schmidt WD, et al. Biosurgery supports granulation and debridement in chronic wounds--clinical data and remittance spectroscopy measurement. Int J Dermatol 2002;41(10):635-39.
Nuesch R, Rahm G, Rudin W, et al. Clustering of bloodstream infections during maggot debridement therapy using contaminated larvae of Protophormia terraenovae. Infection 2002;30(5):306-9.
Steenvoorde P, Oskam J. Bleeding complications in patients treated with maggot debridement therapy. Int J Low Extrem Wounds 2005;4(1):57-8.
Church JC. Re: Bleeding complications in patients treated with maggot debridement therapy, Steenvoorde P and Oskam J, IJLEW 2005;4(1):57-58. Int J Low Extrem Wounds 2005;4(1):59.
Steenvoorde P, van Doorn LP. Maggot debridement therapy: serious bleeding can occur: report of a case. J Wound Ostomy Continence Nurs 2008;35(4):412-4.
Courtenay M, Church JC, Ryan TJ. Larva therapy in wound management. J R Soc Med 2000;93(2):72-4.
Sherman RA, Sherman J, Gilead L, et al. Maggot debridement therapy in outpatients. Arch Phys Med Rehabil 2001;82(9):1226-9.
Steenvoorde P, Budding T, Oskam J. Determining pain levels in patients treated with maggot debridement therapy. J Wound Care 2005;14(10):485-8.
Sherman RA, Shimoda KJ. Presurgical maggot debridement of soft tissue wounds is associated with decreased rates of postoperative infection. Clin Infect Dis 2004;39(7):1067-70.
Sherman RA. Maggot therapy for treating diabetic foot ulcers unresponsive to conventional therapy. Diabetes Care 2003;26(2):446-51.
Hall S. A review of maggot debridement therapy to treat chronic wounds. Br J Nurs 2010;19(15):S26, S28-S26, S31.
Sherman RA. Maggot versus conservative debridement therapy for the treatment of pressure ulcers. Wound Repair Regen 2002;10(4):208-14.
Amin AM. In vitro effect of ivermectin on the larvae of Lucilia sericata meigen in Saudi Arabia. J Egypt Soc Parasitol 1998;28(1):53-8.
Sherman RA. A new dressing design for use with maggot therapy. Plast Reconstr Surg 1997;100(2):451-6.
Sherman RA, Wyle F, Vulpe M. Maggot therapy for treating pressure ulcers in spinal cord injury patients. J Spinal Cord Med 1995;18(2):71-4.
Wayman J, Nirojogi V, Walker A, et al. The cost effectiveness of larval therapy in venous ulcers. J Tissue Viability 2000;10(3):91-4.
Cambal M, Labas P, Kozanek M, et al. Maggot debridement therapy. Bratisl Lek Listy 2006;107(11-12):442-4.
Paul AG, Ahmad NW, Lee HL, et al. Maggot debridement therapy with Lucilia cuprina: a comparison with conventional debridement in diabetic foot ulcers. Int Wound J 2009;6(1):39-46.
Tantawi TI, Gohar YM, Kotb MM, et al. Clinical and microbiological efficacy of MDT in the treatment of diabetic foot ulcers. J Wound Care 2007;16(9):379-83.
Armstrong DG, Salas P, Short B, et al. Maggot therapy in "lower-extremity hospice" wound care: fewer amputations and more antibiotic-free days. J Am Podiatr Med Assoc 2005;95(3):254-7.
Hwang JH, Modi HN, Suh SW, et al. Maggot debridement therapy for postsurgical wound infection in scoliosis: a case series in five patients. Spine (Phila Pa 1976) 2011;36(4):313-9.
Wolff H, Hansson C. Larval therapy--an effective method of ulcer debridement. Clin Exp Dermatol 2003;28(2):134-7.
Grassberger M, Frank C. [Wound healing by steril fly larvas: basic mechanical, biochemical and microbiological principles]. Wien Med Wochenschr 2003;153(9-10):198-201.
Falabella AF. Debridement and wound bed preparation. Dermatol Ther 2006;19(6):317-25.
Turkmen A, Graham K, McGrouther DA. Therapeutic applications of the larvae for wound debridement. J Plast Reconstr Aesthet Surg 2010;63(1):184-8.
Bonn D. Maggot therapy: an alternative for wound infection. Lancet 2000;356(9236):1174.
Robinson F. Maggot therapy for wound healing. Practice Nurse 2010;39(3):28-9.
Telford G, Brown AP, Kind A, et al. Maggot chymotrypsin I from Lucilia sericata is resistant to endogenous wound protease inhibitors. Br J Dermatol 2011;164(1):192-6.
