Along with traditional headache medications, other drugs -- like antidepressants -- can help you have fewer and less-severe headaches.
| Generic Name | Brand Name | Possible Side Effects |
| Amitriptyline | Fatigue, dry mouth, weight gain, constipation, drowsiness, and blurred vision. Older adults also may feel confusion or faintness. | |
| Desipramine | Norpramin | Dizziness, drowsiness, dry mouth, headache, increased appetite, nausea, tiredness, weakness, weight gain |
| Doxepin | Silenor | Dizziness, drowsiness, dry mouth, headache, increased appetite, nausea, tiredness, weakness, weight loss |
| Imipramine | Tofranil | Dizziness, drowsiness, dry mouth, weakness, weight gain |
| Nortriptyline | Pamelor | Dizziness, drowsiness, dry mouth, headache, increased appetite, nausea, tiredness, weakness, weight gain |
| Protriptyline | Dry mouth, weight gain, constipation |
Other Antidepressants Used in Headache Prevention
| Generic Name | Brand Name | Possible Side Effects |
| Fluoxetine | Prozac | Nausea, dry mouth, appetite changes, agitation |
| Nefazodone | Blurred vision, lightheadedness, clumsiness, ringing in the ears, skin rash, itching | |
| Paroxetine | Paxil | Fatigue, weight gain |
| Sertraline | Zoloft | Insomnia, restlessness |
| Venlafaxine | Effexor | Vision changes, low sex drive, headaches |
| Citalopram | Celexa | Drowsiness, nausea, insomnia, dry mouth, sweating |
| Escitalopram | Lexapro | Ejaculating too fast or too slow, insomnia, headache, drowsiness, diarrhea, nausea |
| Trazodone | Oleptro | Dizziness, lightheadedness, drowsiness, dry mouth, headache, nausea and vomiting, a bad taste in your mouth |
| Bupropion | Wellbutrin | Agitation, anxiety, buzzing or ringing in ears, skin rash, hives, itching |
| Phenelzine | Nardil | Chills, cold sweats, confusion, dizziness or lightheadedness when you get up, overactive reflexes |
