6 mins read

Overview: Vosevi is used to treat chronic hepatitis C virus (HCV) infection. It works by preventing the hepatitis C virus from making copies of itself. Common side effects include headache, tiredness, diarrhea, and nausea. Tell your health care provider about any medical conditions you have or have had in the past, including any other liver problems. Vosevi comes as a tablet that you take by mouth.

Uses

What is Vosevi used for?

Vosevi (sofosbuvir/velpatasvir/voxilaprevir) is commonly used to treat certain types of chronic hepatitis C virus (HCV) infection.

Vosevi may also be used for other conditions as determined by your health care provider.

How does Vosevi work (mechanism of action)?

Vosevi contains three medicines: sofosbuvir, velpatasvir, and voxilaprevir. They work together to prevent the hepatitis C virus from making copies of itself. Vosevi reduces the amount of virus in your body, which can help your body get rid of the virus.

How is Vosevi supplied (dosage forms)?

Brands and other names

  • Vosevi

Dosage forms and strengths

  • 400 mg/100 mg/100 mg oral tablets

How should I store Vosevi?

Vosevi should be stored in its original container, at a temperature below 86 F (30 C). 

Side Effects

What are the most common side effects of Vosevi?

The most common side effects of Vosevi are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Headache
  • Tiredness
  • Diarrhea
  • Nausea

There may be other side effects of Vosevi that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Vosevi?

While less common, the most serious side effects of Vosevi are described below, along with what to do if they happen.

Hepatitis B Virus Reactivation. If you have the hepatitis B virus in your body or have had hepatitis B in the past, Vosevi could make the virus active again. This could lead to serious liver problems or death. Keep all appointments for blood work before starting Vosevi and during treatment. Call your health care provider right away if you have any of the following symptoms of hepatitis.

  • Unusual tiredness
  • Your skin or the whites of your eyes turning yellowish in color (called jaundice)
  • Nausea, vomiting, or loss of appetite
  • Dark-colored pee
  • Fever or chills
  • Pain in your side
  • Stool (poop) that is clay-colored

Severe Allergic Reactions. Vosevi may cause allergic reactions, which can be serious. Stop taking Vosevi and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use Vosevi?

Allergies to Ingredients. People who are allergic to any of the following should not take Vosevi.

  • Sofosbuvir
  • Velpatasvir
  • Vosevi
  • Voxilaprevir
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Vosevi.

Drug Interactions. Vosevi should not be taken while you are using certain other medicines. Before taking Vosevi, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

What should I know about Vosevi before using it?

Do not take Vosevi unless it has been prescribed to you by a health care provider. Take it as prescribed.

Do not share Vosevi with other people, even if they have the same condition as you. It may harm them.

Take each dose of Vosevi with food.

Keep Vosevi out of the reach of children.

Taking certain antacids at the same time as Vosevi can make Vosevi not work as well. Talk with your health care provider about the best way to take antacids while taking Vosevi.

Make sure that you get refills before you run out of Vosevi. Do not stop taking it without talking to your health care provider first.

What should I tell my health care provider before using Vosevi?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Vosevi is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have any of the following.

  • Past or current hepatitis B infection
  • Liver problems other than hepatitis C infection
  • Kidney problems
  • HIV

Pregnancy. It is not known if or how Vosevi could affect pregnancy or harm a fetus. Tell your health care provider if you are pregnant or plan to become pregnant.

Breastfeeding. It is not known if Vosevi passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should take Vosevi while breastfeeding.

How can I get more information about Vosevi?

For more information about Vosevi, you can visit the drugmaker’s website at www.vosevi.com or call them at 800-445-3235.

Interactions

Does Vosevi interact with foods or drinks?

There are no known interactions between Vosevi and foods or drinks.

It is unknown if drinking alcohol will affect Vosevi. 

Does Vosevi interact with other medicines (drug interactions)?

Vosevi interacts with many other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss with your health care provider if you are using any of the following before taking Vosevi. 

  • Rifampin (Rifadin) or rifapentine (Priftin), which are commonly used to treat an infection called tuberculosis
  • Rifabutin (Mycobutin), which is a medicine used to prevent Mycobacterium avium complex infection
  • Amiodarone (Pacerone and others), which is a medicine used for an irregular heart rhythm
  • A beta-blocker, such as metoprolol (Lopressor, Toprol XL, and others), atenolol (Tenormin), or propranolol (Inderal LA, Innopran XL), which is a medicine that may be used for certain heart conditions or to lower blood pressure
  • An antacid containing aluminum, calcium, or magnesium
  • An H2 blocker, such as cimetidine (Tagamet), famotidine (Pepcid, Zantac), or nizatidine (Axid)
  • A proton pump inhibitor (PPI), such as esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), or rabeprazole (Aciphex)
  • A medicine for diabetes
  • Digoxin (Lanoxin), which is a medicine used to treat irregular heartbeat and some types of heart failure
  • Any medicine for seizures, such as carbamazepine, phenobarbital, or phenytoin
  • A medicine for HIV or AIDS, or any other medicine for hepatitis C
  • St. John’s wort, which is a supplement that may be used for depression
  • A statin, such as atorvastatin (Lipitor and others) or rosuvastatin (Crestor), which is a medicine to lower cholesterol
  • Cyclosporine (Gengraf, Neoral, Sandimmune, and others), which is a medicine that suppresses your immune system
  • A blood thinner, which is a medicine used to treat or prevent blood clots
  • Sulfasalazine (Azulfidine), which is a medicine used for certain inflammatory conditions, such as ulcerative colitis or rheumatoid arthritis
  • Methotrexate (Trexall and others), which is a medicine commonly used for rheumatoid arthritis and certain types of cancer
  • A medicine used to treat cancer

Many other medicines may alter the blood levels of Vosevi, and vice versa. Tell your health care provider about all medicines that you take or have recently taken.

This may not be a complete list of medicines that can interact with Vosevi. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Vosevi?

If you or someone else has used too much Vosevi, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Vosevi?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses. 

Missing doses of Vosevi can cause it to not work as well over time. So it is important not to miss or skip doses.