Cerovsky V, Zdarek J, Fucik V, et al. Lucifensin, the long-sought antimicrobial factor of medicinal maggots of the blowfly Lucilia sericata. Cell Mol Life Sci 2010;67(3):455-66.
Chambers L, Woodrow S, Brown AP, et al. Degradation of extracellular matrix components by defined proteinases from the greenbottle larva Lucilia sericata used for the clinical debridement of non-healing wounds. Br J Dermatol 2003;148(1):14-23.
Schmidtchen A, Wolff H, Rydengard V, Hansson C. Detection of serine proteases secreted by Lucilia sericata in vitro and during treatment of a chronic leg ulcer. Acta Derm Venereol 2003;83(4):310-1.
Vistnes LM, Lee R, Ksander GA. Proteolytic activity of blowfly larvae secretions in experimental burns. Surgery 1981;90(5):835-41.
Bexfield A, Bond AE, Morgan C, et al. Amino acid derivatives from Lucilia sericata excretions/secretions may contribute to the beneficial effects of maggot therapy via increased angiogenesis. Br J Dermatol 2010;162(3):554-62.
Margolin L, Gialanella P. Assessment of the antimicrobial properties of maggots. Int Wound J 2010;7(3):202-4.
Bexfield A, Nigam Y, Thomas S, Ratcliffe NA. Detection and partial characterisation of two antibacterial factors from the excretions/secretions of the medicinal maggot Lucilia sericata and their activity against methicillin-resistant Staphylococcus aureus (MRSA). Microbes Infect 2004;6(14):1297-1304.
Huberman L, Gollop N, Mumcuoglu KY, et al. Antibacterial properties of whole body extracts and haemolymph of Lucilia sericata maggots. J Wound Care 2007;16(3):123-7.
Thomas S, Andrews AM, Hay NP, Bourgoise S. The anti-microbial activity of maggot secretions: results of a preliminary study. J Tissue Viability 1999;9(4):127-32.
Andersen AS, Sandvang D, Schnorr KM, et al. A novel approach to the antimicrobial activity of maggot debridement therapy. J Antimicrob Chemother 2010;65(8):1646-54.
Khater, H. F. and Khater, D. F. The insecticidal activity of four medicinal plants against the blowfly Lucilia sericata (Diptera: Calliphoridae). Int J Dermatol. 2009;48(5):492-497.
Sun X, Jiang K, Chen J, et al. A systematic review of maggot debridement therapy for chronically infected wounds and ulcers. Int J Infect Dis. 2014;25:32-7.
Tian X, Liang XM, Song GM, Zhao Y, Yang XL. Maggot debridement therapy for the treatment of diabetic foot ulcers: a meta-analysis. J Wound Care. 2013;22(9):462-9.
Opletalová K, Blaizot X, Mourgeon B, et al. Maggot therapy for wound debridement: a randomized multicenter trial. Arch Dermatol. 2012;148(4):432-8.
Malekian A, Esmaeeli Djavid G, Akbarzadeh K, et al. Efficacy of Maggot Therapy on Staphylococcus aureus and Pseudomonas aeruginosa in Diabetic Foot Ulcers: A Randomized Controlled Trial. J Wound Ostomy Continence Nurs. 2019;46(1):25-29.
Nair HK, Ahmad NW, Ismail AA, et al. Maggot debridement therapy to treat hard-to-heal diabetic foot ulcers: a single-centre study. J Wound Care. 2021 Dec 1;30(Sup12):s30-s36.
Sirekbasan S, Polat E, Cangel U. The effect of bacterial colonization and maggot debridement treatment on wound healing in chronic venous leg ulcers. Clin Lab. 2021;67(5):1289-92.
Bueide P, Hunt J, Bande D, Guerrero DM. Maggot wound therapy associated with Wohlfahrtiimonas chitiniclastica blood infection. Cureus. 2021 Jan 4;13(1):e12471.
Kecici AS, Polat E, Kutlubay Z. Efficacy of maggot debridement therapy on refractory leg ulcers of Behçet disease: an open-label study. Clin Exp Dermatol. 2021 Jul;46(5):834-41.
Siavash M, Najjarnezhad A, Mohseni N, Abtahi SM, Karimy A, Sabzevari MH. Efficacy of maggot debridement therapy on refractory atypical diabetic foot ulcers: an open-label study. Int J Low Extrem Wounds. 2021 Dec;20(4):315-20.
Dehghan O, Tabaie SM, Rafinejad J, et al. A parallel randomized clinical trial for comparison of two methods of maggot therapy, free-range larvae and larval-bag, in diabetic ulcer (Wagner 2). Int J Low Extrem Wounds. 2021 Sep 17:15347346211044295.
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