If you have multiple sclerosis (MS), extreme tiredness and low energy — also called fatigue — can be a very troubling symptom. To beat fatigue, doctors will most likely recommend lifestyle changes and nondrug treatments first. But if you try those, and you’re still dragging, your health care provider might try you out on a medication that could boost energy and alertness.
While no medications are specifically FDA-approved for the treatment of MS-related fatigue, doctors may prescribe drugs used to treat other conditions associated with fatigue, such as narcolepsy and shift work disorder. These medications may help with fatigue in some people with MS.
What to Know About Medications for MS Fatigue
Before you start medications for your MS fatigue, there are a few things you should keep in mind.
The prescription medications used off-label to treat MS fatigue are not a perfect or complete solution. They help some people, but the benefits aren’t major. People tend to see modest improvements in their energy levels.
On the flip side, some of these medications can come with unpleasant side effects, such as heart palpitations, anxiety, and insomnia. For some people, these side effects outweigh the benefits.
So, your doctor may recommend you try lifestyle changes, energy conservation strategies, and nondrug treatments, such as occupational therapy, before turning to medication for fatigue.
What Should I Avoid if I Have MS Fatigue?
If you have MS-related fatigue, try to avoid the following:
- Caffeine: Can cause dehydration and sleep disturbances, both of which can worsen fatigue.
- Muscle relaxers: Often prescribed for MS-related spasticity, they can cause drowsiness and sedation, making fatigue feel worse.
- Antihistamines: Can cause drowsiness, making fatigue seem worse.
