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6 Conditions That Can Mimic Prostate Cancer

Do Prostate Symptoms Mean Cancer?
Not always. You may be scouring the internet to learn about early prostate symptoms such as:
Pain when you pee
Blood in your pee
Having to pee more at night
You may wonder if you have cancer of the prostate, the small gland under your bladder that helps make semen. But there are lots of other medical conditions that can mimic early prostate symptoms.
Many of these noncancerous conditions are easily treated. Here's six of the most common ones.
What Is Benign Prostatic Hyperplasia (BPH)?
It's when your prostate gets bigger than normal (enlarged). As you get older, the prostate often gets bigger. The larger gland can put pressure on your bladder and urethra, the tube that removes pee from your body.
So BPH can mimic prostate cancer symptoms such as:
Frequent, urgent need to pee
Peeing more often at night
Pain when you pee
Blood in your pee
Weak urine stream
Dribbling after you pee
How Can Prostatitis Mimic Prostate Cancer?
Prostatitis happens when your prostate gland swells and makes it hard to pee or hurt to pee.
Symptoms depend on the cause, but can mimic prostate cancer symptoms such as:
Urgent need to pee
Blood in the urine
Cloudy urine
Painful ejaculation
But prostatitis is caused by bacteria and nearby infections, or prostate swelling from autoimmune, trauma, or chemical irritants.
What Is Epididymitis?
Bacteria or sexually transmitted diseases can inflame the coiled tube behind your testicles that stores and carries sperm, a condition called epididymitis.
Symptoms for epididymis can look like prostate cancer:
Pain when you pee
Swollen, discolored, or warm scrotum
Sore, tender testicles on one side
Penis discharge
Bloody semen
Pelvic pain or discomfort
How Urinary Tract Infection (UTI) Symptoms Mimic Prostate Cancer
Your urinary tract makes and stores pee (urine). Pee is filtered water and waste from your body, stored in your bladder where it exits through the urethra. If bacteria enter your urinary tract, they can cause inflammation and infection.
Some UTI symptoms overlap with prostate cancer:
Pain in your flank, abdomen, pelvis, or lower back
Urgent, frequent need to pee
Pain or blood when you pee
Pelvic pressure
Sexually Transmitted Diseases (STDs) That Look Like Prostate Cancer
Some STDs can mimic early prostate symptoms, such as chlamydia, gonorrhea, and trichomonas vaginalis.
These STDs can cause chronic inflammation in your prostate, and you may get symptoms that mimic prostate cancer:
Waking at night to pee
Pain while peeing
Belly pain
Painful, swollen testicles
Research is mixed as to whether STDs raise prostate cancer risk.
What Is Malakoplakia?
It's a rare condition that often shows up in your urinary tract, but it can affect any organ. Doctors think that E. coli bacteria may lower your macrophages, a white blood cell type. You're at higher risk for malakoplakia if you have UTIs, diabetes, cancer, or a weakened immune system.
Malakoplakia symptoms are often mistaken for prostate cancer:
Nodules and masses
Pain when you pee
Frequent, urgent need to pee
Blood in the urine
Flank pain
Conditions That Mimic Late-Stage Prostate Cancer
If not treated early, prostate cancer can spread to other parts of your body like your lungs, bones, and liver.
Later-stage prostate cancer can cause symptoms like:
Fatigue
Bone pain
Unexplained weight loss
Bloody cough
Poor appetite
Bones that break easily
Several other conditions share these symptoms and include:
Osteoporosis
Rheumatoid arthritis
Lung cancer
Pneumonia
HIV
When to See to Your Doctor
Sometimes you can get symptoms for infection or an enlarged prostate that can cause health issues.
If you get any of these symptoms, get medical care right away:
- Get up to urgently pee many times during the night
- Frequently get an urge to pee
- Blood in your pee or semen
- Pain or burning when you pee
- Painful ejaculation
- Serious pain or stiffness in lower back, hips, pelvic or rectal area, or upper thighs
- Urine dribbles
Photo Credit: iStock/Getty Images
SOURCES:
Cancers: “Prostate Cancer and Its Mimics—A Pictorial Review.”
Mayo Clinic: “Prostatitis,” “Epididymitis,” “Benign prostatic hyperplasia (BPH).”
Cleveland Clinic: “Urinary Tract Infections,” “Nongonococcal Urethritis,” “Prostate Cancer.”
Cureus: "Prostatic Malakoplakia as a Mimic of Prostate Cancer Progression."
Bladder: “Recurrent bladder malakoplakia: A rare bladder lesion mimicking malignancy.”
Frontiers in Oncology: “Case report: Prostatic malakoplakia: a rare disease that has a profile mimicking prostate cancer.”
Journal of Endourology Case Reports: “Malakoplakia of the Prostate as a Mimicker of Prostate Cancer on Prostate Health Index and Magnetic Resonance Imaging-Fusion Prostate Biopsy: A Case Report.”
Case Reports in Emergency Medicine: “Metastatic Prostate Cancer Mimicking Polymyalgia Rheumatica.”
Cancer Research UK: “Symptoms of metastatic prostate cancer.”
National Institute on Aging: "Prostate Problems."