Daxxify (daxibotulinumtoxinA-lanm): Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

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Overview: Daxxify is commonly used to treat cervical dystonia and frown lines between your eyebrows. The most common side effects are headache, pain or redness at the injection site, and drooping eyelids. Serious side effects are less common, but can include dry eyes, problems breathing, speaking or swallowing, and botulism. Daxxify is an injection given to you by a healthcare provider.

Uses

What is Daxxify used for?

Daxxify (daxibotulinumtoxinA-lanm) is commonly used for the following conditions.

To temporarily improve the look of moderate to severe frown lines between the eyebrows (glabellar lines)
A painful movement disorder causing your head to twist and turn or be pulled backward or forward due to muscle contractions in your neck (cervical dystonia)

Daxxify may also be used for other conditions as determined by your healthcare provider.

How does Daxxify work (mechanism of action)?

For cervical dystonia, Daxxify works to reduce spasms and pain by blocking certain nerve signals and reducing muscle activity at the site where it is injected.

For frown lines, Daxxify temporarily makes lines on your face look better by reducing the muscle activity between your eyebrows.

How is Daxxify supplied (dosage forms)?

Brands and other names

Daxxify

Daxxify is available as an injection that is given by a healthcare provider.

How should I store Daxxify?

Daxxify is usually given by a healthcare provider in a hospital or clinic. If you will store Daxxify at home, follow the instructions given by your healthcare provider.

Side Effects

What are the most common side effects of Daxxify?

The most common side effects of Daxxify are listed below. These side effects may vary depending on your age, the condition being treated, and where you receive your injection. Tell your healthcare provider if you have any of these side effects that bother you.

Headache
Drooping eyelids
Trouble moving face muscles
Pain or redness at the injection site
Muscle weakness
Infection in the nose or throat, sore throat, or common cold symptoms

There may be other side effects of Daxxify that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Daxxify?

While less common, the most serious side effects of Daxxify are described below, along with what to do if they happen.

Spread of Toxin Effects. The medicine in Daxxify may affect areas of your body away from the injection site. This may cause symptoms of a serious condition called botulism. Symptoms of botulism can start within hours, days, or weeks after your dose. Contact your healthcare provider right away if you have any of the following symptoms of botulism.

Loss of strength or muscle weakness all over the body
Double vision, blurred vision, and drooping eyelids
Losing your voice, changes in your voice, hoarseness, or trouble saying words clearly (dysarthria)
Loss of bladder control
Trouble breathing or swallowing

Severe Allergic Reactions. Daxxify may cause allergic reactions, which can be serious. Stop using Daxxify and get help right away if you have any of the following symptoms of a serious allergic reaction.

Breathing problems or wheezing
Racing heart
Fever or general ill feeling
Swollen lymph nodes
Swelling of the face, lips, mouth, tongue, or throat
Trouble swallowing or throat tightness
Itching, skin rash, or pale red bumps on the skin called hives
Nausea or vomiting
Dizziness, feeling lightheaded, or fainting
Stomach cramps
Joint pain

Breathing, Swallowing, or Speaking Problems. Daxxify may cause problems with breathing, swallowing or speaking. This can be serious or life-threatening. This is caused if the muscles you use to breathe and swallow become weak after the injection. It can happen hours, days, or weeks after your dose. Swallowing difficulties can last for several months. People who have trouble swallowing may need a feeding tube to get food and water. If swallowing issues are severe, food or liquids could get into your lungs. Get emergency medical help right away if you have trouble breathing, swallowing, or speaking.

Heart Effects. Daxxify may increase your risk of certain effects on the heart, such as causing an abnormal heart rhythm (arrhythmia) or a heart attack, which could lead to death. Get emergency help if you have chest pain or pressure, trouble breathing, or if you have a change in your heart rate or rhythm, such as a fast, slow, pounding, or skipping heartbeat.

Eye Dryness. When Daxxify is used to treat frown lines, it may cause dry eyes. Tell your healthcare provider if you have any of the following symptoms of eye dryness.

Changes in your vision
Eye pain or irritation
Eyes sensitive to light

Warnings & Precautions

Who should not use Daxxify?

Allergies to Ingredients. People who are allergic to any of the following should not use Daxxify.

DaxibotulinumtoxinA
Daxxify
Any other medicine known as a botulinum toxin product
Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Daxxify.

Skin Infection at the Injection Site. Daxxify should not be injected into skin that is infected. Tell your healthcare provider if you have any symptoms of skin infection, such as redness, pain, swelling, warm skin, or blisters.

What should I know about Daxxify before using it?

Do not use Daxxify unless it has been prescribed to you by a healthcare provider. Your healthcare provider will store and give you the medicine.

Daxxify may cause loss of strength, muscle weakness, vision problems, or drooping eyelids within hours, days, or weeks after an injection. If any of these happen to you, do not drive or do other activities that require alertness or coordination.

What should I tell my healthcare provider before using Daxxify?

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Daxxify is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your healthcare provider if you have any of the following.

Muscle or nerve disorders, such as amyotrophic lateral sclerosis (ALS) or Lou Gehrig’s disease, myasthenia gravis, or Lambert-Eaton syndrome
Breathing problems, such as asthma or emphysema
Swallowing problems
Plans to have surgery
Past surgery on your face
Bleeding problems
Heart problems, including heart disease
Weakness of your forehead muscles, such as trouble raising your eyebrows
Drooping eyelids
Changes in the way your face normally looks
Dry eyes after receiving any other botulinum product

Other Medicines and Supplements. Daxxify may interact with other medicines and supplements. Before using Daxxify, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Pregnancy. It is not known if or how Daxxify could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant.

Breastfeeding. It is not known if Daxxify passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should use Daxxify while breastfeeding.

How can I get more information about Daxxify?

For more information about Daxxify, you can visit the manufacturer’s website at www.daxxify.com (for frown lines) or www.daxxifycervicaldystonia.com (for cervical dystonia) or call them at 877-3REV-NOW (877-373-8669).

Interactions

Does Daxxify interact with foods or drinks?

There are no known interactions between Daxxify and foods or drinks.

It is unknown if drinking alcohol will affect Daxxify. If you have blurred vision from Daxxify, alcohol may worsen this effect.

Does Daxxify interact with other medicines (drug interactions)?

Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before using Daxxify.

A botulinum toxin product, such as rimabotulinumtoxinB (Myobloc), onabotulinumtoxinA (Botox, Botox Cosmetic), abobotulinumtoxinA (Dysport), prabotulinumtoxinA (Jeuveau), or incobotulinumtoxinA (Xeomin), which is a medicine commonly used to reduce wrinkles or spasms.
An aminoglycoside antibiotic, such as amikacin or gentamicin, which is given by injection to treat infections
An anticholinergic medicine, which includes antihistamines and medicines commonly used for overactive bladder, Parkinson’s disease, or stomach problems
A muscle relaxant, such as carisoprodol (Soma), cyclobenzaprine, or tizanidine (Zanaflex)
A sleep medicine, such as temazepam (Restoril), zolpidem (Ambien and others), or eszopiclone (Lunesta)
Aspirin, which is in many prescription and OTC products including those for pain, swelling, and fever
An antiplatelet medicine, such as clopidogrel (Plavix), ticagrelor (Brilinta), aspirin/dipyridamole, or cilostazol, which is a medicine used to prevent blood clots
A blood thinner, which is a medicine used to treat or prevent blood clots

This may not be a complete list of medicines that can interact with Daxxify. Always check with your healthcare provider.

Does interact with other drugs you are taking?

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