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Overview: Tryvio is a medicine that is used with other medicines to treat high blood pressure. Both anemia and fluid retention are common side effects. Tell your health care provider right away if you have unusual weight gain or swelling of your ankles or legs. Do not get pregnant while taking Tryvio and for one month after your last dose. Talk to your health care provider about your birth control options, including emergency contraception in case of unprotected sex or birth control failure.

Uses

What is Tryvio used for?

Tryvio (aprocitentan) is used for the treatment of high blood pressure in certain people who are already taking other medicines to lower blood pressure.

Tryvio may also be used for other conditions as determined by your health care provider.

How does Tryvio work (mechanism of action)?

A substance in your body called endothelin-1 can cause problems that can increase blood pressure when it binds to its receptors. Examples of these problems are increased sympathetic nervous system activity and an increased amount of a hormone called aldosterone. Tryvio works by preventing endothelin-1 from binding to its receptors. 

This medicine works differently from other medicines for high blood pressure. Lowering of blood pressure was noted in a study of people who took at least three other medicines for blood pressure, such as an angiotensin receptor blocker (ARB), a calcium channel blocker (CCB), a beta-blocker, and a diuretic.

How is Tryvio supplied (dosage forms)?

Brands and other names

  • Tryvio

Dosage forms and strengths

  • 12.5 mg oral tablets

How should I store Tryvio?

Tryvio should be stored in the original container at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.

Only remove a tablet from the blister pack when you are ready to take it. If your medicine comes in a bottle, replace the cap on the bottle each time after you open it. Do not throw away the desiccant. The medicine needs to be protected from both light and moisture.

Side Effects

What are the most common side effects of Tryvio?

The most common side effects of Tryvio are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Fluid retention (see below)
  • Anemia

There may be other side effects of Tryvio that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Tryvio?

While less common, the most serious side effects of Tryvio are described below, along with what to do if they happen.

Severe Allergic Reactions. Tryvio may cause allergic reactions, which can be serious. Stop taking Tryvio and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Liver Damage. Liver damage, also called hepatotoxicity, can happen when taking Tryvio. Keep all appointments to have your blood checked. Your health care provider may look for increases in liver enzymes in your blood. Stop taking Tryvio and get emergency help if you have any of the following symptoms of liver damage.

  • Nausea or vomiting
  • Stomach or belly pain
  • Fever
  • Weakness or unusual tiredness
  • Itching
  • Loss of appetite
  • Light-colored poop
  • Dark-colored urine (pee)
  • Your skin or the whites of your eyes turning yellowish in color (also called jaundice)

Fluid Retention (Edema). Tryvio can cause fluid retention, also called edema. Fluid retention can cause serious issues in people with certain conditions, such as heart failure or kidney problems. Call your health care provider right away if you have any of the following symptoms. 

  • Chest pain
  • Irregular heartbeat
  • Shortness of breath
  • Stretched or shiny skin
  • Swollen body parts, such as the belly or ankles
  • Sudden weight gain

Warnings & Precautions

Who should not use Tryvio?

Allergies to Ingredients. People who are allergic to any of the following should not take Tryvio.

  • Aprocitentan
  • Tryvio
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Tryvio.

Pregnancy. Do not take Tryvio if you are pregnant. If you become pregnant or think you may be pregnant, contact your health care provider right away. See the Pregnancy section for more details.

What should I know about Tryvio before using it?

Do not take Tryvio unless it has been prescribed to you by a health care provider. Take it as prescribed.

Do not share Tryvio with other people, even if they have the same condition as you. It may harm them.

Keep Tryvio out of the reach of children.

Swallow Tryvio whole.

Tryvio commonly lowers the amount of red blood cells in your blood. Keep all appointments to have your blood checked.

People who are aged 65 years or older can be at a greater risk of some side effects from Tryvio. Talk to your health care provider about your risks if you are in this age group.

If you are an adolescent who begins to get a monthly period (menstruation), tell your health care provider right away. You now have the possibility of becoming pregnant. See the Pregnancy section for more details.

Tryvio may make it hard for you to get your partner pregnant. If you have concerns, talk to your health care provider.

What should I tell my health care provider before using Tryvio?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Tryvio is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have any of the following.

  • Liver problems
  • Heart problems, such as heart failure
  • Kidney problems
  • Anemia

Pregnancy. Tryvio may cause death or serious harm to a fetus. If you can become pregnant, a negative pregnancy test is necessary before starting Tryvio. You will also need to use effective birth control before starting this medicine, while you are taking Tryvio, and for one month after your last dose. Talk to your health care provider about your birth control options, including emergency contraception in case of unprotected sex or birth control failure. Tell your health care provider right away if you are pregnant, think you may be pregnant, or plan to become pregnant.

Breastfeeding. Do not breastfeed if you take Tryvio. It is not known if Tryvio can pass into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed.

How can I get more information about Tryvio?

For more information about Tryvio, you can visit the drugmaker’s website at www.tryvio.com or call them at 833-400-9611.

Interactions

Does Tryvio interact with foods or drinks?

There are no known interactions between Tryvio and foods or drinks.

It is unknown if drinking alcohol will affect Tryvio.

Does Tryvio interact with other medicines (drug interactions)?

Tryvio may interact with certain medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Tryvio?

If you or someone else has used too much Tryvio, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Tryvio?

If you miss a dose, skip the missed dose and only take the next dose. Do not take two doses on the same day. Do not take double or extra doses.