Enzyme Therapy: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Enzymes are molecules that the body needs to perform various processes. Enzyme therapy involves the use of enzymes for health.

Enzymes are used for a number of conditions, including cystic fibrosis, digestion problems due to a disorder of the pancreas (pancreatic insufficiency), and inability to properly digest the sugar lactose (lactose intolerance).

Enzyme therapy is most commonly used to replace a specific enzyme which should be made by the body. It might also be used to help break down food or tissue.

How does it work ?

Enzyme therapy is most commonly used to replace a specific enzyme which should be made by the body. It might also be used to help break down food or tissue.

Uses & Effectiveness

Insufficient Evidence for

<p>Enzyme therapy can involve numerous enzymes that are used alone or in combination. See specific enzyme monographs for effectiveness information.</p>

Side Effects

Special Precautions and Warnings

Enzyme therapy can involve numerous enzymes that are used alone or in combination. See specific enzyme monographs for safety information.

Pregnancy and breast-feeding: See specific enzymes for safety information.

Interactions

We currently have no information for Enzyme Therapy overview.

Dosing

See specific enzymes for dosing information.

View References

REFERENCES:

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Rosenberg L, Krieger Y, Bogdanov-Berezovski A, et al. A novel rapid and selective enzymatic debridement agent for burn wound management: a multi-center RCT. Burns. 2014;40(3):466-74.

Biziulevicius GA. Where do the immunostimulatory effects of oral proteolytic enzymes ('systemic enzyme therapy') come from? Microbial proteolysis as a possible starting point. Med Hypotheses. 2006;67(6):1386-8.

de la Iglesia-García D, Huang W, Szatmary P, et al. Efficacy of pancreatic enzyme replacement therapy in chronic pancreatitis: systematic review and meta-analysis. Gut. 2017;66(8):1354-1355.

El Dib R, Gomaa H, Carvalho RP, et al. Enzyme replacement therapy for Anderson-Fabry disease. Cochrane Database Syst Rev. 2016;7:CD006663.

Fuhrmann G, Leroux JC. Improving the stability and activity of oral therapeutic enzymes-recent advances and perspectives. Pharm Res. 2014;31(5):1099-105.

Rombach SM, Smid BE, Linthorst GE, Dijkgraaf MG, Hollak CE. Natural course of Fabry disease and the effectiveness of enzyme replacement therapy: a systematic review and meta-analysis: effectiveness of ERT in different disease stages. J Inherit Metab Dis. 2014 37(3):341-52.

Shemesh E, Deroma L, Bembi B, et al. Enzyme replacement and substrate reduction therapy for Gaucher disease. Cochrane Database Syst Rev. 2015 Mar 27;(3):CD010324.

Somaraju UR, Solis-Moya A. Pancreatic enzyme replacement therapy for people with cystic fibrosis. Cochrane Database Syst Rev. 2016;11:CD008227.

UmaMaheswari T, Hemalatha T, Sankaranarayanan P, Puvanakrishnan R. Enzyme Therapy: Current Perspectives. Indian J Exp Biol. 2016;54(1):7-16.

Valentine R, Athanasiadis T, Moratti S, Hanton L, Robinson S, Wormald PJ. The efficacy of a novel chitosan gel on hemostasis and wound healing after endoscopic sinus surgery. Am J Rhinol Allergy. 2010;24(1):70-5.

Pollard HB, Block GE. Rapid dissolution of phytobezoar by cellulase enzyme. Am J Surg. 1968;116:933-936.

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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