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Overview: Brinsupri is used to treat certain people with a specific problem that can make it hard to breathe. Common side effects can include infections in the nose or throat, headache, and high blood pressure. Visit your dentist for regular dental checkups while taking this medicine. If you have any new gum or tooth symptoms, call your dentist and tell your health care provider. If you get any skin changes like dry or thickened skin, tell your health care provider right away.

Uses

What is Brinsupri used for?

Brinsupri (brensocatib) is commonly used to treat certain people with bronchiectasis that is not from cystic fibrosis. 

Brinsupri may also be used for other conditions as determined by your health care provider.

How does Brinsupri work (mechanism of action)?

Air moves in and out of your lungs through tubes called bronchi. Bronchi are a part of your respiratory system. Breathing may become hard when these tubes become thickened from repeated inflammation that may be caused by infections. 

Brinsupri blocks an enzyme in the body called dipeptidyl peptidase 1 (DPP1). This enzyme normally “switches on” certain proteins in some of your white blood cells, called neutrophils. When these proteins are overactive, they can cause harmful inflammation. By blocking DPP1, Brinsupri seems to help reduce the activity of these proteins, which may lower inflammation.

How is Brinsupri supplied (dosage forms)?

Brands and other names

  • Brinsupri

Dosage forms and strengths

  • 10 mg oral tablets
  • 25 mg oral tablets

How should I store Brinsupri?

Brinsupri should be stored in its original container at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.

Side Effects

What are the most common side effects of Brinsupri?

The most common side effects of Brinsupri are listed below. Tell your health care provider if you have any of these side effects that bother you.

There may be other side effects of Brinsupri that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Brinsupri?

While less common, the most serious side effects of Brinsupri are described below, along with what to do if they happen.

Severe Allergic Reactions. Brinsupri may cause allergic reactions, which can be serious. Stop taking Brinsupri and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use Brinsupri?

Allergies to Ingredients. People who are allergic to any of the following should not take Brinsupri.

  • Brensocatib
  • Brinsupri
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Brinsupri.

What should I know about Brinsupri before using it?

Do not take Brinsupri unless it has been prescribed to you by a health care provider. Take it as prescribed.

Do not share Brinsupri with other people, even if they have the same condition as you. It may harm them.

Keep Brinsupri out of the reach of children.

Brinsupri may cause a rash, dry skin, or hyperkeratosis (thickening and hardening of your skin). If you notice any of these things, tell your health care provider right away. Your health care provider may refer you to a dermatologist to have your skin more closely checked. 

Brinsupri may cause changes or problems with your gums or teeth. Brush and floss your teeth as recommended by your dentist. Keep any dental appointments that you have or are recommended by your health care provider. If you get any gum or tooth symptoms, call your dentist and tell your health care provider.

What should I tell my health care provider before using Brinsupri?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Brinsupri is right for you.

In particular, make sure that you discuss any of the following.

Vaccines. Talk with your health care provider about any vaccines that you may need. You should not receive certain vaccines right before or while taking Brinsupri. Tell your health care provider about any vaccines you have recently received or have scheduled.

Other Medicines and Supplements. Brinsupri may interact with other medicines and supplements. Before taking Brinsupri, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Pregnancy. It is not known if or how Brinsupri could affect pregnancy or harm an unborn baby. Tell your health care provider if you are pregnant or plan to become pregnant.

Breastfeeding. It is not known if Brinsupri passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should take Brinsupri while breastfeeding.

How can I get more information about Brinsupri?

For more information about Brinsupri, you can visit the drugmaker’s website at www.brinsupri.com or call them at 833-LIGHT-00 or (833-544-4800).

Interactions

Does Brinsupri interact with foods or drinks?

There are no known interactions between Brinsupri and foods or drinks.

It is unknown if drinking alcohol will affect Brinsupri.

Does Brinsupri interact with other medicines (drug interactions)?

Brinsupri may interact with certain medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Brinsupri?

If you or someone else has used too much Brinsupri, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Brinsupri?

If you miss a dose, skip the missed dose. Take the next dose when you normally should. Do not take double or extra doses.